Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Sugar-Coated Nanotubes Deliver High-Dose Radiotherapy

Abstract:
Starting with simple carbon nanotubes, a team of researchers from the United Kingdom and Spain has developed a sugar-coated nanocapsule that can deliver large doses of radioactivity to tumors.

Sugar-Coated Nanotubes Deliver High-Dose Radiotherapy

Bethesda, MD | Posted on July 19th, 2010

The researchers envision developing a series of nanoscale delivery devices that can target specific organs in the body for radiation therapy or imaging by tinkering with the sugar coating on the nanocapsule.

The research team was led by Benjamin Davis of Oxford University, Kostas Kostarelos of the University of London, and , and Gerard Tobias of the Institut de Cičncia de Materials de Barcelona. The investigators reported the results of their work in the journal Nature Materials.

To create their loaded nanotubes, the investigators prepare a mixture of carbon nanotubes and sodium iodide made from radioactive iodine-125 inside a silica ampoule and heated it to 900° C for four hours. When heated to this temperature, sodium iodide and other metal salts form nanocrystals inside the nanotubes. As the nanotubes cool, their ends self-seal, trapping the radioactive nanocrystals safely inside the carbon containers. After washing the sealed tubes to remove any salts that aren't encased, the researchers then perform a mild chemical reaction that leaves the end caps unaltered while adding chemical groups to which sugar molecules can attach. In a final step, the scientists add one of many types of sugar molecules to the nanotube surface. In this study, they used a simple sugar known as N-acetyl glucosamine. The researchers note that this synthetic scheme can be used to add other radioactive metal salts to nanotubes and to add other sugar molecules to the surface of the nanotubes.

Numerous tests showed that radioactive payload remained trapped in the sealed nanotubes under a variety of physiological conditions. When injected into tail vein of mice, the researchers were able to image the nanotubes as they accumulated in the lungs using a common imaging technology known as single photon emission computed tomography, or SPECT.

When injected into the body, free sodium iodide normally concentrates in the thyroid gland, not the lungs. The carbon nanotubes did not accumulate in liver, spleen, and kidneys or other organs that usually accumulate injected nanoparticles. The researchers hypothesize that N-acetyl glucosamine targets the nanotubes to the lung by binding to a lung-specific protein known to bind tightly to this sugar.

This work is detailed in a paper titled, "Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging." An abstract of this paper is available at the journal's Web site.

View abstract dx.doi.org/doi:10.1038/nmat2766

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Spintronics for future information technologies: Spin currents in topological insulators controlled May 2nd, 2016

Possible Futures

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Nanotubes/Buckyballs/Fullerenes

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

NREL finds nanotube semiconductors well-suited for PV systems April 27th, 2016

Researchers create artificial protein to control assembly of buckyballs April 27th, 2016

Nanomedicine

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Announcements

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Spintronics for future information technologies: Spin currents in topological insulators controlled May 2nd, 2016

Nanobiotechnology

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Research partnerships

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic