Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > New pump created for microneedle drug-delivery patch

Babak Ziaie, a Purdue professor of electrical and computer engineering and biomedical engineering, shows a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches. (Purdue University photo/Mark Simons)
Babak Ziaie, a Purdue professor of electrical and computer engineering and biomedical engineering, shows a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches. (Purdue University photo/Mark Simons)

Abstract:
Purdue University researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.

New pump created for microneedle drug-delivery patch

West Lafayette, IN | Posted on September 1st, 2010

The current "transdermal" patches are limited to delivering drugs that, like nicotine, are made of small hydrophobic molecules that can be absorbed through the skin, said Babak Ziaie, a professor of electrical and computer engineering and biomedical engineering.

"There are only a handful of drugs that currently can be administered with patches," he said. "Most new drugs are large molecules that won't go through the skin. And a lot of drugs, such as those for treating cancer and autoimmune disorders, you can't take orally because they aren't absorbed into the blood system through the digestive tract."

Patches that used arrays of tiny microneedles could deliver a multitude of drugs, and the needles do not cause pain because they barely penetrate the skin, he said.

"It's like a bandage - you would use it and discard," Ziaie said.

The patches require a pump to push the drugs through the narrow needles, which have a diameter of about 20 microns, or roughly one-fourth as wide as a human hair. However, pumps on the market are too complex for patches, he said.

"We have developed a simple pump that's activated by touch from the heat of your finger and requires no battery," Ziaie said.

The pump contains a liquid that boils at body temperature so that the heat from a finger's touch causes it to rapidly turn to a vapor, exerting enough pressure to force drugs through the microneedles.

"It takes 20 to 30 seconds," Ziaie said.

The liquid is contained in a pouch separated from the drug by a thin membrane made of a rubberlike polymer, called polydimethylsiloxane, which is used as diaphragms in pumps.

Research findings are detailed in a paper being presented during the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences on Oct. 3-7 at University of Groningen in The Netherlands. The paper was written by electrical and computer engineering doctoral students Charilaos Mousoulis and Manuel Ochoa and Ziaie.

Researchers have filed an application for a provisional patent on the device.

Ziaie has tested prototypes with liquids called fluorocarbons, which are used as refrigerants and also in semiconductor manufacturing.

"You need a relatively large force, a few pounds per square inch, to push medications through the microneedles and into the skin," Ziaie said. "It's very difficult to find a miniature pump that can provide that much force."

Findings indicate prototypes using the fluorocarbon HFE-7000 exerted 4.87 psi and another fluorocarbon, FC-3284, exerted 2.24 psi.

The work has been supported with funding from the National Science Foundation. Future research may include work to try the pump with microneedles.

ABSTRACT

A Skin-Contact-Actuated Dispenser/Pump for Transdermal Drug Delivery


C. Mousoulis1*, M. Ochoa1, D. Papageorgiou2 and B. Ziaie1

1Birck Nanotechnology Center, Purdue University

2Solid-State Research Inc.


In this paper, a skin-contact-actuated dispenser/pump is described. The dispenser consists of stacked PDMS layers mounted on a silicon substrate and operates based on the evaporation and condensation of a low boiling point liquid. Therefore, there is no need for a heater or a battery, since the only required source of energy is the heat provided by skin contact. A prototype device with overall dimensions of 14mm~14 mm~8mm is fabricated and characterized. For a per-fluoro compound working fluid (3MTM FC-3284), a flow rate of 60L/min and a maximum back pressure of 4.19 psi is measured.

####

For more information, please click here

Contacts:
Writer: Emil Venere, 765-494-4709,

Source: Babak Ziaie, 765-494-0725,

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Govt.-Legislation/Regulation/Funding/Policy

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Scientists 'bend' elastic waves with new metamaterials that could have commercial applications: Materials could benefit imaging and military enhancements such as elastic cloaking January 23rd, 2015

Harper Government Supports Research Innovation in Western Canada January 22nd, 2015

EnvisioNano: An image contest hosted by the National Nanotechnology Initiative (NNI) January 22nd, 2015

Possible Futures

Nanotechnology in Energy Applications Market Research Report 2014-2018: Radiant Insights, Inc January 15th, 2015

'Mind the gap' between atomically thin materials December 23rd, 2014

A novel method for identifying the bodys noisiest networks November 19th, 2014

Researchers discern the shapes of high-order Brownian motions November 17th, 2014

Academic/Education

Rice's Naomi Halas to direct Smalley Institute: Optics pioneer will lead Rice's multidisciplinary science institute January 15th, 2015

SUNY Board Appoints Dr. Alain Kaloyeros as Founding President of SUNY Polytechnic Institute January 13th, 2015

CNSE's Smart System Technology & Commercialization Center Successfully Recertifies as ISO 9001:2008 January 12th, 2015

SUNY Poly Now Accepting Applications to the Colleges of Nanoscale Science and Engineering for Fall 2015: Full Scholarships Available to Incoming CNSE Students January 7th, 2015

Nanomedicine

Teijin to Participate in Nano Tech 2015 January 22nd, 2015

2nd International Conference on Infectious Diseases & Nanomedicine (December 15-18, 2015, Kathmandu, NEPAL) January 22nd, 2015

Anti-microbial coatings with a long-term effect for surfaces presentation at nano tech 2015 in Japan January 21st, 2015

A spoonful of sugar in silver nanoparticles to regulate their toxicity January 21st, 2015

Announcements

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE