Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Advanced imaging for bone research and materials science

Schematic of the new nano-CT method. The sample is scanned with an X-ray beam while the detector records a diffraction pattern for every beam position. The sample is then turned around its axis and scanned again, until a complete set of data is gathered for every angle. A high-resolution three-dimensional image of the sample is then computed from the hundreds of thousands of diffraction patterns by means of specially developed image reconstruction algorithms.
Schematic of the new nano-CT method. The sample is scanned with an X-ray beam while the detector records a diffraction pattern for every beam position. The sample is then turned around its axis and scanned again, until a complete set of data is gathered for every angle. A high-resolution three-dimensional image of the sample is then computed from the hundreds of thousands of diffraction patterns by means of specially developed image reconstruction algorithms.

Abstract:
High-resolution method for computed nano-tomography developed

Advanced imaging for bone research and materials science

Germany | Posted on October 12th, 2010

A novel nano-tomography method developed by a team of researchers from the Technische Universität München (TUM), the Paul Scherrer Institute (PSI) and the ETH Zurich opens the door to computed tomography examinations of minute structures at nanometer resolutions. The new method makes possible, for example, three-dimensional internal imaging of fragile bone structures. The first nano-CT images generated with this procedure will be published in the renowned journal Nature on September 23, 2010. This new technique will facilitate advances in both life sciences and materials sciences.

Osteoporosis, a medical condition in which bones become brittle and fragile from a loss of density, is among the most common diseases in aging bones: In Germany around a quarter of the population aged over 50 is affected. Patients' bone material shrinks rapidly, leading to a significantly increased risk of fracture. In clinical research to date, osteoporosis is diagnosed almost exclusively by establishing an overall reduction in bone density. This approach, however, gives little information about the associated, and equally important, local structure and bone density changes. Franz Pfeiffer, TUM professor for Biomedical Physics and head of the research team, has resolved the dilemma: "With our newly developed nano-CT method it is now possible to visualize the bone structure and density changes at high resolutions and in 3D. This enables us to do research on structural changes related to osteoporosis on a nanoscale and thus develop better therapeutic approaches."

During development, Pfeiffer's team built on X-ray computed tomography (CT). The principle is well established - CT scanners are used every day in hospitals and medical practices for the diagnostic screening of the human body. In the process the human body is X-rayed while a detector records from different angles how much radiation is being absorbed. In principle it is nothing more than taking multiple X-ray pictures from various directions. A number of such pictures are then used to generate digital 3D images of the body's interior using image processing.

The newly developed method measures not only the overall beam intensity absorbed by the object under examination at each angle, but also those parts of the X-ray beam that are deflected in different directions - "diffracted" in the language of physics. Such a diffraction pattern is generated for every point in the sample. This supplies additional information about the exact nanostructure, as X-ray radiation is particularly sensitive to the tiniest of structural changes. "Because we have to take and process so many individual pictures with extreme precision, it was particularly important during the implementation of the method to use high-brilliance X-ray radiation and fast, low-noise pixel detectors - both available at the Swiss Light Source (SLS)," says Oliver Bunk, who was responsible for the requisite experimental setup at the PSI synchrotron facilities in Switzerland.

The diffraction patterns are then processed using an algorithm developed by the team. TUM researcher Martin Dierolf, lead author of the Nature article, explains: "We developed an image reconstruction algorithm that generates a high-resolution, three-dimensional image of the sample using over one hundred thousand diffraction patterns. This algorithm takes into account not only classical X-ray absorption, but also the significantly more sensitive phase shift of the X-rays." A showcase example of the new technique was the examination of a 25-micrometer, superfine bone specimen of a laboratory mouse - with surprisingly exact results. The so-called phase contrast CT pictures show even smallest variations in the specimen's bone density with extremely high precision: Cross-sections of cavities where bone cells reside and their roughly 100 nanometer-fine interconnection network are clearly visible.

"Although the new nano-CT procedure does not achieve the spatial resolution currently available in electron microscopy, it can - because of the high penetration of X-rays - generate three-dimensional tomography images of bone samples," comments Roger Wepf, director of the Electron Microscopy Center of the ETH Zurich (EMEZ). "Furthermore, the new nano-CT procedure stands out with its high precision bone density measurement capacity, which is particularly important in bone research." This method will open the door to more precise studies on the early phase of osteoporosis, in particular, and evaluation of the therapeutic outcomes of various treatments in clinical studies.

The new technique is also very interesting for non-medical applications: Further fields of application include the development of new materials in materials science or in the characterization of semiconductor components. Ultimately, the nano-CT procedure may also be transferred to novel, laser-based X-ray sources, such as the ones currently under development at the Cluster of Excellence "Munich-Centre for Advanced Photonics" (MAP) and at the recently approved large-scale research project "Centre for Advanced Laser Applications" (CALA) on the TUM-Campus Garching near Munich.

Original publication:

Martin Dierolf, Andreas Menzel, Pierre Thibault, Philipp Schneider, Cameron M. Kewish, Roger Wepf, Oliver Bunk, Franz Pfeiffer: "Ptychographic X-Ray Computed Tomography at the Nano-Scale". Nature, 467, 436-439, 23. September 2010 - DOI: 10.1038/nature09419

####

For more information, please click here

Contacts:
Prof. Franz Pfeiffer
Chair of Biomedical Physics Technische Universität München
James-Franck-Straße 1 85748 Garching, Germany
Tel.: +49 89 289 12551
Fax: +49 89 289 12548

Dr. Oliver Bunk
Laboratory for Macromolecules and Bioimaging
Paul Scherrer Institute
3232 Villigen PSI, Switzerland
Tel.: +41 56 310 3077

Dr. Roger Albert Wepf
EMEZ – Electron Microscopy ETH Zurich
ETH Zurich
Wolfgang-Pauli-Str. 16 8093 Zurich, Switzerland
Tel: +41 44 633 45 58

Copyright © Technische Universitaet Muenchen

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Physics

Researchers find the 'key' to quantum network solution May 25th, 2015

News and information

Researchers find the 'key' to quantum network solution May 25th, 2015

One step closer to a single-molecule device: Columbia Engineering researchers first to create a single-molecule diode -- the ultimate in miniaturization for electronic devices -- with potential for real-world applications May 25th, 2015

DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles: Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015

Engineering Phase Changes in Nanoparticle Arrays: Scientists alter attractive and repulsive forces between DNA-linked particles to make dynamic, phase-shifting forms of nanomaterials May 25th, 2015

Possible Futures

Simulations predict flat liquid May 21st, 2015

Nature inspires first artificial molecular pump: Simple design mimics pumping mechanism of life-sustaining proteins found in living cells May 19th, 2015

NNCO and Museum of Science Fiction to Collaborate on Nanotechnology and 3D Printing Panels at Awesome Con May 19th, 2015

Quantum 'gruyères' for spintronics of the future: Topological insulators become a little less 'elusive' May 12th, 2015

Academic/Education

SUNY Poly CNSE and NIOSH Launch Federal Nano Health and Safety Consortium: May 20th, 2015

New JEOL E-Beam Lithography System to Enhance Quantum NanoFab Capabilities May 6th, 2015

FEI Partners With the George Washington University to Equip New Science & Engineering Hall: Suite of new high-performance microscopes will be used for cutting-edge experiments at GW’s new research facility April 29th, 2015

Renishaw Raman systems used to study 2D materials at Boston University, Massachusetts, USA. April 28th, 2015

Nanomedicine

DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles: Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015

Nanostructures Increase Corrosion Resistance in Metallic Body Implants May 24th, 2015

Iranian Scientists Use Magnetic Field to Transfer Anticancer Drug to Tumor Tissue May 24th, 2015

New Antibacterial Wound Dressing in Iran Can Display Replacement Time May 22nd, 2015

Materials/Metamaterials

DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles: Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015

Engineering Phase Changes in Nanoparticle Arrays: Scientists alter attractive and repulsive forces between DNA-linked particles to make dynamic, phase-shifting forms of nanomaterials May 25th, 2015

Nanostructures Increase Corrosion Resistance in Metallic Body Implants May 24th, 2015

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

Announcements

Researchers find the 'key' to quantum network solution May 25th, 2015

One step closer to a single-molecule device: Columbia Engineering researchers first to create a single-molecule diode -- the ultimate in miniaturization for electronic devices -- with potential for real-world applications May 25th, 2015

DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles: Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015

Engineering Phase Changes in Nanoparticle Arrays: Scientists alter attractive and repulsive forces between DNA-linked particles to make dynamic, phase-shifting forms of nanomaterials May 25th, 2015

Tools

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

Nanometrics Announces Live Webcast of Upcoming Investor and Analyst Day May 20th, 2015

Taking control of light emission: Researchers find a way of tuning light waves by pairing 2 exotic 2-D materials May 20th, 2015

DELMIC announces a workshop hosted by Phenom World on Integrated CLEM to be held on Wednesday June 24th at the Francis Crick Institute (Lincoln Inn Fields Laboratory). May 19th, 2015

Nanobiotechnology

DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles: Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015

Engineering Phase Changes in Nanoparticle Arrays: Scientists alter attractive and repulsive forces between DNA-linked particles to make dynamic, phase-shifting forms of nanomaterials May 25th, 2015

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

Supercomputer unlocks secrets of plant cells to pave the way for more resilient crops: IBM partners with University of Melbourne and UQ May 21st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project