Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Developments in Nanobiotechnology at UCSB Point to Medical Applications

Top row, three different RNA objects rendered from molecular computer models: from left, RNA antiprism composed of eight RNAs, a six-stranded RNA cube, and a 10-stranded RNA cube. Bottom row, the corresponding three-dimensional reconstructions of the objects obtained from cryo-electron microscopy. Credit: Cody Geary and Kirill A. Afonin
Top row, three different RNA objects rendered from molecular computer models: from left, RNA antiprism composed of eight RNAs, a six-stranded RNA cube, and a 10-stranded RNA cube. Bottom row, the corresponding three-dimensional reconstructions of the objects obtained from cryo-electron microscopy. Credit: Cody Geary and Kirill A. Afonin

Abstract:
Two new groundbreaking scientific papers by researchers at UC Santa Barbara demonstrate the synthesis of nanosize biological particles with the potential to fight cancer and other illnesses. The studies introduce new approaches that are considered "green" nanobiotechnology because they use no artificial compounds.

Developments in Nanobiotechnology at UCSB Point to Medical Applications

Santa Barbara, CA | Posted on September 3rd, 2010

Luc Jaeger, associate professor of chemistry and biochemistry at UCSB, explained that there is nothing short of a revolution going on in his field -- one that permeates all areas of biochemistry, especially his area of nanobiotechnology. The revolution involves understanding the role of RNA in cells.

"Considering the fact that up to 90 percent of the human genome is transcribed into RNA, it becomes clear that RNA is one of the most important biopolymers on which life is based," said Jaeger. "We are still far from understanding all the tremendous implications of RNA in living cells."

Jaeger's team is putting together complex three-dimensional RNA molecules -- nanosize polyhedrons that could be used to fight disease. The molecules self assemble into the new shapes. The work is funded by the National Institutes of Health (NIH), and there is a patent pending jointly between NIH and UCSB on the new designs.

"We are interested in using RNA assemblies to deliver silencing RNAs and therapeutic RNA aptamers to target cancer and other diseases," said Jaeger. "It is clear that RNA is involved in a huge number of key processes that are related to health issues."

Jaeger believes the RNA-based approaches to delivering new therapies in the body will be safer than those using artificial compounds that might have undesirable side effects down the line.

"By using RNA molecules as our primary medium, we are practicing ‘green' nanobiotechnology," explained Jaeger. "The research program developed in my lab at UCSB aims at contributing in a positive way to medicine and synthetic biology. We try to avoid any approaches that raise controversial bioethical issues in the public square. It's not an easy task, but I am convinced that it will pay off in the long run."

The more recent of the two scientific papers describing the new work -- "In vitro assembly of cubic RNA-based scaffolds designed in silicon" -- published online Monday, August 30, by Nature Nanotechnology. The earlier paper -- "A polyhedron made of tRNAs" by Severcan and colleagues -- was published online on July 18 by Nature Chemistry. The print edition of this article will be published in Nature Chemistry's September issue.

The second author on the Nature Chemistry paper is Cody Geary, a postdoctoral fellow in Jaeger's lab. Kirill A. Afonin, also a postdoctoral fellow in Jaeger's lab, is the first author on the Nature Nanotechnnology article.

Bruce Shapiro, a senior author on the Nature Nanotechnology article, is based at the National Cancer Institute in Frederick, Md. and is also funded by NIH. Jaeger and his team worked with Shapiro to develop a computerized approach for facilitating the design of self-assembling RNA strands. Further assistance came from the National Resource for Automated Molecular Microscopy located at Scripps Institute in La Jolla, Calif.

####

For more information, please click here

Contacts:
Gail Gallessich
805-893-7220

George Foulsham
805-893-3071

Copyright © UC Santa Barbara

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

Chemistry

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides July 13th, 2018

The Institute of Applied Physics at the University of Tsukuba near Tokyo in Japan uses Deben's ARM2 detector to better understand catalytic reaction mechanisms June 27th, 2018

Quantum Interference May Be Key to Smaller Insulators: Breakthrough could jumpstart further miniaturization of transistors June 6th, 2018

Density gradient ultracentrifugation for colloidal nanostructures separation and investigation June 5th, 2018

Govt.-Legislation/Regulation/Funding/Policy

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

Possible Futures

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Academic/Education

The Institute of Applied Physics at the University of Tsukuba near Tokyo in Japan uses Deben's ARM2 detector to better understand catalytic reaction mechanisms June 27th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

SUNY Poly Professor Eric Lifshin Selected for ‘Fellow of the Microanalysis Society’ Position for Significant Contributions to Microanalysis June 13th, 2018

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Self Assembly

DNA drives design principles for lighter, thinner optical displays: Lighter gold nanoparticles could replace thicker, heavier layered polymers used in displays’ back-reflectors June 27th, 2018

Collaboration yields discovery of 12-sided silica cages June 20th, 2018

Self-assembling 3D battery would charge in seconds May 22nd, 2018

Engineered polymer membranes could be new option for water treatment May 6th, 2018

Nanomedicine

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Announcements

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Environment

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

Nanomaterials could mean more algae outbreaks for wetlands, waterways: High tech metal particles may inadvertently take a toll on aquatic life June 26th, 2018

Squeezing light at the nanoscale: Ultra-confined light could detect harmful molecules June 17th, 2018

A nanotech sensor that turns molecular fingerprints into bar codes June 7th, 2018

Nanobiotechnology

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Arrowhead Presents New Clinical Data on ARO-AAT at Alpha-1 National Education Conference July 1st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project