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Nanofabrication facility includes bio-suites to support UCLA medical research
By Mike Rodewald & Jennifer Marcus
The California NanoSystems Institute at UCLA has opened its new Integrated Systems Nanofabrication Cleanroom (ISNC), more than doubling the amount of cleanroom space available on the Westwood campus and extending research capabilities to researchers in biology and medicine.
The facility, which houses more than $8 million of state-of-the-art equipment, features 9,700 square feet of highly purified and regulated cleanroom and support space, kept free of bacteria, viruses and other contaminants.
"This facility greatly enhances the nanofabrication services available to researchers," said the facility's faculty director, Kang Wang, the Raytheon Professor of Physical Electronics at UCLA's Henry Samueli School of Engineering and Applied Science and an associate director of the CNSI. "By offering unique services like bio-suites capable of maintaining stringent cleanliness for biological applications, the ISNC is an excellent resource for companies interested in product development but who do not have access to a fully outfitted cleanroom."
As a shared resource facility, the ISNC is available to all researchers at UCLA, as well as those from other universities, industry and government. Like all the CNSI's core labs, the ISNC is open 24 hours a day, seven days a week. After setting up an account and undergoing training, researchers can book equipment using an online reservation system.
Equipped with tools like an electron-beam writer capable of fabricating nanoscale structures with device geometries as low as 10 nanometers and an ASML optical stepper capable of 0.3-micron resolution, the ISNC will also serve as a valuable resource for startup companies. Early-stage companies like those at UCLA's on-campus technology incubator at the CNSI don't have the resources to purchase millions of dollars worth of cleanroom equipment, though such equipment can be vital for their proof-of-concept work.
The ISNC is divided into 12 "aisles," or process bays, with adjacent support chases. Four of the aisles are rated at Class 100, meaning that each cubic foot of air contains less than 100 particles larger than 0.5 microns. To minimize contamination, the cleanroom has only one point of entry; researchers enter through a gowning area, where they are outfitted with a full cleanroom suit, including booties, gloves and a hood. The facility also includes six Class 1,000 aisles and two integrated bio-suite bays with their own isolated air supply for working with cells, tissues and other biological samples.
The integrated bio-suites were developed as a tool for researchers at Ronald Reagan UCLA Medical Center and the David Geffen School of Medicine at UCLA, both located on campus, less than five minutes from the CNSI. This proximity makes it is easy to transport live samples such as cells directly into the cleanroom.
"The bio-suites will be a vital tool for medical researchers," said CNSI associate director Leonard H. Rome, who is also senior associate dean for research at the Geffen School of Medicine and a professor of biological chemistry. "Nanotherapeutics is a very promising field, and the opening of the cleanroom will help bring medical diagnostics devices and treatments from research settings into actual use in medicine."
For researchers working on medical devices that must operate in biological environments, the ISNC provides a unique opportunity to do all the patterning and biological processes in a cleanroom environment, avoiding the problems of contamination encountered when moving devices between laboratories.
"The ISNC is up and running thanks to generous support from Intel, one of CNSI's founding industry partners," said Paul S. Weiss, CNSI director and Fred Kavli Professor of Nanosystems Sciences at UCLA. "Successes like this highlight CNSI's close collaborations with industry partners to commercialize nanoscience and nanotechnology research at UCLA."
In addition to support from Intel, significant equipment contributions came from ASML, Micron Technology Inc. and International Rectifier.
To maximize the cleanroom services offered on campus, the ISNC was developed as a complementary facility to the Nanoelectronics Research Facility (NRF) at UCLA's Henry Samueli School of Engineering and Applied Science. Each of these cleanrooms has its unique strengths — the ISNC with biological processes and patterning smaller features, and the NRF with electronics research. The partnership also provides ISNC staff with a valuable resource, as they are able to tap into the NRF staff's 20 years of experience.
About California NanoSystems Institute
The California NanoSystems Institute at UCLA is an integrated research facility located at UCLA and UC Santa Barbara. Its mission is to foster interdisciplinary collaborations in nanoscience and nanotechnology; to train a new generation of scientists, educators and technology leaders; to generate partnerships with industry; and to contribute to the economic development and the social well-being of California, the United States and the world. The CNSI was established in 2000 with $100 million from the state of California. An additional $850 million of support has come from federal research grants and industry funding. CNSI members are drawn from UCLA's College of Letters and Science, the David Geffen School of Medicine, the School of Dentistry, the School of Public Health and the Henry Samueli School of Engineering and Applied Science. They are engaged in measuring, modifying and manipulating atoms and molecules — the building blocks of our world. Their work is carried out in an integrated laboratory environment. This dynamic research setting has enhanced understanding of phenomena at the nanoscale and promises to produce important discoveries in health, energy, the environment and information technology.
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