Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Secret Revealed

Abstract:
The crystal structure of ribose—finally!

Secret Revealed

Weinheim, Germany | Posted on July 8th, 2010

D-Ribose is just a small molecule - but an extremely important one for us life forms. It is astounding that the crystal structure of ribose is not included among the over 500,000 structures that have been solved. After all, ribose is a fundamental building block of ribosomes, the "protein factories" of cells. A Nobel Prize was awarded in 2009 for studies of the structure and function of ribosomes. In the journal Angewandte Chemie, the winners of this prize have just presented a first-hand report of their research. Also in Angewandte Chemie, a team of German and Swiss-based researchers has now presented another long-sought result: they have finally been able to solve the crystal structure of ribose.

Ribose belongs in the chemical class of sugars. Its backbone is a chain of five carbon atoms; four of them carry an OH group, the fifth an oxygen atom attached by a double bond. In most modern textbooks and handbooks, ribose is represented as a â-furanose: four of the carbon atoms and the oxygen atom form a five-membered ring. However, it has been known for over 40 years that in solution, ribose exists as a mixure of four different structures: á- and â-furanoses as well as á- and the dominant â-pyranose. Pyranoses are a form of sugar in which the five carbon atoms and an oxygen atom form a six-membered ring. The prefix á or â indicates whether a specific OH group lies above or below the plane of the ring.

But what form does crystalline ribose adopt? Whereas the structures of other important sugars have been known for a long time, ribose has been reluctant to reveal its secret; the compound is extremely difficult to crystallize. Despite such adverse conditions and countless failed attempts, the team led by Lynne B. McCusker, Beat H Meier, Roland Boese, and Jack D. Dunitz at the ETH Zurich (Switzerland) and the University of Duisburg-Essen have finally succeeded in cracking the structure. By using complex computer calculations, they were first able to obtain meaningful results from X-ray diffraction analyses of powder samples. They were then also able to produce single crystals by zone-melting recrystallization. In this technique, only a small zone of the material is heated and this melt zone is moved. The cooling melt then solidifies with a uniform crystal structure to form the desired single crystal. This can then be examined in by X-ray crystal-structure analysis. Solid-state NMR spectroscopic studies yielded further, complementary information about ribose.

Overall, the researchers came to the realization that D-ribose molecules crystallize as pyranoses, which are six-membered rings. These are present in two crystalline forms that contain â- and á-pyranose in various proportions.

Author: Jack D. Dunitz, Swiss Federal Institute of Technology (ETH) Zurich (Switzerland), www.loc.ethz.ch/people/emerit/dunitz

Title: The Crystal Structure of D-Ribose—At Last!

Angewandte Chemie International Edition 2000, 39, No. 26, 4503-4505, Permalink to the article: dx.doi.org/10.1002/anie.201001266

####

For more information, please click here

Copyright © Angewandte Chemie

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Energy-efficient spin current can be controlled by magnetic field and temperature: SCMR effect simplifies the design of fundamental spintronic components August 20th, 2018

Color effects from transparent 3D printed nanostructures: New design tool automatically creates nanostructure 3D print templates for user-given colors Scientists present work at prestigious SIGGRAPH conference August 18th, 2018

UVA multidisciplinary engineering team designs technology for smart materials: The invention could lead to devices and manufactured goods, such as fabrics, that can dynamically regulate between thermally insulating and cooling August 17th, 2018

Smallest transistor worldwide switches current with a single atom in solid electrolyte: Milestone of energy efficiency in information technology -- Publication in Advanced Materials August 17th, 2018

Chemistry

Flipping the switch on supramolecular electronics August 14th, 2018

Nanoscience and the future of healthcare kick off first day of ACS national meeting in Boston: Presidential events highlight safety, diversity and groundbreaking research August 2nd, 2018

Feds back Rice U. study of nanoscale electrocatalysis: Professors Christy Landes, Stephan Link will analyze mechanisms to improve chemical reactions July 25th, 2018

World-first quantum computer simulation of chemical bonds using trapped ions: Quantum chemistry expected to be one of the first applications of full-scale quantum computers July 25th, 2018

Academic/Education

The Institute of Applied Physics at the University of Tsukuba near Tokyo in Japan uses Deben's ARM2 detector to better understand catalytic reaction mechanisms June 27th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

SUNY Poly Professor Eric Lifshin Selected for ‘Fellow of the Microanalysis Society’ Position for Significant Contributions to Microanalysis June 13th, 2018

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Discoveries

Energy-efficient spin current can be controlled by magnetic field and temperature: SCMR effect simplifies the design of fundamental spintronic components August 20th, 2018

Color effects from transparent 3D printed nanostructures: New design tool automatically creates nanostructure 3D print templates for user-given colors Scientists present work at prestigious SIGGRAPH conference August 18th, 2018

UVA multidisciplinary engineering team designs technology for smart materials: The invention could lead to devices and manufactured goods, such as fabrics, that can dynamically regulate between thermally insulating and cooling August 17th, 2018

Smallest transistor worldwide switches current with a single atom in solid electrolyte: Milestone of energy efficiency in information technology -- Publication in Advanced Materials August 17th, 2018

Announcements

Energy-efficient spin current can be controlled by magnetic field and temperature: SCMR effect simplifies the design of fundamental spintronic components August 20th, 2018

Color effects from transparent 3D printed nanostructures: New design tool automatically creates nanostructure 3D print templates for user-given colors Scientists present work at prestigious SIGGRAPH conference August 18th, 2018

UVA multidisciplinary engineering team designs technology for smart materials: The invention could lead to devices and manufactured goods, such as fabrics, that can dynamically regulate between thermally insulating and cooling August 17th, 2018

Smallest transistor worldwide switches current with a single atom in solid electrolyte: Milestone of energy efficiency in information technology -- Publication in Advanced Materials August 17th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project