Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Cheek Swab May Detect Lung Cancer

Nano-scale disturbances in cheek cells indicate the presence of lung cancer.
Nano-scale disturbances in cheek cells indicate the presence of lung cancer.

Abstract:
In clinical trial, technique appears to detect lung cancer far afield from a tumor

Cheek Swab May Detect Lung Cancer

Arlington, VA | Posted on October 7th, 2010

Early detection is critical for improving cancer survival rates. Yet, one of the deadliest cancers in the United States, lung cancer, is notoriously difficult to detect in its early stages.

Now, researchers have developed a method to detect lung cancer by merely shining diffuse light on cells swabbed from patients' cheeks.

In a new clinical study, the analysis technique--called partial wave spectroscopic (PWS) microscopy--was able to differentiate individuals with lung cancer from those without, even if the non-cancerous patients had been lifetime smokers or suffered from chronic obstructive pulmonary disease (COPD).

The findings-released by a team of engineers and physicians from NorthShore University Health System, Northwestern University and New York University-appear in print in the Oct. 15, 2010, issue of the journal Cancer Research.

"This study is important because it provides the proof of concept that a minimally intrusive, risk-stratification technique may allow us to tailor screening for lung cancer, the leading cause of cancer deaths in Americans," said physician and researcher Hemant Roy of NorthShore University HealthSystems and the University of Chicago, the lead author on the paper. "This represents a major step forward in translating biomedical optics breakthroughs for personalized screening for lung cancer."

The recent results are an extension of several successful trials involving the light-scattering analysis technique, including early detection successes with pancreatic cancer and colon cancer. NSF has supported the team's work since 2002, with an early grant to Roy's collaborator and co-author, bioengineer Vadim Backman of Northwestern University.

"Their work has now transitioned to a larger $2 million Emerging Frontiers in Research and Innovation award," said Leon Esterowitz, a biophotonics expert and program director at NSF who has long supported the research. "The results have even larger implications in that the techniques and the ‘field effect' may be a general phenomena that could be applied to a multitude of epithelial cancers, the most common cancer type."

The continuing clinical and laboratory experiments involving the PWS light-scattering technique-and its predecessor technologies, four-dimensional elastic light scattering fingerprinting (4D-ELF) and low-coherence enhanced backscattering spectroscopy (LEBS)-are revealing new information about the changes cells undergo when cancer emerges somewhere in the body.

Within affected cells, including otherwise healthy cells far from an actual tumor, the molecules in the nucleus and cellular skeleton appear to change. On the scale of roughly 200 nanometers or less, even to the scale of molecules, an affected cell's structure becomes so distorted that light scatters through the cell in a telling way.

The ability of cancer to cause changes in distant, healthy tissue is called the "field effect" or "field of injury" effect, and is the physical mechanism that allows cells in the cheek to reveal changes triggered by a tumor far off in a patient's lung.

"Microscopic histology and cytology have been a staple of clinical diagnostics detecting micro-scale alterations in cell structure," added Backman. "However, the resolution of conventional microscopy is limited. PWS-based nanocytology, on the other hand, detects cellular alterations at the nanoscale in otherwise microscopically normal-appearing cells."

"What is intriguing is that the very same nanoscale alterations seem to develop early in very different types of cancer including lung, colon and pancreatic cancers," Backman continued. "Not only does this suggest that nanocytology has the potential to become a general platform for cancer screening, but also that these nanoscale alterations are a ubiquitous event in early carcinogenesis with critical consequences for cell function. Elucidating the mechanisms of these alterations will help us understand the initial stages of carcinogenesis and improve screening."

This research was supported by the National Science Foundation through ten individual grants over the last decade, including CBET-0939778 and CBET-0937987.

####

About NSF
The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering. In fiscal year (FY) 2010, its budget is about $6.9 billion. NSF funds reach all 50 states through grants to nearly 2,000 universities and institutions. Each year, NSF receives over 45,000 competitive requests for funding, and makes over 11,500 new funding awards. NSF also awards over $400 million in professional and service contracts yearly.

For more information, please click here

Contacts:
Media Contacts
Joshua A. Chamot, NSF (703) 292-7730

Megan Fellman, Northwestern University (847) 491-3115

Jim Anthony, NorthShore University HealthSystem (847) 570-6132

Program Contacts
Sohi Rastegar, NSF (703) 292-8305
Leon Esterowitz, NSF (703) 292-7942


Principal Investigators
Vadim Backman, Northwestern University (847) 467-4010


Co-Investigators
Hemant Roy, NorthShore University HealthSystems and the University of Chicago

Copyright © NSF

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Possible Futures

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker November 17th, 2016

Announcements

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Nanobiotechnology

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Making spintronic neurons sing in unison November 18th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project