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Home > News > Aphios Awarded SBIR for Novel Alzheimer’s Disease Nanodrug

November 30th, 2010

Aphios Awarded SBIR for Novel Alzheimer’s Disease Nanodrug

Abstract:
Aphios® Corporation today announced that it was awarded Phase I of a Fast Track SBIR grant from the National Institute of Aging (NIA), National Institutes of Health (NIH) for Developing a Novel Alzheimer's Disease Nanodrug.

Recently, researchers have shown that sub-nanomolar concentrations of APH-0703, a potent PKC activator, can dramatically enhance the generation of non-amyloidogenic, soluble amyloid precursor protein (sAPP) in fibroblasts from AD patients.

Aphios manufactures pharmaceutical-grade APH-0703 following cGMP guidelines utilizing patented manufacturing technology. Aphios has also developed and patented improved methods for formulating the API into phospholipid nanosomes that can be utilized to enhance efficacy, reduce toxicity and improve quality-of-life, and polymer nanospheres for improving oral delivery and bioavailability.

Source:
sunherald.com

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