Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanodrug Enables Image-Guided Breast Cancer Therapy

Abstract:
By combining an iron oxide nanoparticle, a tumor-targeting peptide, and a therapeutic nucleic acid into one construct, a team of investigators from the Massachusetts General Hospital and Harvard Medical School have created an agent that holds potential as targeted therapy for breast cancer. In addition, this new agent can be easily tracked in the body using standard magnetic resonance imaging (MRI).

Nanodrug Enables Image-Guided Breast Cancer Therapy

Bethesda, MD | Posted on October 27th, 2010

Zdravka Medarova led this study. She and her colleagues published their results in the journal Cancer Research.

Dr. Medarova and her collaborators created their nanoparticle to bind to a tumor-specific molecules known as uMUC-1, which is found on the surface of over 90 percent of human breast tumors, and deliver a synthetic small interfering RNA (siRNA) molecule designed to shut down a specific gene - BIRC5 - that blocks cell death in most tumors and is associated with the development of drug resistance. The investigators also added a fluorescent dye to their nanoparticle to afford them the ability to track the nanoparticle using near-infrared spectroscopy. Because the nanoparticle itself is composed of superparamagnetic iron oxide, it is readily visible in MRI scans.

When added to breast cancer cells growing in culture, this nanoparticle construct had a profound impact on the expression of the BIRC5 gene, knocking down its expression. Both fluorescence imaging and MRI showed that the nanoparticle was taken up rapidly by the cells. Subsequent experiments showed that this construct had the same positive effect on both human pancreatic cancer cells and colon cancer cells.

Based on these initial results, the investigators injected the nanoparticles intravenously into mice bearing human breast tumors. The drug was administered on two separate occasions, a week apart. Both MRI and fluorescence imaging scans revealed that the nanoparticle accumulated preferentially in the tumors and that tumor levels remained high over the course of the two week experiment. Very little drug accumulated in muscle tissue surrounding the tumors.

When the tumors themselves were examined, the investigators found that the siRNA payload produced a five-fold increase in cell death compared to when animals were instead treated with a similar construct bearing a nonsense siRNA molecule even though the two nanoparticles accumulated to the same level in the tumors of treated animals. This result shows that the therapeutic effect of the construct is independent of its tumor targeting properties and is instead a result of its therapeutic siRNA payload.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "Image-Guided Breast Tumor Therapy Using a Small Interfering RNA Nanodrug." An abstract of this paper is available at the journal's website.

View abstract at dx.doi.org/doi:10.1158/0008-5472.CAN-10-2070

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

Govt.-Legislation/Regulation/Funding/Policy

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Possible Futures

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Academic/Education

The Institute of Applied Physics at the University of Tsukuba near Tokyo in Japan uses Deben's ARM2 detector to better understand catalytic reaction mechanisms June 27th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

SUNY Poly Professor Eric Lifshin Selected for ‘Fellow of the Microanalysis Society’ Position for Significant Contributions to Microanalysis June 13th, 2018

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Nanomedicine

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Announcements

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

Nanobiotechnology

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Arrowhead Presents New Clinical Data on ARO-AAT at Alpha-1 National Education Conference July 1st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project