Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > CEA-Leti’s New Imaging System for fDOT Ready for Commercialization, Use in Measuring and Treating Cancer

Abstract:
Imaging System for Fluorescence Diffuse Optical Tomography Validated by Researchers at Five French Sites

CEA-Leti’s New Imaging System for fDOT Ready for Commercialization, Use in Measuring and Treating Cancer

Grenoble, France | Posted on July 9th, 2010

CEA-Leti today announced that after extensive beta testing at five French research facilities, its new imaging system for near-infrared fluorescence-enhanced diffuse optical tomography (fDOT) is ready for commercial applications.

fDOT systems help researchers quantify cancer activity and evaluate treatment efficiency. They provide quantitative functional measurements for the pharmacological industry in experiments on small animals, typically mice. After target-specific fluorescent molecular probes are injected into the mice, the probes' distribution in the tissue is reconstructed, enabling both 3D localization of the targeted areas and quantization of the local concentration of the fluorescent dye.

But fDOT existing systems are currently limited by the extent of tissue heterogeneity and the complex surface shape of the animals.

CEA-Leti's new fDOT imaging system enables reconstruction of the fluorescence yield even in heterogeneous and highly attenuating body regions such as the lungs, and it doesn't require immersing the mice in optical index-matching liquid.

After being injected with a cancer-specific fluorescent marker, the mice are scanned with near-infrared light over the area of interest. The system records outgoing transmitted and emitted fluorescent lights and reconstructs the 3D fluorescence map to infer cancer localization and activity. For in vivo experiments on small animals, the reconstruction method takes into account heterogeneous optical properties of the biological tissues and complex-shape-object geometries.

Research teams at five French beta-sites, including the Albert Bonniot Institute (IAB) in Grenoble, and Service Hospitalier Frédéric Joliot (SHJF) in Orsay near Paris, have validated CEA-Leti's fDOT systems in studies on more than 1 000 mice.

"This level of maturity in a new technology, which has been validated by five beta sites, demonstrates that our fDOT imaging system is ready for commercialization," said CEA-Leti CEO Laurent Malier. "These studies have shown high quality reconstruction results, particularly in terms of sensitivity, linearity and spatial resolution, all of which compare favorably to the top commercially available fDOT systems. We invite industrial partners to discuss ways to commercialize this system, including transfer of the technology, know-how and IP."

####

About CEA-Leti
CEA is a French research and technology public organisation, with activities in four main areas: energy, information technologies, healthcare technologies and defence and security. Within CEA, the Laboratory for Electronics & Information Technology (CEA-Leti) works with companies in order to increase their competitiveness through technological innovation and transfers. CEA-Leti is focused on micro and nanotechnologies and their applications, from wireless devices and systems, to biology and healthcare or photonics. Nanoelectronics and microsystems (MEMS) are at the core of its activities. As a major player in MINATEC excellence centre, CEA-Leti operates 8,000-m² state-of-the-art clean rooms, on 24/7 mode, on 200mm and 300mm wafer standards. With 1,200 employees, CEA-Leti trains more than 150 Ph.D. students and hosts 200 assignees from partner companies. Strongly committed to the creation of value for the industry, CEA-Leti puts a strong emphasis on intellectual property and owns more than 1,400 patent families. In 2008, contractual income covered more than 75 % of its budget worth 205 M€.

For more information, please click here

Contacts:
Technical Contact:
Jean-Louis AMANS
Program manager, imaging systems, CEA-Leti
+33 4 38 78 31 53


CEA-Leti
Thierry Bosc
+33 4 38 78 31 95


Agency
Amélie Ravier
+33 1 58 18 59 30

Copyright © CEA-Leti

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Graphene reduces wear of alumina ceramic March 26th, 2015

FEI Technology Award of the German Neuroscience Society Goes to Benjamin Judkewitz of the University of Berlin: Bi-annual award honors excellence in brain research during the German Neuroscience Society’s Annual Meeting, held 18-21 March 2015 March 26th, 2015

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

Hong Kong Investors Bullish on Dais Analytic Invest $5.75M, Provide $60M Contract, and Create New Joint Venture Company March 26th, 2015

Nanomedicine

Graphene reduces wear of alumina ceramic March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Nanorobotic agents open the blood-brain barrier, offering hope for new brain treatments March 25th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Announcements

Industrial Nanotech, Inc. Announces Next Large Order from the Oil and Gas Industry March 26th, 2015

Quantum compute this -- WSU mathematicians build code to take on toughest of cyber attacks: Revamped knapsack code offers online security for the future March 26th, 2015

Thousands of atoms entangled with a single photon: Result could make atomic clocks more accurate March 26th, 2015

Square ice filling for a graphene sandwich March 26th, 2015

Tools

FEI Technology Award of the German Neuroscience Society Goes to Benjamin Judkewitz of the University of Berlin: Bi-annual award honors excellence in brain research during the German Neuroscience Society’s Annual Meeting, held 18-21 March 2015 March 26th, 2015

Square ice filling for a graphene sandwich March 26th, 2015

Renishaw reports on the use of Raman spectroscopy at CNRS Orléans to study materials under extreme conditions March 25th, 2015

Nanorobotic agents open the blood-brain barrier, offering hope for new brain treatments March 25th, 2015

Nanobiotechnology

Dolomite’s microfluidics technology ideal for B cell encapsulation March 24th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

TGAC's take on the first portable DNA sequencing 'laboratory': First remote laboratory allows researchers to conduct real-time anaylsis March 19th, 2015

Super-resolution microscopes reveal the link between genome packaging and cell pluripotency: A study using super-resolution microscopy reveals that our genome is not regularly packaged and links these packaging differences to stem cell state March 12th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE