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September 20th, 2010
Finding the Right Formula
The Biological Test Center in Irvine, Calif., which focuses on drug dosage formulations, reports that due to the insolubility of certain compounds, nanotechnology is moving to the forefront. For both commercial and experimental ophthalmic compounds, the company has seen an increase in testing of implantable drug coated or controlled-release delivery devices.
"The days when a simple salt of a molecule would provide all of the solubility and stability required appear to be behind us," says Velasco's Barnes. "This actually provides a great opportunity for formulators to save an otherwise good drug molecule from oblivion. There is also the added benefit of patent life extension to be gained by companies who invest in formulating these challenging compounds."
Companies also are looking at formulation as a way to alter toxicology profiles, change bioavailability, or deliver drugs to particular sites, according to Charles River. Time release formulations, depot formulations, formulations that are used with special devices to administer the drug, and use of nanoparticles to change the distribution of drugs in cells and tissues are becoming more and more complex.
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