Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticles Deliver Combination Chemotherapy Directly to Prostate Cancer Cells

Abstract:
In recent years, studies have shown that for many types of cancer, combination drug therapy is more effective than single drugs. However, it is usually difficult to get the right amount of each drug to the tumor. Now, researchers at the Massachusetts Institute of Technology (MIT) and Brigham and Women's Hospital have developed a nanoparticle that can deliver precise doses of two or more drugs to prostate cancer cells. Such particles, say the researchers, could improve the effectiveness of chemotherapy while minimizing the side effects normally seen with these drugs.

Nanoparticles Deliver Combination Chemotherapy Directly to Prostate Cancer Cells

Bethesda, MD | Posted on October 27th, 2010

In a study appearing in the Proceedings of the National Academy of Sciences, a team of investigators led by Omid Farokhzad and Robert Langer, both members of the MIT-Harvard Center for Cancer Nanotechnology Excellence, demonstrated the utility of their new particle by using it to deliver cisplatin and docetaxel, two drugs commonly used to treat many different types of cancer.

To build their nanoparticles, the researchers developed a new strategy that allowed them to incorporate drugs with very different physical properties, which had been impossible with previous drug-delivering nanoparticles. In earlier generations of nanoparticles, drug molecules were encapsulated in a polymer coating. Using those particles, hydrophobic (water-repelling) drugs, such as docetaxel, and hydrophilic (water-attracting) drugs, such as cisplatin, can't be carried together, nor can drugs with different charges. "With the old way, you can only do it if the two drugs are physically and chemically similar," said Dr. Farokhzad. "With this way, you can put in drugs that are relatively different from each other."

With the researchers' new technique, called "drug-polymer blending," drug molecules are hung like pendants from individual units of the polymer before the units are assembled into a polymer nanoparticle. This approach allows the researchers to precisely control the ratio of drugs loaded into the particle and to control the rate at which each drug will be released once it enters a tumor cell.

For this study, once the investigators loaded the drugs into the nanoparticle, the researchers added a tag that binds to a molecule called PSMA that is located on the surfaces of most prostate tumor cells. This tag allows the nanoparticles to go directly to their target, bypassing healthy tissues and potentially reducing the side effects caused by most chemotherapy drugs.

The researchers have filed for a patent on the polymer-blending fabrication technique and are now testing the drug-delivering particles in animals. Once they gather enough animal data, which could take a few years, they hope to begin clinical trials.

This work, which is detailed in a paper titled, "Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy," was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's website.

View abstract at www.pnas.org/content/107/42/17939

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

Possible Futures

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Self Assembly

Self-assembling particles brighten future of LED lighting January 18th, 2017

Manchester scientists tie the tightest knot ever achieved January 13th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Researchers fabricate high performance Cu(OH)2 supercapacitor electrodes December 29th, 2016

Nanomedicine

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Announcements

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

A big nano boost for solar cells: Kyoto University and Osaka Gas effort doubles current efficiencies January 21st, 2017

Nanobiotechnology

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project