Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Microsensors Offer First Look at Whether Cell Mass Affects Growth Rate

Abstract:
Researchers at the University of Illinois, Urbana-Champaign, have developed a new kind of microsensor to answer one of the weightiest questions in biology - the relationship between cell mass and growth rate.

Microsensors Offer First Look at Whether Cell Mass Affects Growth Rate

Bethesda, MD | Posted on December 17th, 2010

The team, led by Rashid Bashir, published its results in the Proceedings of the National Academy of Sciences. Dr. Bashir is the co-principal investigator of one of six Cancer Nanotechnology Training Centers funded by the National Cancer Institute Alliance for Nanotechnology in Cancer.

Biologists have long questioned whether cells grow at a fixed rate or whether growth accelerates as mass increases. But the mechanics of cellular growth and division are important not only for basic biology, but also for diagnostics, drug development, tissue engineering and understanding cancer. For example, documenting these processes could help identify specific drug targets to slow or stop the uncontrolled growth of cancer cells.

Previous studies have used aggregate populations of cells, making it impossible to determine patterns of individual cell growth. With their small, sensitive microsensors, Dr. Bashir and his colleagues were able to track individual colon cancer cells' masses and divisions over time. The investigators found that the cells they studied did grow faster as they grew heavier, rather than growing at the same rate throughout the cell cycle.

Each microsensor is a tiny, suspended platform made in silicon on a chip. The suspended scale vibrates at a particular frequency, which changes when mass is added. As a cell's mass increases, the sensor's resonant frequency goes down. "As you make the structure smaller and smaller, it becomes more sensitive to the mass that's placed on it," Dr. Bashir said. "A cell is a few nanograms in mass or smaller. If we can make our sensor small enough, then it becomes sensitive to cell mass."

The researchers created an array of hundreds of sensors on a chip. They can culture cells on the chip in much the same way that scientists grow cells in a dish. Thus, they can collect data from many cells at once, while still recording individual cellular measurements. Another advantage of these microsensors is the ability to image cells with microscopes while cells grow on the sensors. Researchers can track the cells visually, opening the possibilities of tracking various cellular processes in conjunction with changes in mass. "Imaging acts as a control. You can actually watch the cell divide and grow and correlate that to your measurements. It really validates what you have," explained Dr. Bashir. "There are lots of optical measurements that now you can integrate with mass sensing."

Next, the researchers plan to extend the study to other cell lines, and explore more optical measurements and fluorescent markers. "These technologies can also be used for diagnostic purposes, or for screening. For example, we could study cell growth and mass and changes in the cell structure based on drugs or chemicals," Bashir said.

This work is detailed in a paper titled, "Measurement of adherent cell mass and growth." An abstract of this paper is available at the journal's website.

View abstract at www.pnas.org/content/107/48/20691

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Possible Futures

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

Nanocoatings Market By Product Is Expected To Reach USD 8.17 Billion By 2020: Grand View Research, Inc. October 15th, 2014

Perpetuus Carbon Group Receives Independent Verification of its Production Capacity for Graphenes at 140 Tonnes per Annum: Perpetuus Becomes the First Manufacturer in the Sector to Allow Third Party Audit October 7th, 2014

Academic/Education

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Raytheon, UMass Lowell open on-campus research institute: Industry leader’s researchers to collaborate with faculty, students to move key technologies forward through first-of-its-kind partnership October 11th, 2014

SUNY Colleges of Nanoscale Science and Engineering and National Institute for Occupational Safety and Health Announce Expanded Partnership October 2nd, 2014

Yale University and Leica Microsystems Partner to Establish Microscopy Center of Excellence: Yale Welcomes Scientists to Participate in Core Facility Opening and Super- Resolution Workshops October 20 Through 31, 2014 September 30th, 2014

Nanomedicine

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Sensors

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Graphenea opens US branch October 16th, 2014

IRLYNX and CEA-Leti to Streamline New CMOS-based Infrared Sensing Modules Dedicated to Human-activities Characterization October 15th, 2014

Announcements

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Nanobiotechnology

Mechanism behind nature's sparkles revealed October 22nd, 2014

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Scientists Map Key Moment in Assembly of DNA-Splitting Molecular Machine: Crucial steps and surprising structures revealed in the genesis of the enzyme that divides the DNA double helix during cell replication October 15th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE