Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Microsensors Offer First Look at Whether Cell Mass Affects Growth Rate

Abstract:
Researchers at the University of Illinois, Urbana-Champaign, have developed a new kind of microsensor to answer one of the weightiest questions in biology - the relationship between cell mass and growth rate.

Microsensors Offer First Look at Whether Cell Mass Affects Growth Rate

Bethesda, MD | Posted on December 17th, 2010

The team, led by Rashid Bashir, published its results in the Proceedings of the National Academy of Sciences. Dr. Bashir is the co-principal investigator of one of six Cancer Nanotechnology Training Centers funded by the National Cancer Institute Alliance for Nanotechnology in Cancer.

Biologists have long questioned whether cells grow at a fixed rate or whether growth accelerates as mass increases. But the mechanics of cellular growth and division are important not only for basic biology, but also for diagnostics, drug development, tissue engineering and understanding cancer. For example, documenting these processes could help identify specific drug targets to slow or stop the uncontrolled growth of cancer cells.

Previous studies have used aggregate populations of cells, making it impossible to determine patterns of individual cell growth. With their small, sensitive microsensors, Dr. Bashir and his colleagues were able to track individual colon cancer cells' masses and divisions over time. The investigators found that the cells they studied did grow faster as they grew heavier, rather than growing at the same rate throughout the cell cycle.

Each microsensor is a tiny, suspended platform made in silicon on a chip. The suspended scale vibrates at a particular frequency, which changes when mass is added. As a cell's mass increases, the sensor's resonant frequency goes down. "As you make the structure smaller and smaller, it becomes more sensitive to the mass that's placed on it," Dr. Bashir said. "A cell is a few nanograms in mass or smaller. If we can make our sensor small enough, then it becomes sensitive to cell mass."

The researchers created an array of hundreds of sensors on a chip. They can culture cells on the chip in much the same way that scientists grow cells in a dish. Thus, they can collect data from many cells at once, while still recording individual cellular measurements. Another advantage of these microsensors is the ability to image cells with microscopes while cells grow on the sensors. Researchers can track the cells visually, opening the possibilities of tracking various cellular processes in conjunction with changes in mass. "Imaging acts as a control. You can actually watch the cell divide and grow and correlate that to your measurements. It really validates what you have," explained Dr. Bashir. "There are lots of optical measurements that now you can integrate with mass sensing."

Next, the researchers plan to extend the study to other cell lines, and explore more optical measurements and fluorescent markers. "These technologies can also be used for diagnostic purposes, or for screening. For example, we could study cell growth and mass and changes in the cell structure based on drugs or chemicals," Bashir said.

This work is detailed in a paper titled, "Measurement of adherent cell mass and growth." An abstract of this paper is available at the journal's website.

View abstract at www.pnas.org/content/107/48/20691

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Crystalline Fault Lines Provide Pathway for Solar Cell Current: New tomographic AFM imaging technique reveals that microstructural defects, generally thought to be detrimental, actually improve conductivity in cadmium telluride solar cells September 26th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

PHENOMEN is a FET-Open Research Project aiming to lay the foundations a new information technology September 19th, 2016

NIST Patents Single-Photon Detector for Potential Encryption and Sensing Apps September 16th, 2016

Possible Futures

Crystalline Fault Lines Provide Pathway for Solar Cell Current: New tomographic AFM imaging technique reveals that microstructural defects, generally thought to be detrimental, actually improve conductivity in cadmium telluride solar cells September 26th, 2016

Researchers at the Catalan Institute of Nanoscience and Nanotechnology show that bending semiconductors generates electricity September 26th, 2016

Chains of nanogold – forged with atomic precision September 23rd, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Academic/Education

PHENOMEN is a FET-Open Research Project aiming to lay the foundations a new information technology September 19th, 2016

AIM Photonics Announces Release of Process Design Kit (PDK) for Integrated Silicon Photonics Design August 25th, 2016

Nanotech Security Featured by Simon Fraser University: Company's Anti-Counterfeiting Technology Developed With the Help of University's 4D LABS Materials Research Institute August 21st, 2016

W.M. Keck Foundation awards Cal State LA a $375,000 research and education grant August 4th, 2016

Nanomedicine

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

BBI Solutions launches innovative conjugate blocking technology that enhances signal intensity for lateral flow immunoassays September 20th, 2016

Sensors

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Researchers at the Catalan Institute of Nanoscience and Nanotechnology show that bending semiconductors generates electricity September 26th, 2016

Chains of nanogold – forged with atomic precision September 23rd, 2016

Speedy bacteria detector could help prevent foodborne illnesses September 21st, 2016

Announcements

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Nanobiotechnology

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

BBI Solutions launches innovative conjugate blocking technology that enhances signal intensity for lateral flow immunoassays September 20th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic