Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Nanodrug Enables Image-Guided Breast Cancer Therapy

Abstract:
By combining an iron oxide nanoparticle, a tumor-targeting peptide, and a therapeutic nucleic acid into one construct, a team of investigators from the Massachusetts General Hospital and Harvard Medical School have created an agent that holds potential as targeted therapy for breast cancer. In addition, this new agent can be easily tracked in the body using standard magnetic resonance imaging (MRI).

Nanodrug Enables Image-Guided Breast Cancer Therapy

Bethesda, MD | Posted on October 27th, 2010

Zdravka Medarova led this study. She and her colleagues published their results in the journal Cancer Research.

Dr. Medarova and her collaborators created their nanoparticle to bind to a tumor-specific molecules known as uMUC-1, which is found on the surface of over 90 percent of human breast tumors, and deliver a synthetic small interfering RNA (siRNA) molecule designed to shut down a specific gene - BIRC5 - that blocks cell death in most tumors and is associated with the development of drug resistance. The investigators also added a fluorescent dye to their nanoparticle to afford them the ability to track the nanoparticle using near-infrared spectroscopy. Because the nanoparticle itself is composed of superparamagnetic iron oxide, it is readily visible in MRI scans.

When added to breast cancer cells growing in culture, this nanoparticle construct had a profound impact on the expression of the BIRC5 gene, knocking down its expression. Both fluorescence imaging and MRI showed that the nanoparticle was taken up rapidly by the cells. Subsequent experiments showed that this construct had the same positive effect on both human pancreatic cancer cells and colon cancer cells.

Based on these initial results, the investigators injected the nanoparticles intravenously into mice bearing human breast tumors. The drug was administered on two separate occasions, a week apart. Both MRI and fluorescence imaging scans revealed that the nanoparticle accumulated preferentially in the tumors and that tumor levels remained high over the course of the two week experiment. Very little drug accumulated in muscle tissue surrounding the tumors.

When the tumors themselves were examined, the investigators found that the siRNA payload produced a five-fold increase in cell death compared to when animals were instead treated with a similar construct bearing a nonsense siRNA molecule even though the two nanoparticles accumulated to the same level in the tumors of treated animals. This result shows that the therapeutic effect of the construct is independent of its tumor targeting properties and is instead a result of its therapeutic siRNA payload.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "Image-Guided Breast Tumor Therapy Using a Small Interfering RNA Nanodrug." An abstract of this paper is available at the journal's website.

View abstract at dx.doi.org/doi:10.1158/0008-5472.CAN-10-2070

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

New flexible material can make any window 'smart' August 23rd, 2016

University of Puerto Rico and NASA back in the news – XEI reports August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Govt.-Legislation/Regulation/Funding/Policy

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

New flexible material can make any window 'smart' August 23rd, 2016

Researchers reduce expensive noble metals for fuel cell reactions August 22nd, 2016

Spider silk: Mother Nature's bio-superlens August 22nd, 2016

Possible Futures

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

New flexible material can make any window 'smart' August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Researchers reduce expensive noble metals for fuel cell reactions August 22nd, 2016

Academic/Education

Nanotech Security Featured by Simon Fraser University: Company's Anti-Counterfeiting Technology Developed With the Help of University's 4D LABS Materials Research Institute August 21st, 2016

W.M. Keck Foundation awards Cal State LA a $375,000 research and education grant August 4th, 2016

Thomas Swan and NGI announce unique partnership July 28th, 2016

The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Nanomedicine

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Curbing the life-long effects of traumatic brain injury August 19th, 2016

Lab team spins ginger into nanoparticles to heal inflammatory bowel disease August 19th, 2016

Announcements

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

New flexible material can make any window 'smart' August 23rd, 2016

University of Puerto Rico and NASA back in the news – XEI reports August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Nanobiotechnology

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Curbing the life-long effects of traumatic brain injury August 19th, 2016

Lab team spins ginger into nanoparticles to heal inflammatory bowel disease August 19th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic