Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Silicon Nanocrystals Map Location of Spreading Tumors

Quantum dots (QDs) have size-dependent optical properties that make them uniquely advantageous for in vivo targeted fluorescence imaging, traceable delivery, and therapy. The use of group II−VI (e.g., CdSe) QDs for these applications is advancing rapidly. Credit ACS Nano
Quantum dots (QDs) have size-dependent optical properties that make them uniquely advantageous for in vivo targeted fluorescence imaging, traceable delivery, and therapy. The use of group II−VI (e.g., CdSe) QDs for these applications is advancing rapidly. Credit ACS Nano

Abstract:
Nano-sized fluorescent particles known as quantum dots have shown promise as powerful imaging agents capable of detecting a wide range of diseases, but these nanoparticles are usually made with toxic metals such as cadmium. Now, researchers at the University of Buffalo have developed a novel synthetic method that enables them to design and create biocompatible fluorescent nanocrystals made of non-toxic silicon. More importantly, the investigators have used these silicon nanocrystals to image tumors and spot spreading cancer in lymph nodes.

Silicon Nanocrystals Map Location of Spreading Tumors

Bethesda, MD | Posted on January 19th, 2011

Reporting its work in the journal ACS Nano, a team of investigators led by Paras Prasad describes the two-step process they use to prepare polymer-coated, fluorescent silicon nanoparticles to which they can attach a variety of tumor-targeting molecules, including a small peptide known as RGD that binds to the new blood vessels that surround tumors. This synthetic process allowed the researchers to prepare silicon nanocrystals of well-defined sizes, each with its own characteristic fluorescent emission peak. The polymer coating prevents the nanocrystals from being eliminated rapidly inside the body, a fate that normally awaits unprotected silicon particles in the body.

After demonstrating that RGD-derivatized nanocrystals were non-toxic in both cultured cell and whole animal studies, the investigators showed that they could use the nanocrystals to image pancreatic tumors growing in mice, and to detect tumors in tissue specimens removed for biopsy. The investigators also showed that they could use non-targeted silicon nanocrystals to map sentinel lymph nodes in mice, the lymph nodes where metastatic cells first accumulate when spreading through the body.

This work, which is detailed in a paper titled, "In vivo Targeted Cancer Imaging, Sentinel Lymph Node Mapping and Multi-Channel Imaging with Biocompatible Silicon Nanocrystals," was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. At the time of this work, Dr. Prasad was the principal investigator of one of 12 Cancer Nanotechnology Platform Partnerships funded during the NCI' Alliance's first five-year phase. An abstract of this paper is available at the journal's website.

View abstract pubs.acs.org/doi/abs/10.1021/nn1018945

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Scientists Produce Transparent Nanocomposite Coatings with Longer Lifetime July 24th, 2014

Hysitron is Awarded TWO R&D 100 Awards for Highly Innovative Technology Developments in the Areas of Extreme Environments and Biological Mechanical Property Testing July 23rd, 2014

NNCO Announces an Interactive Webinar: Progress Review on the Coordinated Implementation of the National Nanotechnology Initiative 2011 Environmental, Health, and Safety Research Strategy July 23rd, 2014

A Crystal Wedding in the Nanocosmos July 23rd, 2014

Possible Futures

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

Academic/Education

Haydale Announces Collaboration Agreement with Swansea University’s Welsh Centre for Printing and Coatings (WCPC) July 12th, 2014

STFC takes delivery of the 100th Hitachi Tabletop SEM in the UK July 3rd, 2014

Innovation Management and the Emergence of the Nanobiotechnology Industry July 1st, 2014

Albany NanoCollege Faculty Member Selected as Editor-in-Chief of the Prestigious Journal of Electronic Materials July 1st, 2014

Nanomedicine

Researchers create vaccine for dust-mite allergies Main Page Content: Vaccine reduced lung inflammation to allergens in lab and animal tests July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

SentiMag® Now Available in Australia and New Zealand July 21st, 2014

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs July 21st, 2014

Announcements

Iranian Scientists Produce Transparent Nanocomposite Coatings with Longer Lifetime July 24th, 2014

UCF Nanotech Spinout Developing Revolutionary Battery Technology: Power the Next Generation of Electronics with Carbon July 23rd, 2014

Deadline Announced for Registration in 7th Int'l Nanotechnology Festival in Iran July 23rd, 2014

A Crystal Wedding in the Nanocosmos July 23rd, 2014

Quantum Dots/Rods

Researchers create quantum dots with single-atom precision June 30th, 2014

New Los Alamos Approach May Be Key to Quantum Dot Solar Cells With Real Gains in Efficiency: Nanoengineering Boosts Carrier Multiplication in Quantum Dots June 19th, 2014

MIPT-based researcher predicts new state of matter June 17th, 2014

Technology using microwave heating may impact electronics manufacture June 10th, 2014

Nanobiotechnology

Production of Non-Virus Nanocarriers with Highest Amount of Gene Delivery July 17th, 2014

Physicists Use Computer Models to Reveal Quantum Effects in Biological Oxygen Transport: The team solved a long-standing question by explaining why oxygen – and not deadly carbon monoxide – preferably binds to the proteins that transport it around the body. July 17th, 2014

Tiny DNA pyramids enter bacteria easily -- and deliver a deadly payload July 9th, 2014

Artificial cilia: Scientists from Kiel University develop nano-structured transportation system July 4th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE