Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Toning down cancer’s aggressiveness

Prof. Mansoor Amiji is working on research that would battle cancer by making tumor cells less aggressive. Photo by Lauren McFalls.
Prof. Mansoor Amiji is working on research that would battle cancer by making tumor cells less aggressive. Photo by Lauren McFalls.

Abstract:
The researchers are working on using nanoparticles, engineered for drug delivery, to reverse the tumor cell clusters' resistance to anti-cancer therapies.

Toning down cancer’s aggressiveness

Boston, MA | Posted on November 3rd, 2010

The fight against some cancers could depend on using nanotechnology to trick tumor cells into feeling well fed.

Mansoor Amiji, Distinguished Professor of Pharmaceutical Sciences at Northeastern University, believes tumor cells—like people—become more aggressive in pursuit of nourishment when they're "hungry." He theorizes that clusters of cancer cells deep within a tumor, where they receive limited oxygen and other nutrients, have higher stress levels and are more aggressive in fighting off chemotherapy.

Working from this theory, Amiji, who chairs the Department of Pharmaceutical Sciences in the School of Pharmacy within the Bouvé College of Health Sciences, will collaborate with researchers at Northeastern and Massachusetts General Hospital to explore innovative drug delivery and gene-silencing strategies to target these cancers. Assistant Professor of Chemical Engineering Rebecca Carrier and Matthews Distinguished University Professor of Chemistry and Chemical Biology Robert Hanson are Amiji's Northeastern collaborators.

The researchers are working on using nanoparticles, engineered for drug delivery, to reverse the tumor cell clusters' resistance to anti-cancer therapies. The nanoparticles would permeate the parts of tumors where the aggressive cells live, carrying RNA molecules that would block messages from disease-causing genes. Cutting off that communication would prevent the tumor cells from developing certain proteins that make them aggressive.

Amiji predicts suppressing their aggression—or "hunger"—could be a major breakthrough in treating highly aggressive ovarian and lung cancers.

"When living in this (hostile) environment, the threshold for killing tumor cells is much higher," Amiji said. "We want the threshold to be minimal so low doses of chemotherapy will kill those cells and make the treatment safer."

Relapse is common for ovarian and lung cancers, and drugs used in the first round of treatment often become ineffective in future treatments, Amiji explained. As a result, a doctor's primary recourse is to create cocktails of multiple drugs and increase the dosages. But Amiji hopes his new approach can replace this current treatment method.

Amiji's project, which advances Northeastern's leadership in use-inspired, interdisciplinary health research, is funded by a five-year, $2.32 million Cancer Nanotechnology Platform Partnership grant from the National Cancer Institute's (NCI) Alliance for Nanotechnology in Cancer program. Through this grant, Amiji and his team will also develop a library of target-specific nanoparticles they can screen and select from on a case-by-case basis when treating various forms of cancer.

Amiji pointed to Northeastern's tremendous momentum in nanotechnology research. The NCI recently designated Northeastern a Center of Cancer Nanotechnology Excellence with a $13.5 million award. Northeastern's Integrative Graduate Education and Research Traineeship (IGERT) nanomedicine program recently received a $3.1 million grant from the National Science Foundation to continue its success in educating the next generation of scientists and technologists in nanomedicine.

The University also signed an agreement in September with federal health researchers to advance research and guidance for occupational safety and health in nanotechnology.

"We have created a coherent nucleus of research and education in translational nanomedicine at Northeastern," Amiji said.

####

Contacts:
Greg St.Martin
617-373-5463

Copyright © Northeastern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Smaller, faster, cheaper: A new type of modulator for the future of data transmission July 27th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Industrial Nanotech, Inc. Provides Update on PCAOB Audited Financials July 27th, 2015

Possible Futures

Smaller, faster, cheaper: A new type of modulator for the future of data transmission July 27th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Global Corrosion Resistant Nano Coatings Market To 2015: Acute Market Reports July 27th, 2015

Global Zinc oxide nanopowders Industry 2015: Acute Market Reports July 25th, 2015

Academic/Education

Deben reports on the use of their CT500 in the X-ray microtomography laboratory at La Trobe University, Melbourne, Australia July 22nd, 2015

JPK reports on the use of SPM in the Messersmith Group at UC Berkeley looking at biologically inspired polymer adhesives. July 21st, 2015

Renishaw adds Raman analysis to Scanning Electron Microscopy at the University of Sydney, Australia July 9th, 2015

Oxford Instruments’ TritonXL Cryofree dilution refrigerator selected for the Oxford NQIT Quantum Technology Hub project June 30th, 2015

Nanomedicine

Stretching the limits on conducting wires July 25th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nanopaper as an optical sensing platform July 23rd, 2015

Albany College of Pharmacy and Health Sciences to Host One Week Symposium on Nanomedicine July 23rd, 2015

Announcements

Researchers predict material with record-setting melting point July 27th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Industrial Nanotech, Inc. Provides Update on PCAOB Audited Financials July 27th, 2015

Global Corrosion Resistant Nano Coatings Market To 2015: Acute Market Reports July 27th, 2015

Nanobiotechnology

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

Programming adult stem cells to treat muscular dystrophy and more by mimicking nature July 22nd, 2015

Biophotonics - Global Strategic Business Report 2015 July 21st, 2015

Rare form: Novel structures built from DNA emerge July 20th, 2015

Research partnerships

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

Stretching the limits on conducting wires July 25th, 2015

Ultra-thin hollow nanocages could reduce platinum use in fuel cell electrodes July 24th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project