Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Sugar-Coated Nanotubes Deliver High-Dose Radiotherapy

Abstract:
Starting with simple carbon nanotubes, a team of researchers from the United Kingdom and Spain has developed a sugar-coated nanocapsule that can deliver large doses of radioactivity to tumors.

Sugar-Coated Nanotubes Deliver High-Dose Radiotherapy

Bethesda, MD | Posted on July 19th, 2010

The researchers envision developing a series of nanoscale delivery devices that can target specific organs in the body for radiation therapy or imaging by tinkering with the sugar coating on the nanocapsule.

The research team was led by Benjamin Davis of Oxford University, Kostas Kostarelos of the University of London, and , and Gerard Tobias of the Institut de Cičncia de Materials de Barcelona. The investigators reported the results of their work in the journal Nature Materials.

To create their loaded nanotubes, the investigators prepare a mixture of carbon nanotubes and sodium iodide made from radioactive iodine-125 inside a silica ampoule and heated it to 900° C for four hours. When heated to this temperature, sodium iodide and other metal salts form nanocrystals inside the nanotubes. As the nanotubes cool, their ends self-seal, trapping the radioactive nanocrystals safely inside the carbon containers. After washing the sealed tubes to remove any salts that aren't encased, the researchers then perform a mild chemical reaction that leaves the end caps unaltered while adding chemical groups to which sugar molecules can attach. In a final step, the scientists add one of many types of sugar molecules to the nanotube surface. In this study, they used a simple sugar known as N-acetyl glucosamine. The researchers note that this synthetic scheme can be used to add other radioactive metal salts to nanotubes and to add other sugar molecules to the surface of the nanotubes.

Numerous tests showed that radioactive payload remained trapped in the sealed nanotubes under a variety of physiological conditions. When injected into tail vein of mice, the researchers were able to image the nanotubes as they accumulated in the lungs using a common imaging technology known as single photon emission computed tomography, or SPECT.

When injected into the body, free sodium iodide normally concentrates in the thyroid gland, not the lungs. The carbon nanotubes did not accumulate in liver, spleen, and kidneys or other organs that usually accumulate injected nanoparticles. The researchers hypothesize that N-acetyl glucosamine targets the nanotubes to the lung by binding to a lung-specific protein known to bind tightly to this sugar.

This work is detailed in a paper titled, "Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging." An abstract of this paper is available at the journal's Web site.

View abstract dx.doi.org/doi:10.1038/nmat2766

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

Possible Futures

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

Nanotubes/Buckyballs/Fullerenes/Nanorods

Regulation of two-dimensional nanomaterials: New driving force for lithium-ion batteries July 26th, 2017

Killing cancer in the heat of the moment: A new method efficiently transfers genes into cells, then activates them with light. This could lead to gene therapies for cancers July 9th, 2017

Tests show no nanotubes released during utilisation of nanoaugmented materials June 9th, 2017

Ag/ZnO-Nanorods Schottky diodes based UV-PDs are fabricated and tested May 26th, 2017

Nanomedicine

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

Gold shines through properties of nano biosensors: Researchers discover that fluorescence in ligand-protected gold nanoclusters is an intrinsic property of the gold particles themselves August 16th, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Announcements

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

Nanobiotechnology

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

Gold shines through properties of nano biosensors: Researchers discover that fluorescence in ligand-protected gold nanoclusters is an intrinsic property of the gold particles themselves August 16th, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Research partnerships

Researchers printed graphene-like materials with inkjet August 17th, 2017

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

2-faced 2-D material is a first at Rice: Rice University materials scientists create flat sandwich of sulfur, molybdenum and selenium August 14th, 2017

Moving at the Speed of Light: University of Arizona selected for high-impact, industrial demonstration of new integrated photonic cryogenic datalink for focal plane arrays: Program is major milestone for AIM Photonics August 10th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project