Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Flares on the Move

Abstract:
Nanoparticle test kit shows how nanoparticles of different size disperse in tumor tissue

Flares on the Move

Weinheim, Germany | Posted on January 11th, 2011

Nanoparticles play a significant role in the development of future diagnostic and therapeutic techniques for tumors, for example as transporters for drugs or as contrast agents. Absorption and dispersion of nanoparticles in tumor tissue depend strongly on particle size. In order to systematically study this, scientists at the Massachusetts Institute of Technology (MIT, Cambridge, USA) and Harvard Medical School (Boston, USA) have now produced a set of fluorescent nanoparticles of various diameters between 10 and 150 nm. As the team led by Moungi G. Bawendi and Daniel G. Nocera reports in the journal Angewandte Chemie, they were able to use these to simultaneously follow the dispersion of particles of different sizes through mouse tumors in real time.

In order for nanoparticle-based biomedical techniques to work, the nanoparticles must be of optimal size. For studies, it is thus desirable to simultaneously observe the behavior of particles of different size in the same tumor in vivo. This requires chemically comparable particles of various sizes, each size group consisting of particles of uniform size and composition. Additionally, it must be possible to simultaneously detect and differentiate the various particles. Also, they must be biocompatible, and may not form aggregates or adsorb proteins. This complex challenge has now been met.

The researchers developed a set of nanoparticles in various sizes, which can be detected by means of fluorescing quantum dots. Quantum dots are semiconducting structures at the boundary between macroscopic solid bodies and the quantum-mechanical nano-world. By selectively producing quantum dots of different sizes, it is possible to obtain quantum dots that fluoresce at different defined wavelengths, which allows them to be simultaneously detected and differentiated.

To produce nanoparticles in different size classes, the scientists coated cadmium selenide/cadmium sulfide quantum dots with polymer ligands such as silicon dioxide and polyethylene glycol. They attained particles larger than 100 nm in diameter by attaching quantum dots to prefabricated silicon dioxide particles and then coating them with polyethylene glycol. For each size class they selected quantum dots that give off light of a different wavelength.

The researchers intravenously injected a mixture of particles with diameters of 12, 60, and 125 nm into mice with cancer. Fluorescence microscopy was used to follow the particles' entry into the tumor tissue in vivo. Whereas the 12 nm particles easily passed from the blood vessels into the tissue and rapidly spread out, the 60 nm particles passed through the walls of the vein but stayed within 10 Ám of the vessel wall, unable to pass farther into the tissue. The 125 nm particles essentially did not pass through the walls of the blood vessels at all.

Author: Moungi G. Bawendi, Daniel G. Nocera, Massachusetts Institute of Technology, Cambridge (USA), web.mit.edu/chemistry/www/faculty/nocera.html

Title: A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Angewandte Chemie International Edition 2010, 49, No. 46, 8649-8652, Permalink to the article: dx.doi.org/10.1002/anie.201003142

####

For more information, please click here

Copyright © Angewandte Chemie International Edition

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

'Lasers rewired': Scientists find a new way to make nanowire lasers: Berkeley Lab, UC Berkeley scientists adapt next-gen solar cell materials for a different purpose February 12th, 2016

Breaking cell barriers with retractable protein nanoneedles: Adapting a bacterial structure, Wyss Institute researchers develop protein actuators that can mechanically puncture cells February 12th, 2016

Replacement of Toxic Antibacterial Agents Possible by Biocompatible Polymeric Nanocomposites February 12th, 2016

Properties of Polymeric Nanofibers Optimized to Treat Damaged Body Tissues February 12th, 2016

Possible Futures

'Lasers rewired': Scientists find a new way to make nanowire lasers: Berkeley Lab, UC Berkeley scientists adapt next-gen solar cell materials for a different purpose February 12th, 2016

Breaking cell barriers with retractable protein nanoneedles: Adapting a bacterial structure, Wyss Institute researchers develop protein actuators that can mechanically puncture cells February 12th, 2016

Replacement of Toxic Antibacterial Agents Possible by Biocompatible Polymeric Nanocomposites February 12th, 2016

Properties of Polymeric Nanofibers Optimized to Treat Damaged Body Tissues February 12th, 2016

Nanomedicine

Breaking cell barriers with retractable protein nanoneedles: Adapting a bacterial structure, Wyss Institute researchers develop protein actuators that can mechanically puncture cells February 12th, 2016

Replacement of Toxic Antibacterial Agents Possible by Biocompatible Polymeric Nanocomposites February 12th, 2016

Properties of Polymeric Nanofibers Optimized to Treat Damaged Body Tissues February 12th, 2016

SLAC X-ray laser turns crystal imperfections into better images of important biomolecules: New method could remove major obstacles to studying structures of complex biological machines February 11th, 2016

Announcements

Graphene leans on glass to advance electronics: Scientists' use of common glass to optimize graphene's electronic properties could improve technologies from flat screens to solar cells February 12th, 2016

Breaking cell barriers with retractable protein nanoneedles: Adapting a bacterial structure, Wyss Institute researchers develop protein actuators that can mechanically puncture cells February 12th, 2016

Replacement of Toxic Antibacterial Agents Possible by Biocompatible Polymeric Nanocomposites February 12th, 2016

Properties of Polymeric Nanofibers Optimized to Treat Damaged Body Tissues February 12th, 2016

Quantum Dots/Rods

Nanoscale cavity strongly links quantum particles: Single photons can quickly modify individual electrons embedded in a semiconductor chip and vice versa February 8th, 2016

The iron stepping stones to better wearable tech without semiconductors February 8th, 2016

QD Vision Named to the 2015 Global Cleantech 100 Under the Radar List: Quantum Dot Leader Recognized for Clean Technology Innovation January 26th, 2016

Light-activated nanoparticles prove effective against antibiotic-resistant 'superbugs' January 19th, 2016

Nanobiotechnology

Breaking cell barriers with retractable protein nanoneedles: Adapting a bacterial structure, Wyss Institute researchers develop protein actuators that can mechanically puncture cells February 12th, 2016

Replacement of Toxic Antibacterial Agents Possible by Biocompatible Polymeric Nanocomposites February 12th, 2016

Properties of Polymeric Nanofibers Optimized to Treat Damaged Body Tissues February 12th, 2016

SLAC X-ray laser turns crystal imperfections into better images of important biomolecules: New method could remove major obstacles to studying structures of complex biological machines February 11th, 2016

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic