Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Smaller and Sharper

Abstract:
Nanoscale Metal-Organic Frameworks (NMOFs) as MRI Contrast Agents

Smaller and Sharper

Weinheim, Germany | Posted on July 8th, 2010

Developing more sensitive methods of biomedical imaging that are effective with minimal amounts of contrast agents is an important challenge in the early and accurate diagnosis of illnesses. A new class of materials that appear promising in this quest were introduced in 2006 by Prof. Wenbin Lin of the University of North Carolina at Chapel Hill. Ever since, this emerging area has been growing rapidly as new materials with improved properties are discovered. Wenbin Lin and Joseph Della Rocca present the progress in this field in the Microreview published in the European Journal of Inorganic Chemistry.

Magnetic resonance imaging (MRI) is a noninvasive technique based on the detection of nuclear spin reorientations in a magnetic field, which, however, is relatively insensitive and typically relies on large doses of administered contrast agents to distinguish adequately between normal and diseased tissues. Nanoscale Metal-Organic Frameworks (NMOFs) are combinations of metals and organic molecules on the nanoscale that provide unlimited possibilities for designing task-specific molecules. They are intrinsically biodegradable, and their high porosity makes them ideal for targeted delivery of entrapped agents. They can be specifically targeted to certain regions of the body. In addition to a wealth of applications in other fields, these properties make NMOFs also very suitable for use in biological systems and in particular as more effective contrast agents at lower doses. In addition to Gd carboxylate materials, NMOFs based on Fe, Mn, and Zn were investigated. Coatings such as amorphous silica, biocompatible polymers, and polyoxometalate-peptide hybrid spheres were used to enhance the stability, dispersibility, and biocompatibility of NMOFs. Furthermore, some systems doped with lanthanides were studied as potential multimodal contrast agents.

The in vivo and in vitro effectiveness of these agents has been demonstrated. For example, iron carboxylate NMOFs modified with biocompatible polymers were used for imaging the liver and spleen of Wistar rats. Silica-coated, peptide-targeted Mn NMOFs were shown to be selectively taken up by a human colon cancer cell line in vitro. Finally, a versatile iron carboxylate system post-synthetically modified to contain a fluorophore or a chemotherapeutic showed strong fluorescence upon release from the framework and exhibited cytotoxicity comparable to cisplatin against colon cancer cells.

Author: Wenbin Lin, University of North Carolina, Chapel Hill (USA), www.unc.edu/~wlin/

Title: Nanoscale Metal-Organic Frameworks: Magnetic Resonance Imaging Contrast Agents and Beyond

European Journal of Inorganic Chemistry, Permalink to the article: dx.doi.org/10.1002/ejic.201000496

####

For more information, please click here

Copyright © European Journal of Inorganic Chemistry

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

Possible Futures

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Nanotechnology in Energy Applications Market Research Report 2014-2018: Radiant Insights, Inc January 15th, 2015

'Mind the gap' between atomically thin materials December 23rd, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Academic/Education

Rice's Naomi Halas to direct Smalley Institute: Optics pioneer will lead Rice's multidisciplinary science institute January 15th, 2015

SUNY Board Appoints Dr. Alain Kaloyeros as Founding President of SUNY Polytechnic Institute January 13th, 2015

CNSE's Smart System Technology & Commercialization Center Successfully Recertifies as ISO 9001:2008 January 12th, 2015

SUNY Poly Now Accepting Applications to the Colleges of Nanoscale Science and Engineering for Fall 2015: Full Scholarships Available to Incoming CNSE Students January 7th, 2015

Nanomedicine

Teijin to Participate in Nano Tech 2015 January 22nd, 2015

2nd International Conference on Infectious Diseases & Nanomedicine (December 15-18, 2015, Kathmandu, NEPAL) January 22nd, 2015

Anti-microbial coatings with a long-term effect for surfaces – presentation at nano tech 2015 in Japan January 21st, 2015

A spoonful of sugar in silver nanoparticles to regulate their toxicity January 21st, 2015

Announcements

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

Nanobiotechnology

DNA 'glue' could someday be used to build tissues, organs January 14th, 2015

Photonic crystal nanolaser biosensor simplifies DNA detection: New device offers a simpler and potentially less expensive way to detect DNA and other biomolecules through changes in surface charge density or solution pH January 13th, 2015

Determination of Critical Force, Time for Manipulation of Biological Nanoparticles January 7th, 2015

DNA Origami Could Lead to Nano “Transformers” for Biomedical Applications: Tiny hinges and pistons hint at possible complexity of future nano-robots January 5th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE