Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticles Assembled Inside Tumors Trap Drugs and Imaging Agents

Abstract:
Virtually every study that uses nanoparticles to deliver drugs and imaging agents to tumors starts by loading the clinical payload into the nanoparticle and then injecting the resulting delivery agent into the body.

Nanoparticles Assembled Inside Tumors Trap Drugs and Imaging Agents

Bethesda, MD | Posted on July 19th, 2010

While effective at reducing clearance from the body and improving drug or imaging agent retention in a tumor, the nanoparticles do move relatively slowly from the circulation into the heart of the tumor.

Now, a pair of investigators from the University of Toronto have shown that a system that assembles itself into a nanoparticle, complete with drug or imaging agent, once it gets inside a tumor can dramatically increase the rate at which clinically important molecules get into tumors and still trap those molecules inside the tumor. Warren Chan and postdoctoral fellow Steven Perrault conducted the study and published the results of their work in the Proceedings of the National Academy of Sciences.

The goal of this project was to develop a nanoparticle system that would combine the fast "in" rate for small molecule drugs or imaging agents with the glacial "out" rate associated with nanoparticles. This would allow as much drug or imaging agent to get into and stay in tumors while allowing the body to excrete rapidly any of the active material that remained in the blood stream or that happened to get inside of non-targeted tissue. To create a system that would marry these two seemingly incompatible characteristics, Drs. Chan and Perrault first inject 30 nanometer diameter gold nanoparticles coated with a biotin terminated polymer; the polmer keeps the particles from sticking to one another and the biotin allows for later conjugation to imaging agents or drugs. Over the course of the next 24 hours, many of the gold nanoparticles accumulate in tumors, while the rest are excreted from the body.

Next, the researchers inject the active substance linked to streptavidin, a molecule that binds tightly and specifically to biotin. This small molecule construct readily enters tumors, as well as other tissues, but once in the tumors it sticks in an almost irreversible manner to the gold nanoparticles, greatly reducing the rate at which the active molecule will exit the tumor.

Using a fluorescent dye as the active molecule linked to streptavidin, Drs. Chan and Perrault were able to track the kinetics of drug accumulation in tumor. The results were remarkable: the active molecule accumulated nearly 200-fold increase in the rate at which drug accumulated in tumors compared to animals that did not receive the biotin-coated gold nanoparticles. In addition, pretreated tumors accumulated five times more of the fluorescent probe than did the control animals.

This work is detailed in a paper titled, "In vivo assembly of nanoparticle components to improve targeted cancer imaging." An abstract of this paper is available at the journal's Web site.

View abstract dx.doi.org/doi:10.1073/pnas.1001367107

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Possible Futures

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Researchers discern the shapes of high-order Brownian motions November 17th, 2014

VDMA Electronics Production Equipment: Growth track for 2014 and 2015 confirmed: Business climate survey shows robust industry sector November 14th, 2014

Open Materials Development Will Be Key for HP's Success in 3D Printing: HP can make a big splash in 3D printing, but it needs to shore up technology claims and avoid the temptation of the razor/razor blade business model in order to flourish November 11th, 2014

Academic/Education

SUNY Poly NanoCollege Faculty Member Selected as American Physical Society Fellow: SUNY Poly Associate Professor of Nanoscience Dr. Vincent LaBella Recognized for Significant Technological Innovations that Enable Interactive Learning December 17th, 2014

Nanomedicine expert joins Rice faculty: Gang Bao combines genetic, nano and imaging techniques to fight disease December 17th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

Student Nanotechnology Laboratories Network Set Up in Iran December 15th, 2014

Nanomedicine

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Announcements

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Nanobiotechnology

Scientists trace nanoparticles from plants to caterpillars: Rice University study examines how nanoparticles behave in food chain December 16th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope December 15th, 2014

Biomimetic dew harvesters: Understanding how a desert beetle harvests water from dew could improve drinking water collection in dew condensers December 8th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE