Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Tests show bright future for gadonanotubes in stem cell tracking

Dark spots are aggregates of gadonanotubes (GNTs) in the cytoplasm of a mesenchymal stem cell. Tests show GNTs are highly effective for tagging and tracking stem cells through magnetic resonance imaging. (Credit: Lesa Tran/Rice University)
Dark spots are aggregates of gadonanotubes (GNTs) in the cytoplasm of a mesenchymal stem cell. Tests show GNTs are highly effective for tagging and tracking stem cells through magnetic resonance imaging. (Credit: Lesa Tran/Rice University)

Abstract:
Gadonanotubes (GNTs) developed at Rice University are beginning to show positive results in a study funded by a federal stimulus grant through the National Institutes of Health (NIH) last year.

Tests show bright future for gadonanotubes in stem cell tracking

Houston, TX | Posted on November 12th, 2010

The study has determined GNTs are effective in helping doctors track stems cells through the body by making them 40 times better than standard contrast agents used in magnetic resonance imaging. Contrast agents help doctors spot signs of disease or damage in MR images.

Researchers at Rice and the Texas Heart Institute at St. Luke's Episcopal Hospital in Houston reported in the journal Biomaterials that mesenchymal stem cells drawn from pig bone marrow labeled with GNTs are easily spotted under MRI. The technique holds promise for tracking the progress of tagged cells as they travel through a patient's body.

Ultimately, the team hopes the magnetic properties of tagged stem cells will allow doctors to manipulate them in vivo and direct cells to specific locations -- in the heart, for instance -- where they can heal damaged tissue.

GNTs are carbon nanotubes that contain gadolinium, an element commonly used in designing contrast elements for use in MRI. Though toxic, gadolinium is chelated, or chemically bound, which makes it safer for injection into the body. But clinical agents like the gadolinium-based Magnevist cannot enter cells.

However, GNTs can. Invented in the lab of Rice chemistry professor Lon Wilson in 2005, the nanotubes sequester bundles of gadolinium ions, which enhance contrast in MRIs but cannot escape their carbon cages. This makes them biologically inert and safe for tagging cells from within.

The team found GNTs did not affect the stem cells' ability to differentiate into other types of cells or to self-renew, though work continues to characterize their ability to adhere to cell scaffolds under various conditions.

Lesa Tran, a fourth-year graduate student in Wilson's lab, was the primary author of the paper, and Wilson was corresponding author. Co-authors were Rice graduate student Ramkumar Krishnamurthy; Raja Muthupillai, a senior physicist at St. Luke's; and of the Texas Heart Institute: Maria da Graça Cabreira-Hansen, a research scientist; James Willerson, president and medical director; and Emerson Perin, medical director of the Stem Cell Center.

Primary funding for the project came from the $1 million NIH Challenge Grant, with additional funding by the National Science Foundation and the Robert A. Welch Foundation.

Read the abstract here: tinyurl.com/34fpb5m.

####

About Rice University
Located in Houston, Rice University is consistently ranked one of America's best teaching and research universities. Known for its "unconventional wisdom," Rice is distinguished by its: size -- 3,279 undergraduates and 2,277 graduate students; selectivity -- 12 applicants for each place in the freshman class; resources -- an undergraduate student-to-faculty ratio of 5-to-1; sixth largest endowment per student among American private research universities; residential college system, which builds communities that are both close-knit and diverse; and collaborative culture, which crosses disciplines, integrates teaching and research, and intermingles undergraduate and graduate work.

For more information, please click here

Contacts:
David Ruth
713-348-6327


Mike Williams
713-348-6728

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Evidence mounts for quantum criticality theory: Findings bolster theory that quantum fluctuations drive strange electronic phenomena January 30th, 2015

Everything You Need To Know About Nanopesticides January 30th, 2015

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Crystal light: New light-converting materials point to cheaper, more efficient solar power: University of Toronto engineers study first single crystal perovskites for new solar cell and LED applications January 30th, 2015

Possible Futures

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Nanotechnology in Energy Applications Market Research Report 2014-2018: Radiant Insights, Inc January 15th, 2015

'Mind the gap' between atomically thin materials December 23rd, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Academic/Education

Rice's Naomi Halas to direct Smalley Institute: Optics pioneer will lead Rice's multidisciplinary science institute January 15th, 2015

SUNY Board Appoints Dr. Alain Kaloyeros as Founding President of SUNY Polytechnic Institute January 13th, 2015

CNSE's Smart System Technology & Commercialization Center Successfully Recertifies as ISO 9001:2008 January 12th, 2015

SUNY Poly Now Accepting Applications to the Colleges of Nanoscale Science and Engineering for Fall 2015: Full Scholarships Available to Incoming CNSE Students January 7th, 2015

Nanotubes/Buckyballs

Chromium-centered cycloparaphenylene rings for making functionalized nanocarbons January 26th, 2015

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

Carbon nanotube finding could lead to flexible electronics with longer battery life January 14th, 2015

Nanomedicine

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Made-in-Singapore rapid test kit detects dengue antibodies from saliva: IBN's MedTech innovation simplifies diagnosis of infectious diseases January 29th, 2015

Iranian Researchers Planning to Produce Edible Insulin January 28th, 2015

Nanoparticles that deliver oligonucleotide drugs into cells described in Nucleic Acid Therapeutics January 28th, 2015

Announcements

Evidence mounts for quantum criticality theory: Findings bolster theory that quantum fluctuations drive strange electronic phenomena January 30th, 2015

Everything You Need To Know About Nanopesticides January 30th, 2015

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Crystal light: New light-converting materials point to cheaper, more efficient solar power: University of Toronto engineers study first single crystal perovskites for new solar cell and LED applications January 30th, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

2015 Nanonics Image Contest January 29th, 2015

OCSiAl supports NanoART Imagery Contest January 23rd, 2015

EnvisioNano: An image contest hosted by the National Nanotechnology Initiative (NNI) January 22nd, 2015

Laser-generated surface structures create extremely water-repellent metals: Super-hydrophobic properties could lead to applications in solar panels, sanitation and as rust-free metals January 20th, 2015

Nanobiotechnology

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Spider electro-combs its sticky nano-filaments January 28th, 2015

Nanoshuttle wear and tear: It's the mileage, not the age January 26th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE