Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Cosmeceutics company uses Malvern Zetasizer Nano to characterize environmentally

Abstract:
The rapid, real-time measurement capabilities of the Zetasizer Nano system from Malvern Instruments have enabled quantified nanoscale characterization of the environmental sensitivity of novel solubilization nanoparticles.

Cosmeceutics company uses Malvern Zetasizer Nano to characterize environmentally

Malvern, UK | Posted on October 28th, 2010

A joint research paper, presented at Particulate Systems Analysis 2008 [1] and a new publication in Cosmetics & Toiletries Sep 2010 [2], illustrate the application of dynamic light scattering (DLS) to investigate the effects of pH and temperature on the structure and particle size of environmentally-responsive Lipodisq® systems produced by Malvern Cosmeceutics Ltd, UK.

Lipodisqs are designed to mimic naturally occurring high-density lipoproteins which bind cholesterol for transport back to the liver for excretion. Composed of a phospholipid membrane core bound together into spherical or disc-like structures by a responsive chaperone molecule (a protein that assists non-covalent folding/unfolding), these particles can enclose and transport oil soluble molecules through an aqueous environment. Used to improve topical delivery of an active botanic or pharmaceutical ingredient, Lipodisqs can be engineered to withstand or respond to particular environmental specifications.

Using the Zetasizer Nano it was demonstrated that Poly(styrene-maleic acid) Lipodisq particles are sensitive to changes in pH, increasing in particle size from ~12nm to >200 nm over a pH range of 7.7 to 5.7. The temperature sensitivity of Poly(styrene-maleic acid) Lipodisq particles was also shown with an increase in particle size from ~20 nm to ~300 nm over a temperature range of 20°C to 90°C.

Both complexes were shown to spontaneously reassemble when these environmental changes were reversed.

Dynamic light scattering (DLS) is a particle sizing technique that delivers rapid, real-time data that are sensitive enough to demonstrate subtle changes over time for sizes below 1 nm. As such it is particularly suited to the investigation of environmentally triggered particle size changes in topical applications such as creams, gels and lotions.

References

[1] Harper, A., Kazsuba, M, Connah, M. & Tonge, S. pH and Temperature Responsive
Novel Nanoparticles Characterised by Dynamic Light Scattering Paper presented at
Particulate Systems Analysis 2008 (PSA 2008), Stratford-upon-Avon, UK. Sep 2008

[2] Harper et al, Environmentally responsive nanoparticles for delivery as
assessed via light scattering and infrared imaging, Cosmetics & Toiletries Vol
125, No 9, Sep 2010

Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern
Instruments Ltd

####

About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical distribution. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.

For more information, please click here

Contacts:
Trish Appleton
Kapler Communications
Knowledge Centre
Wyboston Lakes
Great North Road
Wyboston
Bedfordshire
MK44 3BY
UK
Tel: +44 (0)1480 479280
Fax: +44 (0)1480 470343

USA contact:

Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough
MA 01581-1042
USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403


Please send sales enquiries to:

Alison Vines
Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
Malvern
Worcestershire
WR14 1XZ
UK
Tel: +44 (0) 1684 892456
Fax: +44 (0) 1684 892789

Copyright © Malvern Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

A*STAR and industry form S$200M semiconductor R&D July 25th, 2014

Silicene Labs Announces the Launch of Patent-Pending, 2D Materials Composite Index™ : The Initial 2D Materials Composite Index™ for Q2 2014 Is: 857.3; Founders Include World-Renowned Physicist and Seasoned Business and IP Professionals July 24th, 2014

Iranian Scientists Produce Transparent Nanocomposite Coatings with Longer Lifetime July 24th, 2014

Nanomedicine

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

Researchers create vaccine for dust-mite allergies Main Page Content: Vaccine reduced lung inflammation to allergens in lab and animal tests July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

SentiMag® Now Available in Australia and New Zealand July 21st, 2014

Announcements

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

A*STAR and industry form S$200M semiconductor R&D July 25th, 2014

Silicene Labs Announces the Launch of Patent-Pending, 2D Materials Composite Index™ : The Initial 2D Materials Composite Index™ for Q2 2014 Is: 857.3; Founders Include World-Renowned Physicist and Seasoned Business and IP Professionals July 24th, 2014

Iranian Scientists Produce Transparent Nanocomposite Coatings with Longer Lifetime July 24th, 2014

Tools

Hysitron is Awarded TWO R&D 100 Awards for Highly Innovative Technology Developments in the Areas of Extreme Environments and Biological Mechanical Property Testing July 23rd, 2014

EPFL Research on the use of AFM based nanoscale IR spectroscopy for the study of single amyloid molecules wins poster competition at Swiss Physics Society meeting July 22nd, 2014

The Hiden EQP Plasma Diagnostic with on-board MCA July 22nd, 2014

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE