Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Flares on the Move

Abstract:
Nanoparticle test kit shows how nanoparticles of different size disperse in tumor tissue

Flares on the Move

Weinheim, Germany | Posted on January 11th, 2011

Nanoparticles play a significant role in the development of future diagnostic and therapeutic techniques for tumors, for example as transporters for drugs or as contrast agents. Absorption and dispersion of nanoparticles in tumor tissue depend strongly on particle size. In order to systematically study this, scientists at the Massachusetts Institute of Technology (MIT, Cambridge, USA) and Harvard Medical School (Boston, USA) have now produced a set of fluorescent nanoparticles of various diameters between 10 and 150 nm. As the team led by Moungi G. Bawendi and Daniel G. Nocera reports in the journal Angewandte Chemie, they were able to use these to simultaneously follow the dispersion of particles of different sizes through mouse tumors in real time.

In order for nanoparticle-based biomedical techniques to work, the nanoparticles must be of optimal size. For studies, it is thus desirable to simultaneously observe the behavior of particles of different size in the same tumor in vivo. This requires chemically comparable particles of various sizes, each size group consisting of particles of uniform size and composition. Additionally, it must be possible to simultaneously detect and differentiate the various particles. Also, they must be biocompatible, and may not form aggregates or adsorb proteins. This complex challenge has now been met.

The researchers developed a set of nanoparticles in various sizes, which can be detected by means of fluorescing quantum dots. Quantum dots are semiconducting structures at the boundary between macroscopic solid bodies and the quantum-mechanical nano-world. By selectively producing quantum dots of different sizes, it is possible to obtain quantum dots that fluoresce at different defined wavelengths, which allows them to be simultaneously detected and differentiated.

To produce nanoparticles in different size classes, the scientists coated cadmium selenide/cadmium sulfide quantum dots with polymer ligands such as silicon dioxide and polyethylene glycol. They attained particles larger than 100 nm in diameter by attaching quantum dots to prefabricated silicon dioxide particles and then coating them with polyethylene glycol. For each size class they selected quantum dots that give off light of a different wavelength.

The researchers intravenously injected a mixture of particles with diameters of 12, 60, and 125 nm into mice with cancer. Fluorescence microscopy was used to follow the particles' entry into the tumor tissue in vivo. Whereas the 12 nm particles easily passed from the blood vessels into the tissue and rapidly spread out, the 60 nm particles passed through the walls of the vein but stayed within 10 µm of the vessel wall, unable to pass farther into the tissue. The 125 nm particles essentially did not pass through the walls of the blood vessels at all.

Author: Moungi G. Bawendi, Daniel G. Nocera, Massachusetts Institute of Technology, Cambridge (USA), web.mit.edu/chemistry/www/faculty/nocera.html

Title: A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Angewandte Chemie International Edition 2010, 49, No. 46, 8649-8652, Permalink to the article: dx.doi.org/10.1002/anie.201003142

####

For more information, please click here

Copyright © Angewandte Chemie International Edition

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Possible Futures

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Research opens door to smaller, cheaper, more agile communications tech February 16th, 2017

Nanomedicine

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Meta-lenses bring benchtop performance to small, hand-held spectrometer: Game-changing nanostructure-based lenses allow smaller devices, increased functionality February 9th, 2017

Announcements

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Quantum Dots/Rods

Carbon dots dash toward 'green' recycling role: Rice scientists, colleagues use doped graphene quantum dots to reduce carbon dioxide to fuel December 18th, 2016

Two electrons go on a quantum walk and end up in a qudit: Russian scientists find a way to reliably connect quantum elements December 13th, 2016

Trickling electrons: Close to absolute zero, the particles exhibit their quantum nature November 10th, 2016

Notre Dame researchers find transition point in semiconductor nanomaterials September 6th, 2016

Nanobiotechnology

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Nanobiotix appoints senior executive from pharmaceutical industry, as Chief Operating Officer: Oncology industry veteran to oversee operations and product commercialization February 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project