Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Silicon-Nested Gadonanotubes Promise Big

ac, Schematic showing Magnevist (a), GFs (b) and debundled GNTs (c). d,e, Scanning electron micrographs of quasi-hemispherical (H-SiMP: diameter, 1.6 m; thickness, ~0.6 m) (d) and discoidal (D-SiMP: diameter, 1.0 m; thickness, 0.4 m). Credit Nature
ac, Schematic showing Magnevist (a), GFs (b) and debundled GNTs (c). d,e, Scanning electron micrographs of quasi-hemispherical (H-SiMP: diameter, 1.6 m; thickness, ~0.6 m) (d) and discoidal (D-SiMP: diameter, 1.0 m; thickness, 0.4 m). Credit Nature

Abstract:
A porous, disk-shaped "nest" for nanotubes may help magnetic resonance imaging become better than ever at finding evidence of cancer if the results of research led by investigators at Rice University are any indication of future success.

Silicon-Nested Gadonanotubes Promise Big

Bethesda, MD | Posted on December 17th, 2010

This research team, which also included colleagues from other Texas Medical Center institutions, as well as those in Colorado, Italy and Switzerland, have developed a general method for trapping paramagnetic nanoparticles inside a silicon particle that, when injected into a patient's bloodstream, would make the nanoparticles up to 50 times more effective at spotting tumors or other signs of disease. Paramagnetic contrast agents "light up" damaged tissue in the body in images produced by MRI instruments.

"Making MRIs better is no small matter," said Lon Wilson, one of three senior co-authors of the research paper published in the journal Nature Nanotechnology. The other senior co-authors include Mauro Ferrari, from the Methodist Hospital Research Institute, and Paolo Decuzzi, of the University of Texas Health Sciences Center at Houston. Drs. Ferrari and Decuzzi are members of the Texas Center for Cancer Nanomedicine, one of nice Centers of Cancer Nanotechnology Excellence funded by the National Cancer Institute's Alliance for Nanotechnology in Cancer.

In 2007, 28 million MRI scans were performed in the United States, and contrast agents were used in nearly 45 percent of them. "MRI is one of the most powerful medical tools for imaging, if not the most powerful," said Dr. Wilson. "It's not invasive, it's not ionizing harmful radiation, and the resolution is the best you can get in medical imaging." MRI's main limitation is its sensitivity. "So anything you can do to improve performance and increase sensitivity is a big deal -- and that's what this does."

A nano-sized slice of silicon shaped like a hockey puck served as a delivery device for contrast agents in the study. Pores that were mere nanometers long and wide were created in the discs, called silicon microparticles, or SiMPs. Three types of contrast agents were drawn into the pores. Magnevist, a common contrast agent used worldwide, was one; the others were gadofullerenes and gadonanotubes. All three of these contrast agents chemically sequester the toxic element gadolinium to make it safe for injection.

MRIs work by manipulating hydrogen atoms in water, which interact and align with the applied magnetic field from the instrument. The hydrogen atoms are then allowed to return to their original magnetic state, a process called relaxation. In the presence of the paramagnetic gadolinium ion, the atoms' relaxation time is shortened, making these regions brighter against the background under MRI.

SiMPs are small and when they trap both water molecules and bundles of nanotubes containing gadolinium, the protons appear much brighter in an MR image. Because SiMPs keep their form for up to 24 hours before dissolving into harmless silicic acid, the molecules can be imaged for a long time. The trick, though, is getting them to places in the body that doctors and technicians want to see. Wilson said SiMPs are designed to escape the bloodstream, where they leak and aggregate at the sites of tumors and lesions. "Spherical particles, at least in mathematical models, flow down the center of the vasculature," he said. "These particles are designed to hug the wall. When they encounter a leaky area like a cancer tumor, they can easily get out."

The encapsulation within SiMPs enhanced the performance of all three contrast agents, but SiMPs with gadonanotubes (carbon nanotubes that contain bundles of gadolinium ions) showed the best results. "The performance was enhanced beyond what we had imagined," he said. SiMPs may also be functionalized with peptides that target cancer and other cells. SiMPs that contain contrast agents and anticancer agents could potentially be tracked as they home in on tumors, where the drugs would be released as the silicon dissolves.

This work is detailed in paper titled, "Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast." An abstract of this paper is available at the journal's website.

View abstract at www.nature.com/nnano/journal/v5/n11/full/nnano.2010.203.html

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with todays explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Chemists make new silicon-based nanomaterials March 27th, 2015

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Possible Futures

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanocomposites Market Growth, Industry Outlook To 2020 by Grand View Research, Inc. March 21st, 2015

Nanotechnology Drug Delivery Market in the US 2012-2016 : Latest Report Available by Radiant Insights, Inc March 16th, 2015

Academic/Education

LAMDAMAP 2015 hosted by the University March 26th, 2015

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

SUNY POLY CNSE to Host First Ever Northeast Semi Supply Conference (NESCO) Conference Will Connect New and Emerging Innovators in the Northeastern US and Canada with Industry Leaders and Strategic Investors to Discuss Future Growth Opportunities in NYS March 25th, 2015

FEI Joins University of Ulm and CEOS on SALVE Project Research Collaboration: The Sub-ngstrm Low Voltage Electron (SALVE) microscope should improve contrast and reduce damage on bio-molecules and two-dimensional nanomaterials, such as graphene March 18th, 2015

Nanotubes/Buckyballs

Carbon nanotube fibers make superior links to brain: Rice University invention provides two-way communication with neurons March 25th, 2015

Iranian Scientists Eliminate Expensive Materials from Diabetes Diagnosis Sensors March 25th, 2015

Effect of Carbon Nanotubes on Properties of Cement Composites Studied in Iran March 23rd, 2015

First proof of isolated attosecond pulse generation at the carbon K-edge March 20th, 2015

Nanomedicine

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Graphene reduces wear of alumina ceramic March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Announcements

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Nanobiotechnology

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Dolomites microfluidics technology ideal for B cell encapsulation March 24th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

TGAC's take on the first portable DNA sequencing 'laboratory': First remote laboratory allows researchers to conduct real-time anaylsis March 19th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE