Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Developments in Nanobiotechnology at UCSB Point to Medical Applications

Top row, three different RNA objects rendered from molecular computer models: from left, RNA antiprism composed of eight RNAs, a six-stranded RNA cube, and a 10-stranded RNA cube. Bottom row, the corresponding three-dimensional reconstructions of the objects obtained from cryo-electron microscopy. Credit: Cody Geary and Kirill A. Afonin
Top row, three different RNA objects rendered from molecular computer models: from left, RNA antiprism composed of eight RNAs, a six-stranded RNA cube, and a 10-stranded RNA cube. Bottom row, the corresponding three-dimensional reconstructions of the objects obtained from cryo-electron microscopy. Credit: Cody Geary and Kirill A. Afonin

Abstract:
Two new groundbreaking scientific papers by researchers at UC Santa Barbara demonstrate the synthesis of nanosize biological particles with the potential to fight cancer and other illnesses. The studies introduce new approaches that are considered "green" nanobiotechnology because they use no artificial compounds.

Developments in Nanobiotechnology at UCSB Point to Medical Applications

Santa Barbara, CA | Posted on September 3rd, 2010

Luc Jaeger, associate professor of chemistry and biochemistry at UCSB, explained that there is nothing short of a revolution going on in his field -- one that permeates all areas of biochemistry, especially his area of nanobiotechnology. The revolution involves understanding the role of RNA in cells.

"Considering the fact that up to 90 percent of the human genome is transcribed into RNA, it becomes clear that RNA is one of the most important biopolymers on which life is based," said Jaeger. "We are still far from understanding all the tremendous implications of RNA in living cells."

Jaeger's team is putting together complex three-dimensional RNA molecules -- nanosize polyhedrons that could be used to fight disease. The molecules self assemble into the new shapes. The work is funded by the National Institutes of Health (NIH), and there is a patent pending jointly between NIH and UCSB on the new designs.

"We are interested in using RNA assemblies to deliver silencing RNAs and therapeutic RNA aptamers to target cancer and other diseases," said Jaeger. "It is clear that RNA is involved in a huge number of key processes that are related to health issues."

Jaeger believes the RNA-based approaches to delivering new therapies in the body will be safer than those using artificial compounds that might have undesirable side effects down the line.

"By using RNA molecules as our primary medium, we are practicing ‘green' nanobiotechnology," explained Jaeger. "The research program developed in my lab at UCSB aims at contributing in a positive way to medicine and synthetic biology. We try to avoid any approaches that raise controversial bioethical issues in the public square. It's not an easy task, but I am convinced that it will pay off in the long run."

The more recent of the two scientific papers describing the new work -- "In vitro assembly of cubic RNA-based scaffolds designed in silicon" -- published online Monday, August 30, by Nature Nanotechnology. The earlier paper -- "A polyhedron made of tRNAs" by Severcan and colleagues -- was published online on July 18 by Nature Chemistry. The print edition of this article will be published in Nature Chemistry's September issue.

The second author on the Nature Chemistry paper is Cody Geary, a postdoctoral fellow in Jaeger's lab. Kirill A. Afonin, also a postdoctoral fellow in Jaeger's lab, is the first author on the Nature Nanotechnnology article.

Bruce Shapiro, a senior author on the Nature Nanotechnology article, is based at the National Cancer Institute in Frederick, Md. and is also funded by NIH. Jaeger and his team worked with Shapiro to develop a computerized approach for facilitating the design of self-assembling RNA strands. Further assistance came from the National Resource for Automated Molecular Microscopy located at Scripps Institute in La Jolla, Calif.

####

For more information, please click here

Contacts:
Gail Gallessich
805-893-7220

George Foulsham
805-893-3071

Copyright © UC Santa Barbara

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Chemistry

Tokyo Institute of Technology research: Catalyst redefines rate limitations in ammonia production March 30th, 2015

Chemists make new silicon-based nanomaterials March 27th, 2015

First proof of isolated attosecond pulse generation at the carbon K-edge March 20th, 2015

Click! That's how modern chemistry bonds nanoparticles to a substrate March 19th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

SUNY Poly CNSE and Title Sponsor SEFCU Name Capital Region Teams Advancing to the Final Round of the 2015 New York Business Plan Competition March 30th, 2015

Princess Margaret scientists convert microbubbles to nanoparticles: Harnessing light to advance tumor imaging, provide platform for targeted treatment March 30th, 2015

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Possible Futures

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanocomposites Market Growth, Industry Outlook To 2020 by Grand View Research, Inc. March 21st, 2015

Nanotechnology Drug Delivery Market in the US 2012-2016 : Latest Report Available by Radiant Insights, Inc March 16th, 2015

Academic/Education

SUNY Poly CNSE and Title Sponsor SEFCU Name Capital Region Teams Advancing to the Final Round of the 2015 New York Business Plan Competition March 30th, 2015

LAMDAMAP 2015 hosted by the University March 26th, 2015

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

SUNY POLY CNSE to Host First Ever Northeast Semi Supply Conference (NESCO) Conference Will Connect New and Emerging Innovators in the Northeastern US and Canada with Industry Leaders and Strategic Investors to Discuss Future Growth Opportunities in NYS March 25th, 2015

Self Assembly

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Four Scientists With Major Contributions to Research at Brookhaven Lab Named American Physical Society Fellows March 17th, 2015

Nanotubes self-organize and wiggle: Evolution of a nonequilibrium system demonstrates MEPP February 10th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

Nanomedicine

Nanion Technologies Appoints James Costantin as Director of Customer Relations: Nanion is pleased to announce the appointment of Dr. James Costantin as Director of Customer Relations at Nanion Technologies Inc. March 31st, 2015

Nanomedicine shines light on combined force of nanomedicine and regenerative medicine March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Announcements

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Environment

Young NTU Singapore spin-off clinches S$4.3 million joint venture with Chinese commercial giant March 23rd, 2015

New processing technology converts packing peanuts to battery components March 22nd, 2015

EU Funded PCATDES Project has completed its half-period with success March 19th, 2015

Are current water treatment methods sufficient to remove harmful engineered nanoparticle? March 10th, 2015

Nanobiotechnology

From tobacco to cyberwood March 31st, 2015

Wrapping carbon nanotubes in polymers enhances their performance: Scientists at Japan's Kyushu University say polymer-wrapped carbon nanotubes hold much promise in biotechnology and energy applications March 30th, 2015

'Atomic chicken-wire' is key to faster DNA sequencing March 30th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE