Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Silicon Nanocrystals Map Location of Spreading Tumors

Quantum dots (QDs) have size-dependent optical properties that make them uniquely advantageous for in vivo targeted fluorescence imaging, traceable delivery, and therapy. The use of group II−VI (e.g., CdSe) QDs for these applications is advancing rapidly. Credit ACS Nano
Quantum dots (QDs) have size-dependent optical properties that make them uniquely advantageous for in vivo targeted fluorescence imaging, traceable delivery, and therapy. The use of group II−VI (e.g., CdSe) QDs for these applications is advancing rapidly. Credit ACS Nano

Abstract:
Nano-sized fluorescent particles known as quantum dots have shown promise as powerful imaging agents capable of detecting a wide range of diseases, but these nanoparticles are usually made with toxic metals such as cadmium. Now, researchers at the University of Buffalo have developed a novel synthetic method that enables them to design and create biocompatible fluorescent nanocrystals made of non-toxic silicon. More importantly, the investigators have used these silicon nanocrystals to image tumors and spot spreading cancer in lymph nodes.

Silicon Nanocrystals Map Location of Spreading Tumors

Bethesda, MD | Posted on January 19th, 2011

Reporting its work in the journal ACS Nano, a team of investigators led by Paras Prasad describes the two-step process they use to prepare polymer-coated, fluorescent silicon nanoparticles to which they can attach a variety of tumor-targeting molecules, including a small peptide known as RGD that binds to the new blood vessels that surround tumors. This synthetic process allowed the researchers to prepare silicon nanocrystals of well-defined sizes, each with its own characteristic fluorescent emission peak. The polymer coating prevents the nanocrystals from being eliminated rapidly inside the body, a fate that normally awaits unprotected silicon particles in the body.

After demonstrating that RGD-derivatized nanocrystals were non-toxic in both cultured cell and whole animal studies, the investigators showed that they could use the nanocrystals to image pancreatic tumors growing in mice, and to detect tumors in tissue specimens removed for biopsy. The investigators also showed that they could use non-targeted silicon nanocrystals to map sentinel lymph nodes in mice, the lymph nodes where metastatic cells first accumulate when spreading through the body.

This work, which is detailed in a paper titled, "In vivo Targeted Cancer Imaging, Sentinel Lymph Node Mapping and Multi-Channel Imaging with Biocompatible Silicon Nanocrystals," was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. At the time of this work, Dr. Prasad was the principal investigator of one of 12 Cancer Nanotechnology Platform Partnerships funded during the NCI' Alliance's first five-year phase. An abstract of this paper is available at the journal's website.

View abstract pubs.acs.org/doi/abs/10.1021/nn1018945

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The next generation of carbon monoxide nanosensors May 26th, 2016

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

Gigantic ultrafast spin currents: Scientists from TU Wien (Vienna) are proposing a new method for creating extremely strong spin currents. They are essential for spintronics, a technology that could replace today's electronics May 25th, 2016

Diamonds closer to becoming ideal semiconductors: Researchers find new method for doping single crystals of diamond May 25th, 2016

Possible Futures

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

Gigantic ultrafast spin currents: Scientists from TU Wien (Vienna) are proposing a new method for creating extremely strong spin currents. They are essential for spintronics, a technology that could replace today's electronics May 25th, 2016

Diamonds closer to becoming ideal semiconductors: Researchers find new method for doping single crystals of diamond May 25th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Academic/Education

Graphene: Progress, not quantum leaps May 23rd, 2016

Smithsonian Science Education Center and National Space Society Team Up for Next-Generation Space Education Program "Enterprise In Space" May 11th, 2016

The University of Colorado Boulder, USA, combines Raman spectroscopy and nanoindentation for improved materials characterisation May 9th, 2016

Albertan Science Lab Opens in India May 7th, 2016

Nanomedicine

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Programmable materials find strength in molecular repetition May 23rd, 2016

Tiny packages may pack powerful treatment for brain tumors: Nanocarrier provides efficient delivery of chemotherapeutic drug May 23rd, 2016

Announcements

The next generation of carbon monoxide nanosensors May 26th, 2016

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

Gigantic ultrafast spin currents: Scientists from TU Wien (Vienna) are proposing a new method for creating extremely strong spin currents. They are essential for spintronics, a technology that could replace today's electronics May 25th, 2016

Diamonds closer to becoming ideal semiconductors: Researchers find new method for doping single crystals of diamond May 25th, 2016

Quantum Dots/Rods

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

ORNL demonstrates large-scale technique to produce quantum dots May 21st, 2016

First single-enzyme method to produce quantum dots revealed: Biological manufacturing process, pioneered by three Lehigh University engineers, produces equivalent quantum dots to those made chemically--but in a much greener, cheaper way May 9th, 2016

Superfast light source made from artificial atom April 28th, 2016

Nanobiotechnology

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Programmable materials find strength in molecular repetition May 23rd, 2016

Tiny packages may pack powerful treatment for brain tumors: Nanocarrier provides efficient delivery of chemotherapeutic drug May 23rd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic