Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Silicon Nanocrystals Map Location of Spreading Tumors

Quantum dots (QDs) have size-dependent optical properties that make them uniquely advantageous for in vivo targeted fluorescence imaging, traceable delivery, and therapy. The use of group II−VI (e.g., CdSe) QDs for these applications is advancing rapidly. Credit ACS Nano
Quantum dots (QDs) have size-dependent optical properties that make them uniquely advantageous for in vivo targeted fluorescence imaging, traceable delivery, and therapy. The use of group II−VI (e.g., CdSe) QDs for these applications is advancing rapidly. Credit ACS Nano

Abstract:
Nano-sized fluorescent particles known as quantum dots have shown promise as powerful imaging agents capable of detecting a wide range of diseases, but these nanoparticles are usually made with toxic metals such as cadmium. Now, researchers at the University of Buffalo have developed a novel synthetic method that enables them to design and create biocompatible fluorescent nanocrystals made of non-toxic silicon. More importantly, the investigators have used these silicon nanocrystals to image tumors and spot spreading cancer in lymph nodes.

Silicon Nanocrystals Map Location of Spreading Tumors

Bethesda, MD | Posted on January 19th, 2011

Reporting its work in the journal ACS Nano, a team of investigators led by Paras Prasad describes the two-step process they use to prepare polymer-coated, fluorescent silicon nanoparticles to which they can attach a variety of tumor-targeting molecules, including a small peptide known as RGD that binds to the new blood vessels that surround tumors. This synthetic process allowed the researchers to prepare silicon nanocrystals of well-defined sizes, each with its own characteristic fluorescent emission peak. The polymer coating prevents the nanocrystals from being eliminated rapidly inside the body, a fate that normally awaits unprotected silicon particles in the body.

After demonstrating that RGD-derivatized nanocrystals were non-toxic in both cultured cell and whole animal studies, the investigators showed that they could use the nanocrystals to image pancreatic tumors growing in mice, and to detect tumors in tissue specimens removed for biopsy. The investigators also showed that they could use non-targeted silicon nanocrystals to map sentinel lymph nodes in mice, the lymph nodes where metastatic cells first accumulate when spreading through the body.

This work, which is detailed in a paper titled, "In vivo Targeted Cancer Imaging, Sentinel Lymph Node Mapping and Multi-Channel Imaging with Biocompatible Silicon Nanocrystals," was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. At the time of this work, Dr. Prasad was the principal investigator of one of 12 Cancer Nanotechnology Platform Partnerships funded during the NCI' Alliance's first five-year phase. An abstract of this paper is available at the journal's website.

View abstract pubs.acs.org/doi/abs/10.1021/nn1018945

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

French Institutes IRT Nanoelec and CMP Team up to Offer World’s First Service for Post-process 3D Technologies on Multi-Project-Wafer March 5th, 2015

The George Washington University Opens Science and Engineering Hall, Largest Building of Its Kind in D.C.: Building Represents Significant Investment in Research Programs and Facilities; Commitment to Solve Global Problems, Improve Lives of Millions March 5th, 2015

Anousheh Ansari Wins the National Space Society's Space Pioneer Award for "Service to the Space Community" March 5th, 2015

Enhanced Graphene Components for Next Generation Racing Yacht March 5th, 2015

Possible Futures

European roadmap for graphene science and technology published February 25th, 2015

Quantum research past, present and future for discussion at AAAS February 16th, 2015

World’s first compact rotary 3D printer-cum-scanner unveiled at AAAS by NTU Singapore start-up: With production funded by crowdsourcing, the first unit will be delivered to the United States in March February 16th, 2015

Nanotechnology Electric Vehicle (EV) Market Analysis Report 2015: According to Radiant Insights, Inc February 13th, 2015

Academic/Education

Get ready for NanoDays! March 5th, 2015

NanoTecNexus Launches New App for Learning About Nanotechnology—STEM Education Project Spearheaded by Interns February 26th, 2015

SUNY Poly CNSE Researchers and Corporate Partners to Present Forty Papers at Globally Recognized Lithography Conference: SUNY Poly CNSE Research Group Awarded Both ‘Best Research Paper’ and ‘Best Research Poster’ at SPIE Advanced Lithography 2015 forum February 25th, 2015

KIT Increases Commitment in Asia: DAAD Funds Two New Projects: Strategic Partnerships with Chinese Universities and Communi-cation Technologies Network February 22nd, 2015

Nanomedicine

Patent for the Novel Cancer Therapies – Ceramide Nanoliposomes March 4th, 2015

Arrowhead to Present at 2015 Barclays Global Healthcare Conference March 4th, 2015

Democratizing synthetic biology: New method makes research cheaper, faster, and more accessible March 3rd, 2015

Pens filled with high-tech inks for do-it-yourself sensors March 3rd, 2015

Announcements

The George Washington University Opens Science and Engineering Hall, Largest Building of Its Kind in D.C.: Building Represents Significant Investment in Research Programs and Facilities; Commitment to Solve Global Problems, Improve Lives of Millions March 5th, 2015

Anousheh Ansari Wins the National Space Society's Space Pioneer Award for "Service to the Space Community" March 5th, 2015

Enhanced Graphene Components for Next Generation Racing Yacht March 5th, 2015

Get ready for NanoDays! March 5th, 2015

Quantum Dots/Rods

Optical nanoantennas set the stage for a NEMS lab-on-a-chip revolution February 24th, 2015

QD Vision Named Edison Award Finalist for Innovative Color IQ™ Quantum Dot Technology February 23rd, 2015

Ocean Optics Names Winner of 2015 Young Investigator Award: Cash prize and grant awarded during SPIE BiOS/Photonics West 2015 conference February 21st, 2015

Rediscovering spontaneous light emission: Berkeley researchers develop optical antenna for LEDs February 3rd, 2015

Nanobiotechnology

Experiment and theory unite at last in debate over microbial nanowires: New model and experiments settle debate over metallic-like conductivity of microbial nanowires in bacterium March 4th, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Bacteria network for food: Bacteria connect to each other and exchange nutrients February 23rd, 2015

Building tailor-made DNA nanotubes step by step: New, block-by-block assembly method could pave way for applications in opto-electronics, drug delivery February 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE