Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Clarkson University Professor Synthesizes Brightest Fluorescent Nanoparticles Applications in material science, medicine and biology

Transmission electron microscopy (TEM) image of an ultrabright fluorescent mesoporous silica nanoparticle (image colored artificially to match the actual color of the dye in the particles).
Transmission electron microscopy (TEM) image of an ultrabright fluorescent mesoporous silica nanoparticle (image colored artificially to match the actual color of the dye in the particles).

Abstract:
Clarkson University Physics Professor Igor Sokolov and his team have discovered a method of making the brightest ever synthesized fluorescent silica nanoparticles.

Clarkson University Professor Synthesizes Brightest Fluorescent Nanoparticles Applications in material science, medicine and biology

Potsdam, NY | Posted on January 17th, 2011

The scientists reported on the first successful approach to synthesizing ultrabright fluorescent mesoporous silica nanoparticles this fall in the leading interdisciplinary scientific journal Small.

You can see the full article at onlinelibrary.wiley.com/doi/10.1002/smll.201001337/abstract

These nanoparticles have potential applications in medicine, biology, material science, and environmental protection, among many other uses.

Fluorescent materials are already used in many of these applications. However, having much brighter labeling particles will allow much finer detection of environmental pollutants, signals in biosensors and even the detection of explosives.

In fluorescence, an initial ignition light energizes molecules, and then the molecules reemit the light with a different color. This phenomenon can be used in many different applications because it is easily detectable, using optical filters to remove the ignition light, leaving only the particles' light visible.

"The particles should have a significant impact in the biomedical area," says Sokolov. "For example, you can create particles of different colors, which can be made to stick to particular biological molecules inside cells. Then you can see and trace those molecules easily with existing fluorescent microscopes. This fluorescent labeling helps to identify diseased cells and may show what is causing the disease. The particles are much more stable against photo-beaching than typical fluorescent dye. This means that one can trace the particles for a very long time."

Sokolov's process physically entraps a large number of organic fluorescent molecules inside nanoporous silica particles, which can be 20 to 50 nanometers in diameter, while preventing the molecules from leaking.

As an example of their brightness, the fluorescence of 40-nanometer particles is 34 times brighter than the brightest water-dispersible (25-30 nanometer) quantum dots and seem to be the brightest nanoparticles created so far.

In 2007, Sokolov and his team discovered a method of making the brightest ever synthesized fluorescent silica micro (non-nano) particles. Various attempts to decrease the size of the particles down to the nanoscale led to the particles that were bright but not ultrabright. The problem was in the dye leakage. It took the group several years to finally synthesize the ultrabright nanoparticles.

Sokolov and postdoctoral fellow Eun-Bum Cho (now an assistant professor at Seoul National University of Science and Technology) and Ph.D. student Dmytro Volkov developed the process, which gives the desired nanoparticles. The group, which now includes postdoctoral fellow Shajesh Palantavida, is currently looking at the development of the particles suitable for biomedical labeling.

The research was partially supported by the National Science Foundation and the U.S. Army Research Laboratory's Army Research Office. It was performed in Clarkson's Nanoengineering and Biotechnology Laboratories Center (NABLAB), a unit led by Sokolov and established to promote cross-disciplinary collaborations within the University.

NABLAB comprises more than a dozen faculty members who apply the expertise of Clarkson scholars to cancer cell research, fine particles for bio and medical applications, synthesis of smart materials, advancement biosensors, and more.

####

About Clarkson University
Clarkson University launches leaders into the global economy. One in six alumni already leads as a CEO, VP or equivalent senior executive of a company. Located just outside the Adirondack Park in Potsdam, N.Y., Clarkson is a nationally recognized research university for undergraduates with select graduate programs in signature areas of academic excellence directed toward the world's pressing issues. Through 50 rigorous programs of study in engineering, business, arts, sciences and health sciences, the entire learning-living community spans boundaries across disciplines, nations and cultures to build powers of observation, challenge the status quo, and connect discovery and engineering innovation with enterprise.

For more information, please click here

Contacts:
Michael P. Griffin
Director of News & Digital Content Services
15-268-6716

Copyright © Clarkson University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

New approach to determining how atoms are arranged in materials August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Possible Futures

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Academic/Education

AIM Photonics Announces Release of Process Design Kit (PDK) for Integrated Silicon Photonics Design August 25th, 2016

Nanotech Security Featured by Simon Fraser University: Company's Anti-Counterfeiting Technology Developed With the Help of University's 4D LABS Materials Research Institute August 21st, 2016

W.M. Keck Foundation awards Cal State LA a $375,000 research and education grant August 4th, 2016

Thomas Swan and NGI announce unique partnership July 28th, 2016

Nanomedicine

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

Discoveries

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Nanofur for oil spill cleanup: Materials researchers learn from aquatic ferns: Hairy plant leaves are highly oil-absorbing / publication in bioinspiration & biomimetics / video on absorption capacity August 25th, 2016

Unraveling the crystal structure of a -70 Celsius superconductor, a world first: Significant advancement in the realization of room-temperature superconductors August 25th, 2016

Materials/Metamaterials

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Nanofur for oil spill cleanup: Materials researchers learn from aquatic ferns: Hairy plant leaves are highly oil-absorbing / publication in bioinspiration & biomimetics / video on absorption capacity August 25th, 2016

Unraveling the crystal structure of a -70 Celsius superconductor, a world first: Significant advancement in the realization of room-temperature superconductors August 25th, 2016

Announcements

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Environment

Nanofur for oil spill cleanup: Materials researchers learn from aquatic ferns: Hairy plant leaves are highly oil-absorbing / publication in bioinspiration & biomimetics / video on absorption capacity August 25th, 2016

Researchers watch catalysts at work August 19th, 2016

Down to the wire: ONR researchers and new bacteria August 18th, 2016

SLAC, Stanford gadget grabs more solar energy to disinfect water faster: Plopped into water, a tiny device triggers the formation of chemicals that kill microbes in minutes August 15th, 2016

Quantum Dots/Rods

Quantum dots with impermeable shell: A powerful tool for nanoengineering August 12th, 2016

Diamond-based light sources will lay a foundation for quantum communications of the future: Electrified quantum diamond can become the heart of quantum networks and computers of the future August 7th, 2016

A new type of quantum bits July 29th, 2016

Researchers develop faster, precise silica coating process for quantum dot nanorods July 12th, 2016

Nanobiotechnology

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic