Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Developments in Nanobiotechnology at UCSB Point to Medical Applications

Top row, three different RNA objects rendered from molecular computer models: from left, RNA antiprism composed of eight RNAs, a six-stranded RNA cube, and a 10-stranded RNA cube. Bottom row, the corresponding three-dimensional reconstructions of the objects obtained from cryo-electron microscopy. Credit: Cody Geary and Kirill A. Afonin
Top row, three different RNA objects rendered from molecular computer models: from left, RNA antiprism composed of eight RNAs, a six-stranded RNA cube, and a 10-stranded RNA cube. Bottom row, the corresponding three-dimensional reconstructions of the objects obtained from cryo-electron microscopy. Credit: Cody Geary and Kirill A. Afonin

Abstract:
Two new groundbreaking scientific papers by researchers at UC Santa Barbara demonstrate the synthesis of nanosize biological particles with the potential to fight cancer and other illnesses. The studies introduce new approaches that are considered "green" nanobiotechnology because they use no artificial compounds.

Developments in Nanobiotechnology at UCSB Point to Medical Applications

Santa Barbara, CA | Posted on September 3rd, 2010

Luc Jaeger, associate professor of chemistry and biochemistry at UCSB, explained that there is nothing short of a revolution going on in his field -- one that permeates all areas of biochemistry, especially his area of nanobiotechnology. The revolution involves understanding the role of RNA in cells.

"Considering the fact that up to 90 percent of the human genome is transcribed into RNA, it becomes clear that RNA is one of the most important biopolymers on which life is based," said Jaeger. "We are still far from understanding all the tremendous implications of RNA in living cells."

Jaeger's team is putting together complex three-dimensional RNA molecules -- nanosize polyhedrons that could be used to fight disease. The molecules self assemble into the new shapes. The work is funded by the National Institutes of Health (NIH), and there is a patent pending jointly between NIH and UCSB on the new designs.

"We are interested in using RNA assemblies to deliver silencing RNAs and therapeutic RNA aptamers to target cancer and other diseases," said Jaeger. "It is clear that RNA is involved in a huge number of key processes that are related to health issues."

Jaeger believes the RNA-based approaches to delivering new therapies in the body will be safer than those using artificial compounds that might have undesirable side effects down the line.

"By using RNA molecules as our primary medium, we are practicing ‘green' nanobiotechnology," explained Jaeger. "The research program developed in my lab at UCSB aims at contributing in a positive way to medicine and synthetic biology. We try to avoid any approaches that raise controversial bioethical issues in the public square. It's not an easy task, but I am convinced that it will pay off in the long run."

The more recent of the two scientific papers describing the new work -- "In vitro assembly of cubic RNA-based scaffolds designed in silicon" -- published online Monday, August 30, by Nature Nanotechnology. The earlier paper -- "A polyhedron made of tRNAs" by Severcan and colleagues -- was published online on July 18 by Nature Chemistry. The print edition of this article will be published in Nature Chemistry's September issue.

The second author on the Nature Chemistry paper is Cody Geary, a postdoctoral fellow in Jaeger's lab. Kirill A. Afonin, also a postdoctoral fellow in Jaeger's lab, is the first author on the Nature Nanotechnnology article.

Bruce Shapiro, a senior author on the Nature Nanotechnology article, is based at the National Cancer Institute in Frederick, Md. and is also funded by NIH. Jaeger and his team worked with Shapiro to develop a computerized approach for facilitating the design of self-assembling RNA strands. Further assistance came from the National Resource for Automated Molecular Microscopy located at Scripps Institute in La Jolla, Calif.

####

For more information, please click here

Contacts:
Gail Gallessich
805-893-7220

George Foulsham
805-893-3071

Copyright © UC Santa Barbara

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Chemistry

Creating new materials with quantum effects for electronics January 29th, 2015

News and information

Advantest to Exhibit at SEMICON Korea in Seoul, South Korea February 4-6 Showcasing Broad Portfolio of Semiconductor Products, Technologies and Solutions January 29th, 2015

Park Systems Announces Innovations in Bio Cell Analysis with the Launch of Park NX-Bio, the only 3-in-1 Imaging Nanoscale Tool Available for Life Science Researchers January 29th, 2015

2015 Nanonics Image Contest January 29th, 2015

Iranian Scientists Use MOFs to Eliminate Dye Pollutants January 29th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Nanoscale Mirrored Cavities Amplify, Connect Quantum Memories: Advance could lead to quantum computing and the secure transfer of information over long-distance fiber optic networks January 28th, 2015

Detecting chemical weapons with a color-changing film January 28th, 2015

'Bulletproof' battery: Kevlar membrane for safer, thinner lithium rechargeables January 28th, 2015

Researchers Make Magnetic Graphene: UC Riverside research could lead to new multi-functional electronic devices January 27th, 2015

Possible Futures

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Nanotechnology in Energy Applications Market Research Report 2014-2018: Radiant Insights, Inc January 15th, 2015

'Mind the gap' between atomically thin materials December 23rd, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Academic/Education

Rice's Naomi Halas to direct Smalley Institute: Optics pioneer will lead Rice's multidisciplinary science institute January 15th, 2015

SUNY Board Appoints Dr. Alain Kaloyeros as Founding President of SUNY Polytechnic Institute January 13th, 2015

CNSE's Smart System Technology & Commercialization Center Successfully Recertifies as ISO 9001:2008 January 12th, 2015

SUNY Poly Now Accepting Applications to the Colleges of Nanoscale Science and Engineering for Fall 2015: Full Scholarships Available to Incoming CNSE Students January 7th, 2015

Self Assembly

Engineering self-assembling amyloid fibers January 26th, 2015

Revealed: How bacteria drill into our cells and kill them December 2nd, 2014

Live Images from the Nano-cosmos: Researchers watch layers of football molecules grow November 5th, 2014

Outsmarting Thermodynamics in Self-assembly of Nanostructures: Berkeley Lab reports method for symmetry-breaking in feedback-driven self-assembly of optical metamaterials November 4th, 2014

Nanomedicine

Made-in-Singapore rapid test kit detects dengue antibodies from saliva: IBN's MedTech innovation simplifies diagnosis of infectious diseases January 29th, 2015

Iranian Researchers Planning to Produce Edible Insulin January 28th, 2015

Nanoparticles that deliver oligonucleotide drugs into cells described in Nucleic Acid Therapeutics January 28th, 2015

Nanoliposomes Help Efforts to Cure Bacterial Infections January 27th, 2015

Announcements

Advantest to Exhibit at SEMICON Korea in Seoul, South Korea February 4-6 Showcasing Broad Portfolio of Semiconductor Products, Technologies and Solutions January 29th, 2015

Park Systems Announces Innovations in Bio Cell Analysis with the Launch of Park NX-Bio, the only 3-in-1 Imaging Nanoscale Tool Available for Life Science Researchers January 29th, 2015

2015 Nanonics Image Contest January 29th, 2015

Iranian Scientists Use MOFs to Eliminate Dye Pollutants January 29th, 2015

Environment

Iranian Scientists Use MOFs to Eliminate Dye Pollutants January 29th, 2015

Detection of Heavy Metals in Samples with Naked Eye January 26th, 2015

Magnetic Nanosorbents Able to Eliminate Chemical Contaminants January 19th, 2015

Malaysian Nanotechnology Company Nanopac Innovation Ltd. lists on the NSX January 19th, 2015

Nanobiotechnology

Spider electro-combs its sticky nano-filaments January 28th, 2015

Nanoshuttle wear and tear: It's the mileage, not the age January 26th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

DNA 'glue' could someday be used to build tissues, organs January 14th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE