Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Early phase of atherosclerosis imaged

Nico Sommerdijk. Photo: Bart van Overbeeke.
Nico Sommerdijk. Photo: Bart van Overbeeke.

Abstract:
Atherosclerosis is characterized by hardening and thickening of artery walls, with serious health consequences. Researchers at TU/e have imaged the stages in the calcification at a nanometer scale. The growth of hardening follows almost the same process as bone or tooth formation. The results will be published in Nature Materials.

Early phase of atherosclerosis imaged

The Netherlands | Posted on November 21st, 2010

The images made by researcher Nico Sommerdijk (Laboratory of Materials and Interface Chemistry, Department of Chemical Engineering and Chemistry) and his team resolve a long-standing dispute. As long ago as 1965, Aaron S. Posner suggested in the journal Nature how the calcification - the formation of calcium phosphate - in a biological environment takes place, although this met with considerable resistance at the time, Sommerdijk explains.

However, his observations now confirm Posner's 45-year-old idea. Calcium and phosphate ions dissolved in the blood are not deposited directly as crystalline material on the artery wall, but first pass through an intermediate phase. In this phase they first form prenucleation clusters, followed by amorphous nanoparticles measuring approximately 50 nanometers (1 nanometer is a millionth of a millimeter). Only then does crystallization occur, causing hardening of the artery wall. The researchers hope that this understanding will be used to develop new forms of treatment for atherosclerosis.

Serum

Because atherosclerosis cannot be observed at a nanometer scale in living persons, the researchers used imitation serum - a fluid containing exactly the same substances as those found in the blood itself, except for the organic materials. The researchers placed this serum in contact with a membrane with the same characteristics as the artery wall, on which the process of calcification then began. They imaged the various steps of this process using a special electron microscope, the cryoTitan. This microscope allows researchers to observe very rapidly frozen samples at the level of individual atoms, so that a process can be arrested and viewed step-by-step.

All living beings

Sommerdijk has already showed that the process of shell growth and bone formation takes place in the same way as atherosclerosis. "It seems that all mineralization systems in living beings take place in the same way. And there are increasing indications that it works similarly everywhere", says Sommerdijk.

Three articles in Nature Materials

The publication will appear in the December edition of the leading scientific journal Nature Materials, which also contains another article by Nico Sommerdijk. This deals with understanding the mechanisms of bone growth; a related research project. According to the editors of Nature Materials it is rare for two publications by the same researcher to appear in the same edition of the journal. "It happens maybe once a year", says Alison Stoddart of Nature Materials. "Only five to ten per cent of the articles submitted are actually selected for publication. So if two are published at the same time it's quite a rare event." As well as the articles themselves, the journal is also publishing a two-page editorial in which an external specialist presents his own view of Sommerdijk's research findings.

The role of prenucleation clusters in surface-induced calcium phosphate crystallization. Archan Dey, Paul H.H. Bomans, Frank A. Müller, Julia Will, Peter M. Frederik, Gijsbertus de With and Nico A.J.M. Sommerdijk. The article has already been published in the online edition of Nature Materials on 14 November 2010.

####

For more information, please click here

Copyright © Technische Universiteit Eindhoven

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Physicists build reversible laser tractor beam October 20th, 2014

Removal of Limitations of Composites at Superheat Temperatures October 20th, 2014

1980s aircraft helps quantum technology take flight October 20th, 2014

Ucore's McKenzie to Deliver Presentation to Rare Earths Conference in Singapore as Highlight of Fall 2014 Marketplace Schedule October 19th, 2014

Academic/Education

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Raytheon, UMass Lowell open on-campus research institute: Industry leader’s researchers to collaborate with faculty, students to move key technologies forward through first-of-its-kind partnership October 11th, 2014

SUNY Colleges of Nanoscale Science and Engineering and National Institute for Occupational Safety and Health Announce Expanded Partnership October 2nd, 2014

Yale University and Leica Microsystems Partner to Establish Microscopy Center of Excellence: Yale Welcomes Scientists to Participate in Core Facility Opening and Super- Resolution Workshops October 20 Through 31, 2014 September 30th, 2014

Nanomedicine

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

European Commission opens the gate towards the implementation of Nanomedicine Translation Hub October 16th, 2014

Nanodevices for clinical diagnostic with potential for the international market: The development is based on optical principles and provides precision and allows saving vital time for the patient October 15th, 2014

Tuning light to kill deep cancer tumors: Nanoparticles developed at UMass Medical School advance potential clinical application for photodynamic therapy October 15th, 2014

Discoveries

Physicists build reversible laser tractor beam October 20th, 2014

Removal of Limitations of Composites at Superheat Temperatures October 20th, 2014

1980s aircraft helps quantum technology take flight October 20th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

Announcements

Physicists build reversible laser tractor beam October 20th, 2014

Removal of Limitations of Composites at Superheat Temperatures October 20th, 2014

1980s aircraft helps quantum technology take flight October 20th, 2014

Ucore's McKenzie to Deliver Presentation to Rare Earths Conference in Singapore as Highlight of Fall 2014 Marketplace Schedule October 19th, 2014

Nanobiotechnology

Scientists Map Key Moment in Assembly of DNA-Splitting Molecular Machine: Crucial steps and surprising structures revealed in the genesis of the enzyme that divides the DNA double helix during cell replication October 15th, 2014

DNA nano-foundries cast custom-shaped metal nanoparticles: DNA's programmable assembly is leveraged to form precise 3D nanomaterials for disease detection, environmental testing, electronics and beyond October 10th, 2014

Charged graphene gives DNA a stage to perform molecular gymnastics October 9th, 2014

Nanoparticles get a magnetic handle: New method produces particles that can glow with color-coded light and be manipulated with magnets October 9th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE