Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Plankton inspires creation of stealth armour for slow release microscopic drug vesicles

Abstract:
The ability of some forms of plankton and bacteria to build an extra natural layer of nanoparticle-like armour has inspired chemists at the University of Warwick to devise a startlingly simple way to give drug bearing polymer vesicles (microscopic polymer based sacs of liquid) their own armoured protection.

Plankton inspires creation of stealth armour for slow release microscopic drug vesicles

UK | Posted on February 3rd, 2011

The Warwick researchers have been able to decorate these hollow structures with a variety of nanoparticles opening a new strategy in the design of vehicles for drug release, for example by giving the vesicle "stealth" capabilities which can avoid the body's defences while releasing the drug.

Advances in polymerisation have led to a surge in the creation of vesicles made from polymer molecules. Such vesicles have interesting chemical and physical properties which makes these hollow structures potential drug delivery vehicles.

The University of Warwick team were convinced that even more strength, and interesting tailored properties, could be given to the vesicles if they could add an additional layer of colloidal armour made from a variety of nanoparticles.

Lead researcher on the University of Warwick team Associate Professor Stefan Bon said:

"We took our inspiration from nature, in how it adds protection and mechanical strength in certain classes of cells and organisms. In addition to the mechanical strength provided by the cytoskeleton of the cell, plants, fungi, and certain bacteria have an additional cell wall as outermost boundary. Organisms that particularly attracted our interest were those with a cell wall composed of an armour of colloidal objects - for instance bacteria coated with S-layer proteins, or phytoplankton, such as the coccolithophorids, which have their own CaCO3-based nano-patterned colloidal armour"

The Warwick researchers hit on a surprisingly simple and highly effective method of adding a range of different types of additional armour to the polymer based vesicles. One of those armour types was a highly regular packed layer of microscopic polystyrene balls. This configuration meant the researchers could design a vesicle which had an additional and precise permeable reinforced barrier for drug release, as a result of the crystalline-like ordered structure of the polystyrene balls.

The researchers also succeeded in using the same technique to add a gelatine-like polymer to provide a "stealth" armour to shield vesicles from unwanted attention from the body's immune system while it slowly released its drug treatment. This particular coating (a poly((ethyl acrylate)-co-(methacrylic acid)) hydrogel) absorbs so much surrounding water into its outer structure that it may be able to fool the body's defence mechanism into believing it is in fact just water.

The Warwick researchers had the idea of simply giving their chosen colloidal particles, or latex, based armour the opposite charge to that of the polymer vesicles, to bind them together. This turned out to be even more effective and easy to manipulate and tailor than they even they had hoped for. However the researchers needed a new way of actually observing the vesicles to see if their plan had worked. Previous observational methods required researchers to dry out the vesicles before examining then under an electron microscope - but this seriously deformed the vesicles and thus provide little useful data. However the University of Warwick had recently acquired a cryo electron microscope thanks to funding from the Science City programme. This allowed the research team to quickly freeze the vesicles to -150oc preserving the vesicles shape before observation by the electron microscope. This revealed that the researchers' simple charge based method had worked exactly as planned.

The research has just been published in a paper entitled Polymer Vesicles with a Colloidal Armor of Nanoparticles by Rong Chen, Daniel J. G. Pearce, Sara Fortuna, David L. Cheung, and Stefan A. F. Bon* Department of Chemistry, University of Warwick in the current Journal of the American Chemical Society dx.doi.org/10.1021/ja110359f

####

For more information, please click here

Contacts:
Dr.ir. Stefan A. F. Bon
Department of Chemistry
University of Warwick, CV4 7AL, UK
Tel: (+44) (0)24 76 574009


Peter Dunn
Head of Communications,
Communications Office,
University of Warwick, Coventry, CV4 8UW, United Kingdom
Tel: (+44) (0)24 7652 3708
Mobile: (+44) (0)7767 655860

Copyright © University of Warwick

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

East China University of Science and Technology Purchases Nanonex Advanced Nanoimprint Tool NX-B200 July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

FLAG-ERA and TNT2014 join efforts: Graphene Networking at its higher level in Barcelona: Encourage the participation in a joint transnational call July 30th, 2014

Possible Futures

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

Academic/Education

University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Haydale Announces Collaboration Agreement with Swansea University’s Welsh Centre for Printing and Coatings (WCPC) July 12th, 2014

STFC takes delivery of the 100th Hitachi Tabletop SEM in the UK July 3rd, 2014

Innovation Management and the Emergence of the Nanobiotechnology Industry July 1st, 2014

Nanomedicine

New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Announcements

University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Analytical solutions from Malvern Instruments support University of Wisconsin-Milwaukee researchers in understanding environmental effects of nanomaterials July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

Nanobiotechnology

Harris & Harris Group Invests in Unique NYC Biotech Accelerator July 29th, 2014

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE