Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Writing with a Nanoquill

Pen-pushing: Direct-write dip-pen nanolithography (DPN) using a tip coated with nanoporous poly(2-methyl-2-oxazoline) allows the creation of precise patterns of large-sized biomaterials such as viruses. The hydrogel tip absorbs the virus-containing ink solution and atomic force microscopy is used to transport it to a surface. Credit Angewandte Chemie
Pen-pushing: Direct-write dip-pen nanolithography (DPN) using a tip coated with nanoporous poly(2-methyl-2-oxazoline) allows the creation of precise patterns of large-sized biomaterials such as viruses. The hydrogel tip absorbs the virus-containing ink solution and atomic force microscopy is used to transport it to a surface. Credit Angewandte Chemie

Abstract:
Dip-pen nanolithography with a porous tip generates nanopatterns with viruses

Writing with a Nanoquill

Weinheim, Germany | Posted on December 8th, 2010

One process used to produce nanoscopic structures like ever-smaller integrated circuits, biosensors, and gene chips is known as dip-pen nanolithography, in which the nanotip of an atomic force microscope is used to "write" a pattern directly on a substrate. In the journal Angewandte Chemie, a Korean research team led by Jung-Hyurk Lim at Chungju National University in Chungju have now introduced a refined nanotip for this technique. With their "nanoquill", it is possible to produce complex nanopatterns from large biomolecules—such as complete virus particles—rapidly, precisely, and flexibly.

Atomic force microscopy, originally designed for the determination of the nanoscopic structures of surfaces, has since been very successfully put to another use: In dip-pen nanolithography, the nanotip is dipped like a quill into an "ink well" and the molecules are then deposited like ink onto a suitable substrate to form complex nanopatterns. Critical to this process is a tiny water meniscus that forms between the surface to be written on and the nanotip; the meniscus provides a pathway by which the molecules in the ink—DNA, peptides, or proteins—can move to the surface. However, larger molecules cannot diffuse through the meniscus and cannot be deposited on the surface. Thanks to a novel nanotip, the Korean scientists have now overcome this limitation. The new tip is made of silicon dioxide that has been coated with a well-characterized biocompatible polymer. This forms a nanoporous polymer network with pore diameters between 50 and several hundred nanometers.

When this tip is dipped into a solution containing biomolecules, the polymer absorbs the liquid and swells into a gel. When the loaded "nanoquill" comes into contact with an amine-coated substrate, the biomolecules diffuse out of the gel onto the surface. Because diffusion from the gel onto the surface encounters less resistance than diffusion through a water meniscus, it is possible to deposit much larger biomolecules than in the conventional method.

As a demonstration, the researchers selected virus particles bound to a fluorescence dye as their ink. They were able to use this to produce patterns with more than 1000 individual nanodots without having to refill the quill. Unlike the conventional technique, increasing contact time between the surface and the tip of the quill increases the number of individual viruses within the dot, but not its diameter. However, the researchers were able to generate dots of various sizes (400, 200, and 80 nm) by varying the diameter of the tip. This variation can be quite easily controlled by the duration of the polymerization reaction.

(2761 characters)

Author: Jung-Hyurk Lim, Chungju National University (Rep. Korea),

Title: Polymer-Coated Tips for Patterning of Viruses by Dip-Pen Nanolithography

Angewandte Chemie International Edition 2010, 49, No. 50, 9689-9692, Permalink to the article: dx.doi.org/10.1002/anie.201004654

####

For more information, please click here

Copyright © Angewandte Chemie

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Academic/Education

Global leader in solar cell manufacturing eyes New York for major expansion outside of Japan: CNSE and Solar Frontier Explore $700 Million Investment, Job Creation in New York State April 22nd, 2014

University of Waterloo Visits China to Strengthen Bonds With Research Partners April 21st, 2014

Director Wally Pfister joins UC Berkeley neuroengineers to discuss the science behind ‘Transcendence’ April 7th, 2014

First annual science week highlights STEM pipeline and partnerships: UB, SUNY Buffalo State and ECC team up with the City of Buffalo and its schools for April 7-11 events April 3rd, 2014

Announcements

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Tools

MRI, on a molecular scale: Researchers develop system that could one day peer into the atomic structure of individual molecules April 20th, 2014

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

Aerotech X-Y ball-screw stage for economical high performance Planar positioning April 16th, 2014

Nanobiotechnology

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Targeting cancer with a triple threat: MIT chemists design nanoparticles that can deliver three cancer drugs at a time April 15th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

In latest generation of tiny biosensors, size isn't everything: UCLA researchers overturn conventional wisdom on nanowire-based diagnostic devices April 11th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE