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|Scatter diagram showing high performance using NanoSight NTA for polydisperse samples|
NanoSight, world-leading manufacturers of unique nanoparticle characterization technology announce the release of their latest NS200 nanoparticle characterization system. It will be shown and demonstrated for the first time at the renowned US Pittsburgh Conference and Exposition being held in 2011 in Atlanta, Georgia from March 14 until 17th, booth #519.
Based on the well-adopted LM20 model applying their unique particle-by-particle visualization and counting method, Nanoparticle Tracking Analysis or NTA, NanoSight has taken advantage of developments in hardware to produce an easier-to-use instrument with a high sensitivity camera built into the housing of the system.
With optimized locators for making it very easy to position the measurement cell and with an electronic readout of the cell test temperature, NanoSight have set out producing a design of instrument to meet the growing need for systems with a recognised SOP, standard operating procedure.
The system has an optional blue laser to improve imaging capability, and fluorescence filters can be added when working with suitably labelled particles. The EMCCD (electron multiplying CCD) camera is designed with maximal speed and sensitivity in mind. With 37 full frames/second collected directly through a universal USB2.0 interface, the EMCCD has greatly enhanced performance over the standard CCD previously supplied. Furthermore, the laser in the NS200 is triggered to reduce thermal issues with respect to the sample, restricting photobleaching during fluorescence imaging.
The end result is a ruggedly constructed instrument which requires minimal operator skills. Training is very rapid and operators can produce consistent results within a very short time from introduction.
With applications transcending the life sciences through the materials sciences, NanoSight have installed more than 300 systems worldwide as NTA becomes increasingly accepted as the technique to quantitatively study nanoparticles. To learn more about nanoparticle characterization using Nanoparticle Tracking Analysis, NTA, please visit the company website (www.nanosight.com) and register for the latest issue of NanoTrail, the company's electronic newsletter.
NanoSight delivers the world’s most versatile and proven multi-parameter nanoparticle analysis in a single instrument.
NanoSight visualizes, measures and characterizes virtually all nanoparticles. Particle size, concentration, Zeta potential and aggregation can all be analyzed while a fluorescence mode provides differentiation of labelled particles. NanoSight presents real time monitoring of the subtle changes in the characteristics of particle populations with all of these analyses uniquely confirmed by visual validation.
NanoSight’s “Nanoparticle Tracking Analysis” (NTA) detects and visualizes populations of nanoparticles in liquids down to 10nm, dependent on material, and measures the size of each particle from direct observations of diffusion. This particle-by-particle methodology goes beyond traditional light scattering and other ensemble techniques in providing high-resolution particle size distributions. Additionally, NanoSight measures concentration and validates data with information-rich video files of the particles moving under Brownian motion.
NanoSight’s comprehensive characterization matches the demands of complex biological systems, hence its wide application in development of drug delivery systems, of viral vaccines, in nanotoxicology and in biodiagnostics. This real-time data gives insight into the kinetics of protein aggregation and other time-dependent phenomena in a qualitative and quantitative manner.
NanoSight has a growing role in biodiagnostics, being proven in detection and speciation of nanovesicles (exosomes) and microvesicles. As functionalized nanoparticles increasingly fulfill their potential in biodiagnostics, NanoSight is ever more the analytical platform of choice.
NanoSight demonstrates worldwide success through rapid adoption of NTA, having installed more than 300 systems worldwide with users including BASF, GlaxoSmithKline, Merck, Novartis, Pfizer, Proctor and Gamble, Roche and Unilever together with the most eminent universities and research institutes. In addition to this user base more than 150 third party papers citing NanoSight results consolidate NanoSight’s leadership position in nanoparticle characterization. For more information, visit the NanoSight website (www.nanosight.com).
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