Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanotechnology may lead to new treatment of liver cancer

Abstract:
Nanotechnology may open a new door on the treatment of liver cancer, according to a team of Penn State College of Medicine researchers. They used molecular-sized bubbles filled with chemotherapy drugs to prevent cell growth and initiate cell death in test tubes and mice.

Nanotechnology may lead to new treatment of liver cancer

Hershey, PA | Posted on February 22nd, 2011

Researchers evaluated the use of molecular-sized bubbles filled with C6-ceramide, called cerasomes, as an anti-cancer agent. Ceramide is a lipid molecule naturally present in the cell's plasma membrane and controls cell functions, including cell aging, or senescence.

Hepatocellular carcinoma is the fifth most common cancer in the world and is highly aggressive. The chance of surviving five years is less than five percent, and treatment is typically chemotherapy and surgical management including transplantation.
"The beauty of ceramide is that it is non-toxic to normal cells, putting them to sleep, while selectively killing cancer cells," said Mark Kester, Ph.D., G. Thomas Passananti Professor of Pharmacology.

Cerasomes, developed at Penn State College of Medicine, can target cancer cells very specifically and accurately, rather than affecting a larger area that includes healthy cells. The problem with ceramide is that as a lipid, it cannot be delivered effectively as a drug. To solve this limitation, the researchers use nanotechnology, creating the tiny cerasome, to turn the insoluble lipid into a soluble treatment.

"Cerasomes were designed as a therapeutic alternative to common chemotherapeutics," said Kester. "These have been shown to be toxic to cancer cells and not to normal cells, and have already been shown to effectively treat cellular and animal models of breast cancer and melanoma. Cerasomes have also been shown to be essentially free of toxic side effects normally associated with anticancer agents."

In the test tube and animal models of liver cancer, cerasomes, but not a placebo, selectively induced cell death in the cancer cells.

In mice with liver cancer, cerasomes blocked tumor vascularisation, the forming of blood vessels needed for growth and nutrition. Studies show that lack of nutrition causes cells to create more ceramide and leads to cell death.

"It is plausible that preventing liver tumor vascularization with cerasome treatment could induce widespread apoptosis, a genetically programmed series of events that leads to cell death in tumors," Kester said. "The efficacy of our cerasomes in the treatment of diverse cancers lends significant therapeutic promise as it translates from bench to bedside."

The researchers published their work in the journal Gut. A Penn State Dean's Feasibility Grant, Pennsylvania tobacco settlement funds, and the National Institutes of Health supported this work.

In an earlier study published in the journal Blood, researchers observed that cerasome use led to complete remission in aggressive, large granular lymphocytic leukemia in rats. In addition, the protein survivin, which prevents cell death, is heavily produced in NK-leukemia cells, but not in normal cells. Cerasome decreased expression of survivin and may lead to a therapeutic approach for fatal leukemia.

Penn State Research Foundation has committed to licensing patent-pending ceramide-based nanotechnologies to Keystone Nano, Inc. That company is currently working to complete the preclinical package for cerasomes in human studies in patients with liver cancer. Kester is a co-founder and chief medical officer of Keystone Nano, Inc.

Other researchers are Hephzibah Rani S. Tagaram, M.D., Diego Avella, M.D, Eric. T. Kimchi, M.D., and Kevin F. Stavely O'Carroll, M.D., Department of Surgery; Nicole A. DiVittore, Brian M. Barth, Ph.D., and James M. Kaiser, Department of Pharmacology; Yixing Jiang, M.D., Ph.D., Department of Medicine; and Harriet C. Isom, Ph.D., Department of Microbiology and Immunology.

####

For more information, please click here

Contacts:
Scott Gilbert
717-531-1887

Copyright © Pennsylvania State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Study reveals how herpes virus tricks the immune system February 5th, 2016

Hepatitis virus-like particles as potential cancer treatment February 5th, 2016

Organic crystals allow creating flexible electronic devices: The researchers from the Faculty of Physics of the Moscow State University have grown organic crystals that allow creating flexible electronic devices February 5th, 2016

Researchers discover new phase of boron nitride and a new way to create pure c-BN February 5th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Hepatitis virus-like particles as potential cancer treatment February 5th, 2016

Researchers discover new phase of boron nitride and a new way to create pure c-BN February 5th, 2016

Scientists guide gold nanoparticles to form 'diamond' superlattices: DNA scaffolds cage and coax nanoparticles into position to form crystalline arrangements that mimic the atomic structure of diamond February 4th, 2016

Polar vortices observed in ferroelectric: New state of matter holds promise for ultracompact data storage and processing February 4th, 2016

Possible Futures

Hepatitis virus-like particles as potential cancer treatment February 5th, 2016

Scientists guide gold nanoparticles to form 'diamond' superlattices: DNA scaffolds cage and coax nanoparticles into position to form crystalline arrangements that mimic the atomic structure of diamond February 4th, 2016

Using mathematics to improve human health February 3rd, 2016

Scientists have put a high precision blood assay into a simple test strip: Researchers have developed a new biosensor test system based on magnetic nanoparticles February 3rd, 2016

Academic/Education

COD Grad Begins Postdoctoral Fellow at Harvard University: Marsela Jorgolli's Passion for Physics Has Led to a Decade of Academic Research That Continues at Harvard University as a Postdoctoral Fellow February 2nd, 2016

Heriot-Watt's Institute of Photonics & Quantum Sciences uses the Deben Microtest 2 kN tensile stage to characterise ceramics and engineering plastics January 21st, 2016

Multiple uses for the JPK NanoWizard AFM system in the Smart Interfaces in Environmental Nanotechnology Group at the University of Illinois at Urbana-Champaign January 20th, 2016

BioSolar Extends Research Agreement With UCSB for Next Phase of Its Super Battery Technology: Development Effort to Continue Under the Supervision of Nobel Laureate, Dr. Alan Heeger January 13th, 2016

Nanomedicine

Study reveals how herpes virus tricks the immune system February 5th, 2016

Hepatitis virus-like particles as potential cancer treatment February 5th, 2016

Researchers discover new phase of boron nitride and a new way to create pure c-BN February 5th, 2016

Nanoparticles Make Fertility Possible during Consumption of Anticancer Drugs February 4th, 2016

Announcements

Study reveals how herpes virus tricks the immune system February 5th, 2016

Hepatitis virus-like particles as potential cancer treatment February 5th, 2016

Organic crystals allow creating flexible electronic devices: The researchers from the Faculty of Physics of the Moscow State University have grown organic crystals that allow creating flexible electronic devices February 5th, 2016

Researchers discover new phase of boron nitride and a new way to create pure c-BN February 5th, 2016

Patents/IP/Tech Transfer/Licensing

Joint Efforts by Iranian, Malaysian Scientists Produce Antibacterial Coatings for Isolated Areas February 4th, 2016

Silicon-based metamaterials could bring photonic circuits February 1st, 2016

Therapeutic Solutions International Licenses Dexosome Clinical Stage Cancer Immunotherapy Product From Gustave Roussy European Cancer Centre: FDA Cleared Immuno-Oncology Technology to Resume Clinical Development for Solid Tumor Patients January 27th, 2016

Light-activated nanoparticles prove effective against antibiotic-resistant 'superbugs' January 19th, 2016

Nanobiotechnology

Hepatitis virus-like particles as potential cancer treatment February 5th, 2016

Novel nanoparticle made of common mineral may help keep tumor growth at bay February 4th, 2016

Nanoparticles Make Fertility Possible during Consumption of Anticancer Drugs February 4th, 2016

Using mathematics to improve human health February 3rd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic