Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Clarkson University Professor Synthesizes Brightest Fluorescent Nanoparticles Applications in material science, medicine and biology

Transmission electron microscopy (TEM) image of an ultrabright fluorescent mesoporous silica nanoparticle (image colored artificially to match the actual color of the dye in the particles).
Transmission electron microscopy (TEM) image of an ultrabright fluorescent mesoporous silica nanoparticle (image colored artificially to match the actual color of the dye in the particles).

Abstract:
Clarkson University Physics Professor Igor Sokolov and his team have discovered a method of making the brightest ever synthesized fluorescent silica nanoparticles.

Clarkson University Professor Synthesizes Brightest Fluorescent Nanoparticles Applications in material science, medicine and biology

Potsdam, NY | Posted on January 17th, 2011

The scientists reported on the first successful approach to synthesizing ultrabright fluorescent mesoporous silica nanoparticles this fall in the leading interdisciplinary scientific journal Small.

You can see the full article at onlinelibrary.wiley.com/doi/10.1002/smll.201001337/abstract

These nanoparticles have potential applications in medicine, biology, material science, and environmental protection, among many other uses.

Fluorescent materials are already used in many of these applications. However, having much brighter labeling particles will allow much finer detection of environmental pollutants, signals in biosensors and even the detection of explosives.

In fluorescence, an initial ignition light energizes molecules, and then the molecules reemit the light with a different color. This phenomenon can be used in many different applications because it is easily detectable, using optical filters to remove the ignition light, leaving only the particles' light visible.

"The particles should have a significant impact in the biomedical area," says Sokolov. "For example, you can create particles of different colors, which can be made to stick to particular biological molecules inside cells. Then you can see and trace those molecules easily with existing fluorescent microscopes. This fluorescent labeling helps to identify diseased cells and may show what is causing the disease. The particles are much more stable against photo-beaching than typical fluorescent dye. This means that one can trace the particles for a very long time."

Sokolov's process physically entraps a large number of organic fluorescent molecules inside nanoporous silica particles, which can be 20 to 50 nanometers in diameter, while preventing the molecules from leaking.

As an example of their brightness, the fluorescence of 40-nanometer particles is 34 times brighter than the brightest water-dispersible (25-30 nanometer) quantum dots and seem to be the brightest nanoparticles created so far.

In 2007, Sokolov and his team discovered a method of making the brightest ever synthesized fluorescent silica micro (non-nano) particles. Various attempts to decrease the size of the particles down to the nanoscale led to the particles that were bright but not ultrabright. The problem was in the dye leakage. It took the group several years to finally synthesize the ultrabright nanoparticles.

Sokolov and postdoctoral fellow Eun-Bum Cho (now an assistant professor at Seoul National University of Science and Technology) and Ph.D. student Dmytro Volkov developed the process, which gives the desired nanoparticles. The group, which now includes postdoctoral fellow Shajesh Palantavida, is currently looking at the development of the particles suitable for biomedical labeling.

The research was partially supported by the National Science Foundation and the U.S. Army Research Laboratory's Army Research Office. It was performed in Clarkson's Nanoengineering and Biotechnology Laboratories Center (NABLAB), a unit led by Sokolov and established to promote cross-disciplinary collaborations within the University.

NABLAB comprises more than a dozen faculty members who apply the expertise of Clarkson scholars to cancer cell research, fine particles for bio and medical applications, synthesis of smart materials, advancement biosensors, and more.

####

About Clarkson University
Clarkson University launches leaders into the global economy. One in six alumni already leads as a CEO, VP or equivalent senior executive of a company. Located just outside the Adirondack Park in Potsdam, N.Y., Clarkson is a nationally recognized research university for undergraduates with select graduate programs in signature areas of academic excellence directed toward the world's pressing issues. Through 50 rigorous programs of study in engineering, business, arts, sciences and health sciences, the entire learning-living community spans boundaries across disciplines, nations and cultures to build powers of observation, challenge the status quo, and connect discovery and engineering innovation with enterprise.

For more information, please click here

Contacts:
Michael P. Griffin
Director of News & Digital Content Services
15-268-6716

Copyright © Clarkson University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Graphene chips are close to significant commercialization October 1st, 2014

Govt.-Legislation/Regulation/Funding/Policy

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

NREL Announces New Center Directors to lead R&D, Analysis Efforts September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

UT Arlington researchers develop transparent nanoscintillators for radiation detection for medical safety and homeland security September 29th, 2014

Possible Futures

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Academic/Education

Yale University and Leica Microsystems Partner to Establish Microscopy Center of Excellence: Yale Welcomes Scientists to Participate in Core Facility Opening and Super- Resolution Workshops October 20 Through 31, 2014 September 30th, 2014

Rice launches Center for Quantum Materials: RCQM will immerse global visitors in cross-disciplinary research September 30th, 2014

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

Malvern technology delivers Malvern reliability in multi-disciplinary lab at Queen Mary University London September 9th, 2014

Nanomedicine

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Ad-REIC vaccine: A magic bullet for cancer treatment September 30th, 2014

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Discoveries

Nanoparticles Accumulate Quickly in Wetland Sediment: Aquatic food chains might be harmed by molecules "piggybacking" on carbon nanoparticles October 1st, 2014

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Materials/Metamaterials

Rice launches Center for Quantum Materials: RCQM will immerse global visitors in cross-disciplinary research September 30th, 2014

How things coil: Researchers discover that simulation technology designed for Hollywood can be used as a predictive tool for understanding fundamental engineering problems September 29th, 2014

Iranian Scientists Determine Grain Size, Minimize Time of Nanocomposite Synthesis September 29th, 2014

Nanoparticles Used to Improve Quality of Bone Cement September 29th, 2014

Announcements

'Stealth' nanoparticles could improve cancer vaccines October 1st, 2014

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail October 1st, 2014

New Absorber Will Lead to Better Biosensor: Biosensors are more sensitive and able to detect smaller changes in the environment October 1st, 2014

Graphene chips are close to significant commercialization October 1st, 2014

Environment

Nanoparticles Accumulate Quickly in Wetland Sediment: Aquatic food chains might be harmed by molecules "piggybacking" on carbon nanoparticles October 1st, 2014

Production of Filters for Separation of Water from Petroleum Products in Iran October 1st, 2014

On the Road to Artificial Photosynthesis: Berkeley Lab Study Reveals Key Catalytic Factors in Carbon Dioxide Reduction September 25th, 2014

World's smallest reference material is big plus for nanotechnology September 25th, 2014

Quantum Dots/Rods

University of Electro-Communications research: High density quantum dots for powerful solar cells September 25th, 2014

Nano-pea pod model widens electronics applications: A new theoretical model explains how a nanostructure, such as the nano-pea pod, can exhibit localised electrons September 4th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

NANOPARTICLES INDIA August 8th, 2014

Nanobiotechnology

Ad-REIC vaccine: A magic bullet for cancer treatment September 30th, 2014

How things coil: Researchers discover that simulation technology designed for Hollywood can be used as a predictive tool for understanding fundamental engineering problems September 29th, 2014

Penn Team Studies Nanocrystals by Passing Them Through Tiny Pores September 26th, 2014

New NIH/DOE Grant for Life Science Studies at NSLS-II: Funding will support operation of three powerful experimental stations designed to reveal detailed structures of proteins, viruses, and more September 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE