Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > A Nanoscale Rope, and Another Step Toward Complex Nanomaterials That Assemble Themselves

Berkeley Lab scientists have developed a nanoscale rope that braids itself, as seen in this atomic force microscopy image of the structure at a resolution of one-millionth of a meter.
Berkeley Lab scientists have developed a nanoscale rope that braids itself, as seen in this atomic force microscopy image of the structure at a resolution of one-millionth of a meter.

Abstract:
Scientists at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have coaxed polymers to braid themselves into wispy nanoscale ropes that approach the structural complexity of biological materials.

A Nanoscale Rope, and Another Step Toward Complex Nanomaterials That Assemble Themselves

Berkeley, CA | Posted on January 19th, 2011

Their work is the latest development in the push to develop self-assembling nanoscale materials that mimic the intricacy and functionality of nature's handiwork, but which are rugged enough to withstand harsh conditions such as heat and dryness.

Although still early in the development stage, their research could lead to new applications that combine the best of both worlds. Perhaps they'll be used as scaffolds to guide the construction of nanoscale wires and other structures. Or perhaps they'll be used to develop drug-delivery vehicles that target disease at the molecular scale, or to develop molecular sensors and sieve-like devices that separate molecules from one another.

Specifically, the scientists created the conditions for synthetic polymers called polypeptoids to assemble themselves into ever more complicated structures: first into sheets, then into stacks of sheets, which in turn roll up into double helices that resemble a rope measuring only 600 nanometers in diameter (a nanometer is a billionth of a meter).

"This hierarchichal self assembly is the hallmark of biological materials such as collagen, but designing synthetic structures that do this has been a major challenge," says Ron Zuckermann, who is the Facility Director of the Biological Nanostructures Facility in Berkeley Lab's Molecular Foundry.

In addition, unlike normal polymers, the scientists can control the atom-by-atom makeup of the ropy structures. They can also engineer helices of specific lengths and sequences. This "tunability" opens the door for the development of synthetic structures that mimic biological materials' ability to carry out incredible feats of precision, such as homing in on specific molecules.

"Nature uses exact length and sequence to develop highly functional structures. An antibody can recognize one form of a protein over another, and we're trying to mimic this," adds Zuckermann.

Zuckermann and colleagues conducted the research at The Molecular Foundry, which is one of the five DOE Nanoscale Science Research Centers premier national user facilities for interdisciplinary research at the nanoscale. Joining him were fellow Berkeley Lab scientists Hannah Murnen, Adrianne Rosales, Jonathan Jaworski, and Rachel Segalman. Their research was published in a recent issue of the Journal of the American Chemical Society.

The scientists worked with chains of bioinspired polymers called a peptoids. Peptoids are structures that mimic peptides, which nature uses to form proteins, the workhorses of biology. Instead of using peptides to build proteins, however, the scientists are striving to use peptoids to build synthetic structures that behave like proteins.

The team started with a block copolymer, which is a polymer composed of two or more different monomers.

"Simple block copolymers self assemble into nanoscale structures, but we wanted to see how the detailed sequence and functionality of bioinspired units could be used to make more complicated structures," says Rachel Segalman, a faculty scientist at Berkeley Lab and professor of Chemical and Biomolecular Engineering at University of California, Berkeley.

With this in mind, the peptoid pieces were robotically synthesized, processed, and then added to a solution that fosters self assembly.

The result was a variety of self-made shapes and structures, with the braided helices being the most intriguing. The hierarchical structure of the helix, and its ability to be manipulated atom-by-atom, means that it could be used as a template for mineralizing complex structures on a nanometer scale.

"The idea is to assemble structurally complex structures at the nanometer scale with minimal input," says Hannah Murnen. She adds that the scientists next hope is to capitalize on the fact that they have minute control over the structure's sequence, and explore how very small chemical changes alter the helical structure.

Says Zuckermann, "These braided helices are one of the first forays into making atomically defined block copolymers. The idea is to take something we normally think of as plastic, and enable it to adopt structures that are more complex and capable of higher function, such as molecular recognition, which is what proteins do really well."

X-ray diffraction experiments used to characterize the structures were conducted at beamlines 8.3.1 and 7.3.3 of Berkeley Lab's Advanced Light Source, a national user facility that generates intense x-rays to probe the fundamental properties of substances. This work was supported in part by the Office of Naval Research.

Lawrence Berkeley National Laboratory is a U.S. Department of Energy (DOE) national laboratory managed by the University of California for the DOE Office of Science. Berkeley Lab provides solutions to the world's most urgent scientific challenges including sustainable energy, climate change, human health, and a better understanding of matter and force in the universe. It is a world leader in improving our lives through team science, advanced computing, and innovative technology. Visit our website.
Additional information:

* The paper, "Hierarchical Self-Assembly of a Biomimetic Diblock Copolypeptoid into Homochiral Superhelices," was published online in the Oct. 22 in the Journal of the American Chemical Society.

####

For more information, please click here

Contacts:
Dan Krotz
(510) 486-4019

Copyright © Lawrence Berkeley National Laboratory

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360ís Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

Possible Futures

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

Academic/Education

Graphene: Progress, not quantum leaps May 23rd, 2016

Smithsonian Science Education Center and National Space Society Team Up for Next-Generation Space Education Program "Enterprise In Space" May 11th, 2016

The University of Colorado Boulder, USA, combines Raman spectroscopy and nanoindentation for improved materials characterisation May 9th, 2016

Albertan Science Lab Opens in India May 7th, 2016

Self Assembly

Searching for a nanotech self-organizing principle May 1st, 2016

Researchers create artificial protein to control assembly of buckyballs April 27th, 2016

Brookhaven's Oleg Gang Named a Battelle 'Inventor of the Year': Recognized for work using DNA to guide and regulate the self-assembly of nanoparticles into clusters and arrays with controllable properties April 25th, 2016

Researchers develop new semiconducting polymer for forthcoming flexible electronics April 21st, 2016

Nanomedicine

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Programmable materials find strength in molecular repetition May 23rd, 2016

Tiny packages may pack powerful treatment for brain tumors: Nanocarrier provides efficient delivery of chemotherapeutic drug May 23rd, 2016

Materials/Metamaterials

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

Diamonds closer to becoming ideal semiconductors: Researchers find new method for doping single crystals of diamond May 25th, 2016

Announcements

PETA science group publishes a review on pulmonary effects of nanomaterials: Archives of Toxicology publishes a review of scientific studies on fibrotic potential of nanomaterials May 26th, 2016

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Nanobiotechnology

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Programmable materials find strength in molecular repetition May 23rd, 2016

Tiny packages may pack powerful treatment for brain tumors: Nanocarrier provides efficient delivery of chemotherapeutic drug May 23rd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic