Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > NIH awards Rice $1.7M for cartilage-regeneration research

Abstract:
Bioengineers explore whether adult stem cells can help heal joints

NIH awards Rice $1.7M for cartilage-regeneration research

Houston, TX | Posted on July 19th, 2010

Bioengineers from Rice University's BioScience Research Collaborative have won a $1.7 million grant from the National Institutes of Health to develop an injectable mix of polymers and adult stem cells that can spur the growth of new cartilage in injured knees and other joints.

"Millions of people live with pain, limited mobility and arthritis that often result from cartilage injuries, particularly those to the knee," said Rice researcher Kurt Kasper, a principal investigator on the new five-year grant. "By combining just enough of a patient's own stem cells with the proper mix of growth factors and polymers, we hope to allow the body to do something it cannot normally do -- fill in small gaps with healthy, new bone-protecting cartilage."

The research lies at the cutting-edge of basic science and engineering, and Kasper said a human treatment, if it proves feasible, would still be at least a decade away.

In joints like the knee, elbow and shoulder, a thin layer of cartilage covers and protects the bones at the point where they meet and rotate against one another. This "articular" cartilage is one of many types of cartilage found in the body, and it has wondrous material properties. For example, it's so impact-resistant and resilient that no currently available synthetic materials can stand up to the punishment it endures.

Because no synthetics can suitably replace articular cartilage, and because the body has almost no natural ability to repair it, Kasper and other researchers are looking for ways to reinforce and expand upon the healing abilities the body already has.

Rice's research team on the new project includes Kasper, a faculty fellow in the Department of Bioengineering, and Antonios Mikos, the Louis Calder Professor of Bioengineering, professor in chemical and biomolecular engineering and director of Rice's Center for Excellence in Tissue Engineering.

The team will use mesenchymal stem cells (MSCs), a type of stem cell that the body uses naturally to repair broken bones, injured skin and other tissues. Researchers have long known that MSCs can be coaxed into becoming cartilage-generating cells with the right combination of growth factors.

"We aim to find the optimal formulation of MSCs and growth factors for regenerating articular cartilage," Mikos said. "We will deliver that mix in a nontoxic, biodegradable polymer system that can be injected as a liquid and that gels quickly to form a temporary support matrix to guide the growth of the new cartilage."

Kasper said a unique aspect of the study is its focus on developing techniques that will allow the newly formed cartilage to attach naturally to the underlying bone in the joint. To do this, the team hopes to develop a two-layered system where the upper layer of articular cartilage is grown atop a segment of newly formed bone. A different formulation of growth factors and MSCs will be needed in each layer, and tests in animals will be used to determine the optimal mix that might be needed for future clinical translation to humans.

####

About Rice University
Located in Houston, Rice University is consistently ranked one of America's best teaching and research universities. Known for its "unconventional wisdom," Rice is distinguished by its: size -- 3,279 undergraduates and 2,277 graduate students; selectivity -- 12 applicants for each place in the freshman class; resources -- an undergraduate student-to-faculty ratio of 5-to-1; sixth largest endowment per student among American private research universities; residential college system, which builds communities that are both close-knit and diverse; and collaborative culture, which crosses disciplines, integrates teaching and research, and intermingles undergraduate and graduate work.

For more information, please click here

Contacts:
Jade Boyd
Associate Director and Science Editor
Office of Public Affairs/News & Media Relations
Rice University
(office) 713-348-6778
(cell) 713-302-2447

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

'Life Redesigned: The Emergence of Synthetic Biology' Lecture at Brookhaven Lab on Wednesday, April 30: Biomedical Engineer James Collins to Speak for BSA Distinguished Lecture Series April 16th, 2014

ECHA Planning Workshop on Regulatory Challenges in the Risk Assessment of Nanomaterials April 16th, 2014

Lumerical files a provisional patent that extends the standard eigenmode expansion propagation technique to better address waveguide component design. Lumerical’s EME propagation tool will address a wide set of waveguide applications in silicon photonics and integrated optics April 16th, 2014

Possible Futures

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

The "Tipping Point" February 12th, 2014

Academic/Education

Director Wally Pfister joins UC Berkeley neuroengineers to discuss the science behind ‘Transcendence’ April 7th, 2014

First annual science week highlights STEM pipeline and partnerships: UB, SUNY Buffalo State and ECC team up with the City of Buffalo and its schools for April 7-11 events April 3rd, 2014

Global 450 consortium announces new general manager of internal operations: TSMC’s Cheng-Chung Chien Receives Unanimous Support, Brings History of Innovation and Efficiency to Global Consortium of Companies Driving Industry Transition to 450mm Wafer Technology March 26th, 2014

NanoTecNexus to Host "Chemistry of Wine" Fundraiser in Support of STEM Education - Collaborations Key to Success - March 20th, 2014

Announcements

UT Arlington physicist creates new nanoparticle for cancer therapy April 16th, 2014

Relieving electric vehicle range anxiety with improved batteries: Lithium-sulfur batteries last longer with nanomaterial-packed cathode April 16th, 2014

Aerotech X-Y ball-screw stage for economical high performance Planar positioning April 16th, 2014

Energy Research Facility Construction Project at Brookhaven Lab Wins U.S. Energy Secretary's Achievement Award April 16th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Energy Research Facility Construction Project at Brookhaven Lab Wins U.S. Energy Secretary's Achievement Award April 16th, 2014

IDTechEx Printed Electronics Europe 2014 Award Winners April 1st, 2014

Dais Analytic Wins SBIR Grant: Dais Analytic Receives US Army Small Business Innovation Research Grant to Further Its Demonstrated Successes in Cleaning Most Forms of Wastewater March 28th, 2014

Scientists develop world’s first light-activated antimicrobial surface that also works in the dark March 24th, 2014

Research partnerships

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

Scalable CVD process for making 2-D molybdenum diselenide: Rice, NTU scientists unveil CVD production for coveted 2-D semiconductor April 8th, 2014

Carbon nanotubes grow in combustion flames April 1st, 2014

Never say never in the nano-world March 31st, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE