Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Smaller and Sharper

Abstract:
Nanoscale Metal-Organic Frameworks (NMOFs) as MRI Contrast Agents

Smaller and Sharper

Weinheim, Germany | Posted on July 8th, 2010

Developing more sensitive methods of biomedical imaging that are effective with minimal amounts of contrast agents is an important challenge in the early and accurate diagnosis of illnesses. A new class of materials that appear promising in this quest were introduced in 2006 by Prof. Wenbin Lin of the University of North Carolina at Chapel Hill. Ever since, this emerging area has been growing rapidly as new materials with improved properties are discovered. Wenbin Lin and Joseph Della Rocca present the progress in this field in the Microreview published in the European Journal of Inorganic Chemistry.

Magnetic resonance imaging (MRI) is a noninvasive technique based on the detection of nuclear spin reorientations in a magnetic field, which, however, is relatively insensitive and typically relies on large doses of administered contrast agents to distinguish adequately between normal and diseased tissues. Nanoscale Metal-Organic Frameworks (NMOFs) are combinations of metals and organic molecules on the nanoscale that provide unlimited possibilities for designing task-specific molecules. They are intrinsically biodegradable, and their high porosity makes them ideal for targeted delivery of entrapped agents. They can be specifically targeted to certain regions of the body. In addition to a wealth of applications in other fields, these properties make NMOFs also very suitable for use in biological systems and in particular as more effective contrast agents at lower doses. In addition to Gd carboxylate materials, NMOFs based on Fe, Mn, and Zn were investigated. Coatings such as amorphous silica, biocompatible polymers, and polyoxometalate-peptide hybrid spheres were used to enhance the stability, dispersibility, and biocompatibility of NMOFs. Furthermore, some systems doped with lanthanides were studied as potential multimodal contrast agents.

The in vivo and in vitro effectiveness of these agents has been demonstrated. For example, iron carboxylate NMOFs modified with biocompatible polymers were used for imaging the liver and spleen of Wistar rats. Silica-coated, peptide-targeted Mn NMOFs were shown to be selectively taken up by a human colon cancer cell line in vitro. Finally, a versatile iron carboxylate system post-synthetically modified to contain a fluorophore or a chemotherapeutic showed strong fluorescence upon release from the framework and exhibited cytotoxicity comparable to cisplatin against colon cancer cells.

Author: Wenbin Lin, University of North Carolina, Chapel Hill (USA), www.unc.edu/~wlin/

Title: Nanoscale Metal-Organic Frameworks: Magnetic Resonance Imaging Contrast Agents and Beyond

European Journal of Inorganic Chemistry, Permalink to the article: dx.doi.org/10.1002/ejic.201000496

####

For more information, please click here

Copyright © European Journal of Inorganic Chemistry

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Controlling Dynamic Behavior of Carbon Nanosheets in Structures Made Possible July 30th, 2015

Newly-Developed Polymers Control Size of Nanoparticles during Production Process July 30th, 2015

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Possible Futures

Smaller, faster, cheaper: A new type of modulator for the future of data transmission July 27th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Global Corrosion Resistant Nano Coatings Market To 2015: Acute Market Reports July 27th, 2015

Global Zinc oxide nanopowders Industry 2015: Acute Market Reports July 25th, 2015

Academic/Education

Pakistani Students Who Survived Terror Attack to Attend Weeklong “NanoDiscovery Institute” at SUNY Poly CNSE in Albany July 29th, 2015

Deben reports on the use of their CT500 in the X-ray microtomography laboratory at La Trobe University, Melbourne, Australia July 22nd, 2015

JPK reports on the use of SPM in the Messersmith Group at UC Berkeley looking at biologically inspired polymer adhesives. July 21st, 2015

Renishaw adds Raman analysis to Scanning Electron Microscopy at the University of Sydney, Australia July 9th, 2015

Nanomedicine

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Newly-Developed Polymers Control Size of Nanoparticles during Production Process July 30th, 2015

March 2016; 6th Int'l Conference on Nanostructures in Iran July 29th, 2015

Non-Enzyme Sensor Determines Level of Blood Sugar July 29th, 2015

Announcements

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Controlling Dynamic Behavior of Carbon Nanosheets in Structures Made Possible July 30th, 2015

Newly-Developed Polymers Control Size of Nanoparticles during Production Process July 30th, 2015

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Nanobiotechnology

New computer model could explain how simple molecules took first step toward life: Two Brookhaven researchers developed theoretical model to explain the origins of self-replicating molecules July 28th, 2015

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

Programming adult stem cells to treat muscular dystrophy and more by mimicking nature July 22nd, 2015

Biophotonics - Global Strategic Business Report 2015 July 21st, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project