Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Sugar-Coated Nanotubes Deliver High-Dose Radiotherapy

Abstract:
Starting with simple carbon nanotubes, a team of researchers from the United Kingdom and Spain has developed a sugar-coated nanocapsule that can deliver large doses of radioactivity to tumors.

Sugar-Coated Nanotubes Deliver High-Dose Radiotherapy

Bethesda, MD | Posted on July 19th, 2010

The researchers envision developing a series of nanoscale delivery devices that can target specific organs in the body for radiation therapy or imaging by tinkering with the sugar coating on the nanocapsule.

The research team was led by Benjamin Davis of Oxford University, Kostas Kostarelos of the University of London, and , and Gerard Tobias of the Institut de Ciència de Materials de Barcelona. The investigators reported the results of their work in the journal Nature Materials.

To create their loaded nanotubes, the investigators prepare a mixture of carbon nanotubes and sodium iodide made from radioactive iodine-125 inside a silica ampoule and heated it to 900° C for four hours. When heated to this temperature, sodium iodide and other metal salts form nanocrystals inside the nanotubes. As the nanotubes cool, their ends self-seal, trapping the radioactive nanocrystals safely inside the carbon containers. After washing the sealed tubes to remove any salts that aren't encased, the researchers then perform a mild chemical reaction that leaves the end caps unaltered while adding chemical groups to which sugar molecules can attach. In a final step, the scientists add one of many types of sugar molecules to the nanotube surface. In this study, they used a simple sugar known as N-acetyl glucosamine. The researchers note that this synthetic scheme can be used to add other radioactive metal salts to nanotubes and to add other sugar molecules to the surface of the nanotubes.

Numerous tests showed that radioactive payload remained trapped in the sealed nanotubes under a variety of physiological conditions. When injected into tail vein of mice, the researchers were able to image the nanotubes as they accumulated in the lungs using a common imaging technology known as single photon emission computed tomography, or SPECT.

When injected into the body, free sodium iodide normally concentrates in the thyroid gland, not the lungs. The carbon nanotubes did not accumulate in liver, spleen, and kidneys or other organs that usually accumulate injected nanoparticles. The researchers hypothesize that N-acetyl glucosamine targets the nanotubes to the lung by binding to a lung-specific protein known to bind tightly to this sugar.

This work is detailed in a paper titled, "Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging." An abstract of this paper is available at the journal's Web site.

View abstract dx.doi.org/doi:10.1038/nmat2766

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Possible Futures

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

Nanotubes/Buckyballs

SouthWest NanoTechnologies Names NanoSperse as A SWeNT Certified Compounder July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

UCF Nanotech Spinout Developing Revolutionary Battery Technology: Power the Next Generation of Electronics with Carbon July 23rd, 2014

University of Houston researchers create new method to draw molecules from live cells: Technique using magnetic nanomaterials offers promise for diagnosis, gene therapy July 17th, 2014

Nanomedicine

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

New imaging agent provides better picture of the gut July 25th, 2014

Announcements

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Nanobiotechnology

Harris & Harris Group Invests in Unique NYC Biotech Accelerator July 29th, 2014

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

Research partnerships

Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster: University of Leicester research team unlocks insights into creation of new nano-materials July 25th, 2014

A*STAR and industry form S$200M semiconductor R&D July 25th, 2014

A Crystal Wedding in the Nanocosmos July 23rd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE