Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Rice, TMC team take aim at pancreatic cancer

Abstract:
National Cancer Institute funds preclinical 'theranostic' study

Rice, TMC team take aim at pancreatic cancer

Houston, TX | Posted on October 18th, 2010

Researchers from Rice University's Laboratory for Nanophotonics (LANP), the radiology department at Baylor College of Medicine (BCM) and the University of Texas MD Anderson Cancer Center are preparing to test a combined approach for diagnosing and treating pancreatic cancer with a specially engineered nanoparticle.

The five-year, preclinical testing program will be funded by a newly announced $1.8 million grant from the National Cancer Institute's (NCI) Alliance for Nanotechnology in Cancer program.

"Pancreatic cancer is notoriously difficult to treat, and we hope nanoparticle-based 'theranostics' can change that," said LANP Director Naomi Halas, Rice's Stanley C. Moore Professor in Electrical and Computer Engineering and professor of chemistry and biomedical engineering. "Our nanoparticles are designed to specifically target cancer cells and to function as both diagnostic and therapeutic agents."

Pancreatic cancer is one of the most deadly forms of cancer. Surgery is often the only treatment option, and the five-year, postsurgical survival rate is less than 25 percent.

Halas is the inventor of gold nanoshells, tiny gold-sheathed particles that can harvest light and convert it to heat. She also helped pioneer the use of nanoshells for cancer treatment, and she is the principal investigator on the new NCI grant. The theranostic project team includes co-principal investigators Amit Joshi, assistant professor of radiology at BCM; Sunil Krishnan, associate professor in radiation oncology at MD Anderson; and Peter Nordlander, professor of physics and astronomy at Rice.

Theranostics involve technologies and agents that can diagnose and treat diseases in a single procedure. The theranostic particle that will be tested at Rice, BCM and MD Anderson was invented at LANP.

"A seamless integration of multiple imaging and therapeutic technologies within a single nanoparticle is required to tackle diseases like pancreatic cancer, which often resist conventional therapies," Joshi said.

At the heart of the particle is a nanoshell that can be used to kill cancer cells with heat. The particle can also be tagged with antibodies that allow it to home in on specific types of cancer cells. In addition, the nanoparticle is designed to provide high-resolution images regarding its location in the body and in the tumor. This is accomplished by combining an FDA-cleared dye for fluorescence imaging with an active marker for MRI imaging. These combined capabilities allow researchers to track the nanoparticles throughout the body and even observe their distribution within the tumor before, during and after treatment.

"This level of highly detailed information on nanoparticle location in the body has not been obtainable previously," Halas said.

In the first published tests of the new particle last year, Joshi, Halas and colleagues showed it could be used to simultaneously detect and destroy breast and ovarian cancer cells in cell cultures.

In the NCI study, researchers will test whether the particles can be used to image and treat pancreatic cancer in mice. The tests will investigate how well the particles work as imaging agents -- both in MRI scans and in fluorescent optical scans, how well they target specific cell types, where they go inside the body after testing and treatment and how well they perform as therapeutic agents. In addition, Krishnan's lab at MD Anderson has a particular interest in testing the particles to see if they can be used to boost the effectiveness of radiation therapy.

"Nanoparticle-based theranostics holds great promise, not only for treating pancreatic cancer, but for treating other forms of cancer as well," Halas said. "But successfully translating new technology like this from the lab to the clinic requires excellent research partnerships, like those we have at Baylor College of Medicine and MD Anderson."

The Laboratory for Nanophotonics at Rice was formed in 2004 with the mission to invent, understand, develop, simulate, control, optimize and apply nanoscale optical elements, components and systems. LANP features a strong interdisciplinary research program in three primary areas: metal-based plasmonics, nanoparticle-enhanced sensing and spectroscopy, and nanophotonic applications in biomedicine.

####

For more information, please click here

Contacts:
David Ruth
713-348-6327


Jade Boyd
713-348-6778

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Searching for a nanotech self-organizing principle May 1st, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Academic/Education

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

The Ottawa Hospital Research Institute uses the ZetaView from Particle Metrix to study membrane microparticles as potential biomarkers for underlying diseases April 12th, 2016

FEI Partners with Five Pharmaceutical Companies, the Medical Research Council and the University of Cambridge to form Cryo-EM Research Consortium April 5th, 2016

SUNY Poly, in Collaboration with the George Washington School of Medicine and Health Sciences and Stony Brook University, Demonstrates Pioneering Method to Visualize and Identify Engineered Nanoparticles in Tissue March 25th, 2016

Nanomedicine

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Nanoparticles hold promise as double-edged sword against genital herpes April 28th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Announcements

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Brookhaven's Oleg Gang Named a Battelle 'Inventor of the Year': Recognized for work using DNA to guide and regulate the self-assembly of nanoparticles into clusters and arrays with controllable properties April 25th, 2016

Zip software can detect the quantum-classical boundary: Compression of experimental data reveals the presence of quantum correlations April 21st, 2016

Making electronics out of coal: Instead of burning up this complex hydrocarbon, let's make devices from it April 20th, 2016

Nano-magnets produce 3-dimensional images: Wide-view 3-dimensional holographic display composed of nano-magnetic pixels April 20th, 2016

Nanobiotechnology

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Nanoparticles hold promise as double-edged sword against genital herpes April 28th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Research partnerships

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

Nanoparticles hold promise as double-edged sword against genital herpes April 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic