Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Toning down cancer’s aggressiveness

Prof. Mansoor Amiji is working on research that would battle cancer by making tumor cells less aggressive. Photo by Lauren McFalls.
Prof. Mansoor Amiji is working on research that would battle cancer by making tumor cells less aggressive. Photo by Lauren McFalls.

Abstract:
The researchers are working on using nanoparticles, engineered for drug delivery, to reverse the tumor cell clusters' resistance to anti-cancer therapies.

Toning down cancer’s aggressiveness

Boston, MA | Posted on November 3rd, 2010

The fight against some cancers could depend on using nanotechnology to trick tumor cells into feeling well fed.

Mansoor Amiji, Distinguished Professor of Pharmaceutical Sciences at Northeastern University, believes tumor cells—like people—become more aggressive in pursuit of nourishment when they're "hungry." He theorizes that clusters of cancer cells deep within a tumor, where they receive limited oxygen and other nutrients, have higher stress levels and are more aggressive in fighting off chemotherapy.

Working from this theory, Amiji, who chairs the Department of Pharmaceutical Sciences in the School of Pharmacy within the Bouvé College of Health Sciences, will collaborate with researchers at Northeastern and Massachusetts General Hospital to explore innovative drug delivery and gene-silencing strategies to target these cancers. Assistant Professor of Chemical Engineering Rebecca Carrier and Matthews Distinguished University Professor of Chemistry and Chemical Biology Robert Hanson are Amiji's Northeastern collaborators.

The researchers are working on using nanoparticles, engineered for drug delivery, to reverse the tumor cell clusters' resistance to anti-cancer therapies. The nanoparticles would permeate the parts of tumors where the aggressive cells live, carrying RNA molecules that would block messages from disease-causing genes. Cutting off that communication would prevent the tumor cells from developing certain proteins that make them aggressive.

Amiji predicts suppressing their aggression—or "hunger"—could be a major breakthrough in treating highly aggressive ovarian and lung cancers.

"When living in this (hostile) environment, the threshold for killing tumor cells is much higher," Amiji said. "We want the threshold to be minimal so low doses of chemotherapy will kill those cells and make the treatment safer."

Relapse is common for ovarian and lung cancers, and drugs used in the first round of treatment often become ineffective in future treatments, Amiji explained. As a result, a doctor's primary recourse is to create cocktails of multiple drugs and increase the dosages. But Amiji hopes his new approach can replace this current treatment method.

Amiji's project, which advances Northeastern's leadership in use-inspired, interdisciplinary health research, is funded by a five-year, $2.32 million Cancer Nanotechnology Platform Partnership grant from the National Cancer Institute's (NCI) Alliance for Nanotechnology in Cancer program. Through this grant, Amiji and his team will also develop a library of target-specific nanoparticles they can screen and select from on a case-by-case basis when treating various forms of cancer.

Amiji pointed to Northeastern's tremendous momentum in nanotechnology research. The NCI recently designated Northeastern a Center of Cancer Nanotechnology Excellence with a $13.5 million award. Northeastern's Integrative Graduate Education and Research Traineeship (IGERT) nanomedicine program recently received a $3.1 million grant from the National Science Foundation to continue its success in educating the next generation of scientists and technologists in nanomedicine.

The University also signed an agreement in September with federal health researchers to advance research and guidance for occupational safety and health in nanotechnology.

"We have created a coherent nucleus of research and education in translational nanomedicine at Northeastern," Amiji said.

####

Contacts:
Greg St.Martin
617-373-5463

Copyright © Northeastern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Possible Futures

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Announcements

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Nanobiotechnology

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

Research partnerships

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project