Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > From Molecule to Object

Pushing the limits: A 200×106 Da structurally defined, linear macromolecule (PG5) has a molar mass, cross-section dimension, and cylindrical shape that are comparable to some naturally occurring objects, such as amyloid fibrils or certain plant viruses. The macromolecule is resistant against flattening out on a surface; the picture shows PG5 embracing the tobacco mosaic virus (TMV).
Pushing the limits: A 200×106 Da structurally defined, linear macromolecule (PG5) has a molar mass, cross-section dimension, and cylindrical shape that are comparable to some naturally occurring objects, such as amyloid fibrils or certain plant viruses. The macromolecule is resistant against flattening out on a surface; the picture shows PG5 embracing the tobacco mosaic virus (TMV).

Abstract:
Largest synthetic structure with molecular precision

From Molecule to Object

Weinheim, Germany | Posted on January 4th, 2011

Organic Chemists have always been trying to imitate biology. Although it is possible to make many molecules that imitate biomolecules in terms of structure and function, it remains a challenge to attain the size and form of large biomolecules. An international team led by A. Dieter Schlüter at the ETH Zurich (Switzerland) has now introduced a branched polymer that resembles the tobacco mosaic virus in size and cylindrical form. As the researchers outline in the journal Angewandte Chemie, this is the largest synthetic macromolecule with defined shape and atomic structure reported to date.

Previously, the largest reported synthetic structures with a defined atomic structure were polystyrene polymers with a molecular mass of about 40 million Daltons. However, this value corresponds to a small fraction of the mass of large DNA molecules. Formation of a large synthetic molecule that also has a defined form is much more difficult. For biologists, however, it is routine. Even the simplest organism has a well-defined form, such as the rod-shaped tobacco mosaic virus. For chemists it is a model: a massive molecular ensemble with perfect control over its chemical structure, function, size, and molecular form.

Schlüter and co-workers have now presented a branched polymer that approximates the size and form of the tobacco mosaic virus. Their complex synthesis, which requires 170,000 bond-forming reactions in a single molecule, led to a structurally defined, linear macromolecule with a diameter of about 10 nm and a molecular weight of 200 million Daltons. It thus has a molar mass, cross section, and cylindrical form comparable to the tobacco mosaic virus.

The new macromolecule is a dendronized polymer: it consists of a linear backbone with highly and regularly branched side chains. "This is the biggest synthetic macromolecule with a defined chemical structure and defined form to date," according to Schlüter. "Our experiment is a first step toward the synthesis of molecular objects." A structure is considered to be an object if it keeps its form regardless of its environment, when its interior can be distinguished from the outer environment, and when there is a clear boundary between the two. There are many synthetic nano-objects, however these are not single molecules, but are aggregates of several or many individual molecules.

Author: A. Dieter Schlüter, ETH Zürich (Switzerland), www.polychem.mat.ethz.ch/people/head/dieters

Title: The Largest Synthetic Structure with Molecular Precision: Towards a Molecular Object

Angewandte Chemie International Edition, Permalink: dx.doi.org/10.1002/anie.201005164

####

For more information, please click here

Copyright © Angewandte Chemie

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad 2018 September 20th, 2018

Chemistry

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

How a tetrahedral substance can be more symmetrical than a spherical atom: A new type of symmetry September 14th, 2018

Terahertz spectroscopy enters the single-molecule regime September 7th, 2018

Peering into private life of atomic clusters -- using the world's tiniest test tubes September 6th, 2018

Possible Futures

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Leti Announces EU Project to Develop Powerful, Inexpensive Sensors with Photonic Integrated Circuits: REDFINCH Members Initially Targeting Applications for Gas Detection and Analysis For Refineries & Petrochemical Industry and Protein Analysis for Dairy Industry September 19th, 2018

Academic/Education

The Institute of Applied Physics at the University of Tsukuba near Tokyo in Japan uses Deben's ARM2 detector to better understand catalytic reaction mechanisms June 27th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

SUNY Poly Professor Eric Lifshin Selected for ‘Fellow of the Microanalysis Society’ Position for Significant Contributions to Microanalysis June 13th, 2018

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Announcements

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad 2018 September 20th, 2018

Nanobiotechnology

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad 2018 September 20th, 2018

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project