Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New pump created for microneedle drug-delivery patch

Babak Ziaie, a Purdue professor of electrical and computer engineering and biomedical engineering, shows a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches. (Purdue University photo/Mark Simons)
Babak Ziaie, a Purdue professor of electrical and computer engineering and biomedical engineering, shows a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches. (Purdue University photo/Mark Simons)

Abstract:
Purdue University researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.

New pump created for microneedle drug-delivery patch

West Lafayette, IN | Posted on September 1st, 2010

The current "transdermal" patches are limited to delivering drugs that, like nicotine, are made of small hydrophobic molecules that can be absorbed through the skin, said Babak Ziaie, a professor of electrical and computer engineering and biomedical engineering.

"There are only a handful of drugs that currently can be administered with patches," he said. "Most new drugs are large molecules that won't go through the skin. And a lot of drugs, such as those for treating cancer and autoimmune disorders, you can't take orally because they aren't absorbed into the blood system through the digestive tract."

Patches that used arrays of tiny microneedles could deliver a multitude of drugs, and the needles do not cause pain because they barely penetrate the skin, he said.

"It's like a bandage - you would use it and discard," Ziaie said.

The patches require a pump to push the drugs through the narrow needles, which have a diameter of about 20 microns, or roughly one-fourth as wide as a human hair. However, pumps on the market are too complex for patches, he said.

"We have developed a simple pump that's activated by touch from the heat of your finger and requires no battery," Ziaie said.

The pump contains a liquid that boils at body temperature so that the heat from a finger's touch causes it to rapidly turn to a vapor, exerting enough pressure to force drugs through the microneedles.

"It takes 20 to 30 seconds," Ziaie said.

The liquid is contained in a pouch separated from the drug by a thin membrane made of a rubberlike polymer, called polydimethylsiloxane, which is used as diaphragms in pumps.

Research findings are detailed in a paper being presented during the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences on Oct. 3-7 at University of Groningen in The Netherlands. The paper was written by electrical and computer engineering doctoral students Charilaos Mousoulis and Manuel Ochoa and Ziaie.

Researchers have filed an application for a provisional patent on the device.

Ziaie has tested prototypes with liquids called fluorocarbons, which are used as refrigerants and also in semiconductor manufacturing.

"You need a relatively large force, a few pounds per square inch, to push medications through the microneedles and into the skin," Ziaie said. "It's very difficult to find a miniature pump that can provide that much force."

Findings indicate prototypes using the fluorocarbon HFE-7000 exerted 4.87 psi and another fluorocarbon, FC-3284, exerted 2.24 psi.

The work has been supported with funding from the National Science Foundation. Future research may include work to try the pump with microneedles.

ABSTRACT

A Skin-Contact-Actuated Dispenser/Pump for Transdermal Drug Delivery


C. Mousoulis1*, M. Ochoa1, D. Papageorgiou2 and B. Ziaie1

1Birck Nanotechnology Center, Purdue University

2Solid-State Research Inc.


In this paper, a skin-contact-actuated dispenser/pump is described. The dispenser consists of stacked PDMS layers mounted on a silicon substrate and operates based on the evaporation and condensation of a low boiling point liquid. Therefore, there is no need for a heater or a battery, since the only required source of energy is the heat provided by skin contact. A prototype device with overall dimensions of 14mm~14 mm~8mm is fabricated and characterized. For a per-fluoro compound working fluid (3MTM FC-3284), a flow rate of 60L/min and a maximum back pressure of 4.19 psi is measured.

####

For more information, please click here

Contacts:
Writer: Emil Venere, 765-494-4709,

Source: Babak Ziaie, 765-494-0725,

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

NUS researchers achieve major breakthrough in flexible electronics: New classes of printable electrically conducting polymer materials make better electrodes for plastic electronics and advanced semiconductor devices January 14th, 2017

Manchester scientists tie the tightest knot ever achieved January 13th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Nanoscale view of energy storage January 16th, 2017

Chemistry on the edge: Experiments at Berkeley Lab confirm that structural defects at the periphery are key in catalyst function January 13th, 2017

Recreating conditions inside stars with compact lasers: Scientists offer a new path to creating the extreme conditions found in stars, using ultra-short laser pulses irradiating nanowires January 12th, 2017

New laser based on unusual physics phenomenon could improve telecommunications, computing January 12th, 2017

Possible Futures

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

NUS researchers achieve major breakthrough in flexible electronics: New classes of printable electrically conducting polymer materials make better electrodes for plastic electronics and advanced semiconductor devices January 14th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Arrowhead Provides Response to New Minority Shareholder Announcement January 7th, 2017

Announcements

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

NUS researchers achieve major breakthrough in flexible electronics: New classes of printable electrically conducting polymer materials make better electrodes for plastic electronics and advanced semiconductor devices January 14th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project