Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Advanced imaging for bone research and materials science

Schematic of the new nano-CT method. The sample is scanned with an X-ray beam while the detector records a diffraction pattern for every beam position. The sample is then turned around its axis and scanned again, until a complete set of data is gathered for every angle. A high-resolution three-dimensional image of the sample is then computed from the hundreds of thousands of diffraction patterns by means of specially developed image reconstruction algorithms.
Schematic of the new nano-CT method. The sample is scanned with an X-ray beam while the detector records a diffraction pattern for every beam position. The sample is then turned around its axis and scanned again, until a complete set of data is gathered for every angle. A high-resolution three-dimensional image of the sample is then computed from the hundreds of thousands of diffraction patterns by means of specially developed image reconstruction algorithms.

Abstract:
High-resolution method for computed nano-tomography developed

Advanced imaging for bone research and materials science

Germany | Posted on October 12th, 2010

A novel nano-tomography method developed by a team of researchers from the Technische Universität München (TUM), the Paul Scherrer Institute (PSI) and the ETH Zurich opens the door to computed tomography examinations of minute structures at nanometer resolutions. The new method makes possible, for example, three-dimensional internal imaging of fragile bone structures. The first nano-CT images generated with this procedure will be published in the renowned journal Nature on September 23, 2010. This new technique will facilitate advances in both life sciences and materials sciences.

Osteoporosis, a medical condition in which bones become brittle and fragile from a loss of density, is among the most common diseases in aging bones: In Germany around a quarter of the population aged over 50 is affected. Patients' bone material shrinks rapidly, leading to a significantly increased risk of fracture. In clinical research to date, osteoporosis is diagnosed almost exclusively by establishing an overall reduction in bone density. This approach, however, gives little information about the associated, and equally important, local structure and bone density changes. Franz Pfeiffer, TUM professor for Biomedical Physics and head of the research team, has resolved the dilemma: "With our newly developed nano-CT method it is now possible to visualize the bone structure and density changes at high resolutions and in 3D. This enables us to do research on structural changes related to osteoporosis on a nanoscale and thus develop better therapeutic approaches."

During development, Pfeiffer's team built on X-ray computed tomography (CT). The principle is well established - CT scanners are used every day in hospitals and medical practices for the diagnostic screening of the human body. In the process the human body is X-rayed while a detector records from different angles how much radiation is being absorbed. In principle it is nothing more than taking multiple X-ray pictures from various directions. A number of such pictures are then used to generate digital 3D images of the body's interior using image processing.

The newly developed method measures not only the overall beam intensity absorbed by the object under examination at each angle, but also those parts of the X-ray beam that are deflected in different directions - "diffracted" in the language of physics. Such a diffraction pattern is generated for every point in the sample. This supplies additional information about the exact nanostructure, as X-ray radiation is particularly sensitive to the tiniest of structural changes. "Because we have to take and process so many individual pictures with extreme precision, it was particularly important during the implementation of the method to use high-brilliance X-ray radiation and fast, low-noise pixel detectors - both available at the Swiss Light Source (SLS)," says Oliver Bunk, who was responsible for the requisite experimental setup at the PSI synchrotron facilities in Switzerland.

The diffraction patterns are then processed using an algorithm developed by the team. TUM researcher Martin Dierolf, lead author of the Nature article, explains: "We developed an image reconstruction algorithm that generates a high-resolution, three-dimensional image of the sample using over one hundred thousand diffraction patterns. This algorithm takes into account not only classical X-ray absorption, but also the significantly more sensitive phase shift of the X-rays." A showcase example of the new technique was the examination of a 25-micrometer, superfine bone specimen of a laboratory mouse - with surprisingly exact results. The so-called phase contrast CT pictures show even smallest variations in the specimen's bone density with extremely high precision: Cross-sections of cavities where bone cells reside and their roughly 100 nanometer-fine interconnection network are clearly visible.

"Although the new nano-CT procedure does not achieve the spatial resolution currently available in electron microscopy, it can - because of the high penetration of X-rays - generate three-dimensional tomography images of bone samples," comments Roger Wepf, director of the Electron Microscopy Center of the ETH Zurich (EMEZ). "Furthermore, the new nano-CT procedure stands out with its high precision bone density measurement capacity, which is particularly important in bone research." This method will open the door to more precise studies on the early phase of osteoporosis, in particular, and evaluation of the therapeutic outcomes of various treatments in clinical studies.

The new technique is also very interesting for non-medical applications: Further fields of application include the development of new materials in materials science or in the characterization of semiconductor components. Ultimately, the nano-CT procedure may also be transferred to novel, laser-based X-ray sources, such as the ones currently under development at the Cluster of Excellence "Munich-Centre for Advanced Photonics" (MAP) and at the recently approved large-scale research project "Centre for Advanced Laser Applications" (CALA) on the TUM-Campus Garching near Munich.

Original publication:

Martin Dierolf, Andreas Menzel, Pierre Thibault, Philipp Schneider, Cameron M. Kewish, Roger Wepf, Oliver Bunk, Franz Pfeiffer: "Ptychographic X-Ray Computed Tomography at the Nano-Scale". Nature, 467, 436-439, 23. September 2010 - DOI: 10.1038/nature09419

####

For more information, please click here

Contacts:
Prof. Franz Pfeiffer
Chair of Biomedical Physics Technische Universität München
James-Franck-Straße 1 85748 Garching, Germany
Tel.: +49 89 289 12551
Fax: +49 89 289 12548

Dr. Oliver Bunk
Laboratory for Macromolecules and Bioimaging
Paul Scherrer Institute
3232 Villigen PSI, Switzerland
Tel.: +41 56 310 3077

Dr. Roger Albert Wepf
EMEZ – Electron Microscopy ETH Zurich
ETH Zurich
Wolfgang-Pauli-Str. 16 8093 Zurich, Switzerland
Tel: +41 44 633 45 58

Copyright © Technische Universitaet Muenchen

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Unconventional superconductor may be used to create quantum computers of the future: They have probably succeeded in creating a topological superconductor February 19th, 2018

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

European & Korean Project To Demo World’s First 5G Platform During Winter Games February 15th, 2018

Physics

Liquid crystal molecules form nano rings: Quantized self-assembly enables design of materials with novel properties February 7th, 2018

New exotic phenomena seen in photonic crystals: Researchers observe, for the first time, topological effects unique to an “open” system January 12th, 2018

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure: Researchers are the first to observe the electronic structure of graphene in an engineered semiconductor; finding could lead to progress in advanced optoelectronics and data processing December 13th, 2017

Leti Develops World’s First Micro-Coolers for CERN Particle Detectors: Leti Design, Fabrication and Packaging Expertise Extends to Very Large Scientific Instruments December 11th, 2017

Possible Futures

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers February 15th, 2018

Rutgers-Led Innovation Could Spur Faster, Cheaper, Nano-Based Manufacturing: Scalable and cost-effective manufacturing of thin film devices February 14th, 2018

Academic/Education

Luleå University of Technology is using the Deben CT5000TEC stage to perform x-ray microtomography experiments with the ZEISS Xradia 510 Versa to understand deformation and strain inside inhomogeneous materials November 7th, 2017

Park Systems Announces the Grand Opening of the Park NanoScience Center at SUNY Polytechnic Institute November 3rd, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Moving at the Speed of Light: University of Arizona selected for high-impact, industrial demonstration of new integrated photonic cryogenic datalink for focal plane arrays: Program is major milestone for AIM Photonics August 10th, 2017

Nanomedicine

Arrowhead Receives Regulatory Clearance to Begin Phase 1/2 Study of ARO-HBV for Treatment of Hepatitis B February 15th, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers February 15th, 2018

Understanding brain functions using upconversion nanoparticles: Researchers can now send light deep into the brain to study neural activities February 14th, 2018

Materials/Metamaterials

Rutgers-Led Innovation Could Spur Faster, Cheaper, Nano-Based Manufacturing: Scalable and cost-effective manufacturing of thin film devices February 14th, 2018

Graphene on toast, anyone? Rice University scientists create patterned graphene onto food, paper, cloth, cardboard February 13th, 2018

Atomic Flaws Create Surprising, High-Efficiency UV LED Materials: Subtle surface defects increase UV light emission in greener, more cost-effective LED and catalyst materials February 8th, 2018

A new radiation detector made from graphene: A new bolometer exploits the thermoelectric properties of graphene February 6th, 2018

Announcements

Computers aid discovery of new, inexpensive material to make LEDs with high color quality February 20th, 2018

Unconventional superconductor may be used to create quantum computers of the future: They have probably succeeded in creating a topological superconductor February 19th, 2018

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

European & Korean Project To Demo World’s First 5G Platform During Winter Games February 15th, 2018

Tools

New method enables high-resolution measurements of magnetism February 7th, 2018

Nanometrics Selected for Fab-Wide Process Control Metrology by Domestic China 3D-NAND Manufacturer: Latest Fab Win Includes Comprehensive Suite for Substrate, Thin Film and Critical Dimension Metrology February 7th, 2018

A new radiation detector made from graphene: A new bolometer exploits the thermoelectric properties of graphene February 6th, 2018

Measuring the temperature of two-dimensional materials at the atomic level February 3rd, 2018

Nanobiotechnology

Arrowhead Receives Regulatory Clearance to Begin Phase 1/2 Study of ARO-HBV for Treatment of Hepatitis B February 15th, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers February 15th, 2018

Understanding brain functions using upconversion nanoparticles: Researchers can now send light deep into the brain to study neural activities February 14th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project