Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Two Catalysts Are Better Than One

Karl Scheidt
Karl Scheidt

Abstract:
New catalytic process could be used to create pharmaceuticals with less chemical waste

By Megan Fellman

Two Catalysts Are Better Than One

Evanston, IL | Posted on July 28th, 2010

Much like two children in the back seat of a car, it can be challenging to get two catalysts to cooperate for the greater good. Now Northwestern University chemists have gotten two catalysts to work together on the same task -- something easily done by nature but a difficult thing to do in the laboratory.

The findings, published by the journal Nature Chemistry, will allow medicinal chemists to invent new reactions and produce valuable bioactive compounds faster with less impact on the environment.

Catalysis is inherently green chemistry. Catalytic reactions typically employ a single molecule (a catalyst) to enhance a reaction or make a reaction possible that wouldn't otherwise be possible. Since a catalyst only needs to be used in very small amounts, the potential to control chemical processes while reducing waste makes catalysis very attractive. The Northwestern team wanted to see if they could turn a good thing -- a single catalyst -- into something even better by employing two catalysts.

"In our new approach, we discovered a pair of catalysts that work cooperatively to produce valuable compounds for biomedical research, which is important given the demand for new pharmaceuticals of all kinds," said senior author Karl A. Scheidt, the Irving M. Klotz Professor of Chemistry in the Weinberg College of Arts and Sciences. "Cooperative catalysis -- using two catalysts instead of just one -- will help us develop important compounds faster and with less waste. It also opens up an exciting new area of catalysis to explore."

Scheidt and his team started with simple stock chemicals and ended up with a number of compounds that are potentially bioactive and similar to each other. In the reaction, catalyst one (a magnesium salt that acts as an electron-deficient "Lewis acid") activates one molecule, and catalyst two (a mimic of thiamine, a carbene and an electron-rich "Lewis base") activates a second molecule simultaneously. The two activated substrates come together. The result is rapid, efficient and controlled production of large amounts of a molecule called gamma-lactam, a key building block for many pharmaceuticals.

On paper, the two catalysts should bind together and not be that effective as catalysts, but, it turns out, they don't interact that tightly. Instead, when there is a substrate for each catalyst, they work in tandem. Before this discovery, no one had identified an electron-deficient metal Lewis acid that works with a carbene. (A carbene is a highly reactive, transient molecule in which a carbon atom has only two bonds versus the normal four.)

"Nature employs a lot of catalysis -- to do such crucial biological transformations as acylations, oxidations and reductions, but it's hard to do what nature does in a flask," said Scheidt, director of Northwestern's Center for Molecular Innovation and Drug Discovery. "Getting two catalysts that are seemingly incompatible to work together is a significant advance. Now we have a great first step to realizing the full potential of this powerful cooperative catalysis strategy. Ultimately, this approach should allow chemists to combine simple components under catalytic conditions to generate new bioactive compounds of high value."

The National Institute of General Medical Sciences and the Alfred P. Sloan Foundation supported the research.

In addition to Scheidt, other authors of the paper are Dustin E. A. Raup, Benoit Cardinal-David and Dane Holte, all from Northwestern.

####

For more information, please click here

Contacts:
Megan Fellman

Copyright © Northwestern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Canatu Launches CNB In-Mold Film for Transparent Touch on 3D Surfaces –in Cars, Household Appliances, Wearables, Portables November 20th, 2014

Chemistry

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Two sensors in one: Nanoparticles that enable both MRI and fluorescent imaging could monitor cancer, other diseases November 18th, 2014

Application of Nanocomposites in Production of Photocatalysts for Water Treatment November 17th, 2014

Possible Futures

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Researchers discern the shapes of high-order Brownian motions November 17th, 2014

VDMA Electronics Production Equipment: Growth track for 2014 and 2015 confirmed: Business climate survey shows robust industry sector November 14th, 2014

Open Materials Development Will Be Key for HP's Success in 3D Printing: HP can make a big splash in 3D printing, but it needs to shore up technology claims and avoid the temptation of the razor/razor blade business model in order to flourish November 11th, 2014

Academic/Education

SUNY Poly Student Awarded Fellowship with the U.S. Department of Energy's Postgraduate Research Program: Ph.D. Candidate Accepts Postmaster's Appointment To Conduct Research At Albany NanoTech Complex November 13th, 2014

SUNY Polytechnic Institute Hosts Massive Crowd of More Than 3,000 People Who Attended Community Day Activities Across New York State: CNSE’s ‘NANOvember’ kickoff event highlights New York State’s growing high-tech sector with open house events in Albany, Utica, and Rochester November 3rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Nanomedicine

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

Announcements

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE