Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Rice, TMC team take aim at pancreatic cancer

Abstract:
National Cancer Institute funds preclinical 'theranostic' study

Rice, TMC team take aim at pancreatic cancer

Houston, TX | Posted on October 18th, 2010

Researchers from Rice University's Laboratory for Nanophotonics (LANP), the radiology department at Baylor College of Medicine (BCM) and the University of Texas MD Anderson Cancer Center are preparing to test a combined approach for diagnosing and treating pancreatic cancer with a specially engineered nanoparticle.

The five-year, preclinical testing program will be funded by a newly announced $1.8 million grant from the National Cancer Institute's (NCI) Alliance for Nanotechnology in Cancer program.

"Pancreatic cancer is notoriously difficult to treat, and we hope nanoparticle-based 'theranostics' can change that," said LANP Director Naomi Halas, Rice's Stanley C. Moore Professor in Electrical and Computer Engineering and professor of chemistry and biomedical engineering. "Our nanoparticles are designed to specifically target cancer cells and to function as both diagnostic and therapeutic agents."

Pancreatic cancer is one of the most deadly forms of cancer. Surgery is often the only treatment option, and the five-year, postsurgical survival rate is less than 25 percent.

Halas is the inventor of gold nanoshells, tiny gold-sheathed particles that can harvest light and convert it to heat. She also helped pioneer the use of nanoshells for cancer treatment, and she is the principal investigator on the new NCI grant. The theranostic project team includes co-principal investigators Amit Joshi, assistant professor of radiology at BCM; Sunil Krishnan, associate professor in radiation oncology at MD Anderson; and Peter Nordlander, professor of physics and astronomy at Rice.

Theranostics involve technologies and agents that can diagnose and treat diseases in a single procedure. The theranostic particle that will be tested at Rice, BCM and MD Anderson was invented at LANP.

"A seamless integration of multiple imaging and therapeutic technologies within a single nanoparticle is required to tackle diseases like pancreatic cancer, which often resist conventional therapies," Joshi said.

At the heart of the particle is a nanoshell that can be used to kill cancer cells with heat. The particle can also be tagged with antibodies that allow it to home in on specific types of cancer cells. In addition, the nanoparticle is designed to provide high-resolution images regarding its location in the body and in the tumor. This is accomplished by combining an FDA-cleared dye for fluorescence imaging with an active marker for MRI imaging. These combined capabilities allow researchers to track the nanoparticles throughout the body and even observe their distribution within the tumor before, during and after treatment.

"This level of highly detailed information on nanoparticle location in the body has not been obtainable previously," Halas said.

In the first published tests of the new particle last year, Joshi, Halas and colleagues showed it could be used to simultaneously detect and destroy breast and ovarian cancer cells in cell cultures.

In the NCI study, researchers will test whether the particles can be used to image and treat pancreatic cancer in mice. The tests will investigate how well the particles work as imaging agents -- both in MRI scans and in fluorescent optical scans, how well they target specific cell types, where they go inside the body after testing and treatment and how well they perform as therapeutic agents. In addition, Krishnan's lab at MD Anderson has a particular interest in testing the particles to see if they can be used to boost the effectiveness of radiation therapy.

"Nanoparticle-based theranostics holds great promise, not only for treating pancreatic cancer, but for treating other forms of cancer as well," Halas said. "But successfully translating new technology like this from the lab to the clinic requires excellent research partnerships, like those we have at Baylor College of Medicine and MD Anderson."

The Laboratory for Nanophotonics at Rice was formed in 2004 with the mission to invent, understand, develop, simulate, control, optimize and apply nanoscale optical elements, components and systems. LANP features a strong interdisciplinary research program in three primary areas: metal-based plasmonics, nanoparticle-enhanced sensing and spectroscopy, and nanophotonic applications in biomedicine.

####

For more information, please click here

Contacts:
David Ruth
713-348-6327


Jade Boyd
713-348-6778

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Solving molybdenum disulfide's 'thin' problem: Research team increases material's light emission by twelve times March 29th, 2015

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Academic/Education

LAMDAMAP 2015 hosted by the University March 26th, 2015

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

SUNY POLY CNSE to Host First Ever Northeast Semi Supply Conference (NESCO) Conference Will Connect New and Emerging Innovators in the Northeastern US and Canada with Industry Leaders and Strategic Investors to Discuss Future Growth Opportunities in NYS March 25th, 2015

FEI Joins University of Ulm and CEOS on SALVE Project Research Collaboration: The Sub-Ångström Low Voltage Electron (SALVE) microscope should improve contrast and reduce damage on bio-molecules and two-dimensional nanomaterials, such as graphene March 18th, 2015

Nanomedicine

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Graphene reduces wear of alumina ceramic March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Nanorobotic agents open the blood-brain barrier, offering hope for new brain treatments March 25th, 2015

Announcements

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Solving molybdenum disulfide's 'thin' problem: Research team increases material's light emission by twelve times March 29th, 2015

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

FEI Technology Award of the German Neuroscience Society Goes to Benjamin Judkewitz of the University of Berlin: Bi-annual award honors excellence in brain research during the German Neuroscience Society’s Annual Meeting, held 18-21 March 2015 March 26th, 2015

FEI Announces Image Contest Grand Prize Winner: Francisco Rangel of the National Institute of Technology, INT/MCTI, Brazil, wins the contest with his “Expanded Vermiculite” image March 23rd, 2015

Halas, Nordlander awarded Optical Society's R.W. Wood Prize: Rice University researchers recognized for pioneering nanophotonics March 21st, 2015

Hiden Instruments identified in London Stock Exchange’s ‘1000 Companies to Inspire Britain' March 21st, 2015

Nanobiotechnology

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Dolomite’s microfluidics technology ideal for B cell encapsulation March 24th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

TGAC's take on the first portable DNA sequencing 'laboratory': First remote laboratory allows researchers to conduct real-time anaylsis March 19th, 2015

Research partnerships

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

ORNL-led team demonstrates desalination with nanoporous graphene membrane March 25th, 2015

New kind of 'tandem' solar cell developed: Researchers combine 2 types of photovoltaic material to make a cell that harnesses more sunlight March 24th, 2015

UW scientists build a nanolaser using a single atomic sheet March 24th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE