Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanoparticles Assembled Inside Tumors Trap Drugs and Imaging Agents

Abstract:
Virtually every study that uses nanoparticles to deliver drugs and imaging agents to tumors starts by loading the clinical payload into the nanoparticle and then injecting the resulting delivery agent into the body.

Nanoparticles Assembled Inside Tumors Trap Drugs and Imaging Agents

Bethesda, MD | Posted on July 19th, 2010

While effective at reducing clearance from the body and improving drug or imaging agent retention in a tumor, the nanoparticles do move relatively slowly from the circulation into the heart of the tumor.

Now, a pair of investigators from the University of Toronto have shown that a system that assembles itself into a nanoparticle, complete with drug or imaging agent, once it gets inside a tumor can dramatically increase the rate at which clinically important molecules get into tumors and still trap those molecules inside the tumor. Warren Chan and postdoctoral fellow Steven Perrault conducted the study and published the results of their work in the Proceedings of the National Academy of Sciences.

The goal of this project was to develop a nanoparticle system that would combine the fast "in" rate for small molecule drugs or imaging agents with the glacial "out" rate associated with nanoparticles. This would allow as much drug or imaging agent to get into and stay in tumors while allowing the body to excrete rapidly any of the active material that remained in the blood stream or that happened to get inside of non-targeted tissue. To create a system that would marry these two seemingly incompatible characteristics, Drs. Chan and Perrault first inject 30 nanometer diameter gold nanoparticles coated with a biotin terminated polymer; the polmer keeps the particles from sticking to one another and the biotin allows for later conjugation to imaging agents or drugs. Over the course of the next 24 hours, many of the gold nanoparticles accumulate in tumors, while the rest are excreted from the body.

Next, the researchers inject the active substance linked to streptavidin, a molecule that binds tightly and specifically to biotin. This small molecule construct readily enters tumors, as well as other tissues, but once in the tumors it sticks in an almost irreversible manner to the gold nanoparticles, greatly reducing the rate at which the active molecule will exit the tumor.

Using a fluorescent dye as the active molecule linked to streptavidin, Drs. Chan and Perrault were able to track the kinetics of drug accumulation in tumor. The results were remarkable: the active molecule accumulated nearly 200-fold increase in the rate at which drug accumulated in tumors compared to animals that did not receive the biotin-coated gold nanoparticles. In addition, pretreated tumors accumulated five times more of the fluorescent probe than did the control animals.

This work is detailed in a paper titled, "In vivo assembly of nanoparticle components to improve targeted cancer imaging." An abstract of this paper is available at the journal's Web site.

View abstract dx.doi.org/doi:10.1073/pnas.1001367107

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Phagraphene, a 'relative' of graphene, discovered September 2nd, 2015

A marine creature's magic trick explained: Crystal structures on the sea sapphire's back appear differently depending on the angle of reflection September 2nd, 2015

National Science Foundation Selects SUNY Poly CNSE for Expanded $2.1M Northeast Advanced Technological Education Center: NSF Center Locates to NanoCollege in Support of Flourishing Tech Industry in NYS September 1st, 2015

RUSNANOPRIZE Directorate Announces New Deadline for Nominations Submission – September 11, 2015 September 1st, 2015

Possible Futures

Sediment dwelling creatures at risk from nanoparticles in common household products August 13th, 2015

Harris & Harris Group Reports Financial Statements as of June 30, 2015, and Announces a Stock Repurchase Program August 10th, 2015

Molecular trick alters rules of attraction for non-magnetic metals August 5th, 2015

Global Carbon Nanotubes Industry 2015: Acute Market Reports August 4th, 2015

Academic/Education

Sustainable nanotechnology center September 1st, 2015

National Science Foundation Selects SUNY Poly CNSE for Expanded $2.1M Northeast Advanced Technological Education Center: NSF Center Locates to NanoCollege in Support of Flourishing Tech Industry in NYS September 1st, 2015

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

Kwansei Gakuin University in Hyogo, Japan, uses Raman microscopy to study crystallographic defects in silicon carbide wafers August 25th, 2015

Nanomedicine

Using DNA origami to build nanodevices of the future September 1st, 2015

Efficiency of Nanodrug Containing Antibiotics in Treatment of Infectious Diseases Evaluated August 31st, 2015

Researchers use DNA 'clews' to shuttle CRISPR-Cas9 gene-editing tool into cells August 30th, 2015

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Announcements

Phagraphene, a 'relative' of graphene, discovered September 2nd, 2015

A marine creature's magic trick explained: Crystal structures on the sea sapphire's back appear differently depending on the angle of reflection September 2nd, 2015

Waste coffee used as fuel storage: Scientists have developed a simple process to treat waste coffee grounds to allow them to store methane September 2nd, 2015

Nanotech could rid cattle of ticks, with less collateral damage September 1st, 2015

Nanobiotechnology

A marine creature's magic trick explained: Crystal structures on the sea sapphire's back appear differently depending on the angle of reflection September 2nd, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Researchers use DNA 'clews' to shuttle CRISPR-Cas9 gene-editing tool into cells August 30th, 2015

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic