Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > K-State research team using nanoscale particles to battle cancer

Abstract:
Forget surgery. One team of Kansas State University researchers is exploring nanoparticle-induced hyperthermia in the battle against cancer.

K-State research team using nanoscale particles to battle cancer

Manhattan, KS | Posted on June 29th, 2010

Since 2007 the team of Deryl Troyer, professor of anatomy and physiology; Viktor Chikan, assistant professor of chemistry; Stefan Bossmann, professor of chemistry; Olga Koper, adjunct professor of chemistry at K-State and vice president of technology and chief technology officer for NanoScale Corporation; and Franklin Kroh, senior scientist at NanoScale Corporation, has been using iron-iron oxide nanoparticles to overheat or bore holes through cancerous tissue to kill it. The nanoparticles are coupled with a diagnostic dye. When the dye is released from the nanoparticle's electronic sphere, it coats other cancerous tissues within the body, making cancer masses easier for medical professionals to detect.

The team is partnered with NanoScale Corporation, a Manhattan company that develops and commercializes advanced materials, products and applications.

Their research, which was explored in mouse models, is currently being reviewed for pre-clinical trials. If accepted, Bossmann said he's optimistic about what it could mean for people with cancer.

"It means within the next decade there is a chance to have an inexpensive cancer treatment with a higher probability of success than chemotherapy," he said. "We have so many drug systems that are outrageously expensive. The typical cancer patient has a million dollars in costs just from the drugs, and this method can be done for about a tenth of the cost.

"Also, our methods are physical methods; cancer cells cannot develop a resistance against physical methods," Bossmann said. "Cancer cells can develop resistance against chemotherapeutics, but they cannot against just being heated to death or having a hole made in them."

While overheating or boring into cancerous cells may sound extreme, the nanoparticles act with orchestrated precision once ingested by the cancer cells, Bossmann said.

Getting the nanoparticles into the cancerous tissue is a lot like fishing, he said.

"We have our fishing pole with the nanoparticles as a very attractive bait that the cancer wants to gobble up -- like a worm is for a fish," he said.

In this case, the bait is a layer of organic material that attracts the cancer to the nanoparticles. The cancer wants the coating for its metabolism. In addition to serving as bait, the organic layer also serves as a cloaking mechanism from the body's defenses, which would otherwise destroy the foreign objects.

Once inside, the nanoparticles -- made with a metal iron core and layered with iron oxide and an organic coating -- go to work. An alternating magnetic field causes the particles to produce friction heat, which is transferred to the cancer cells' surrounding proteins, lipids and water, creating little hotspots. With enough hotspots the tumor cells are heated to death, preserving the healthy tissue, Bossmann said. If the hotspots are not concentrated, the heat destroys the cell's proteins or lipid structures, dissolving the cell membrane. This creates a hole in the tumor and essentially stresses it to death.

"A little stress can push a tumor over the edge," Bossmann said.

The dye within each nanoparticle's electronic sphere is then severed by enzymes and used to check for cancerous masses within the body.

"In the future, someone might be able to develop a blood test because part of these enzymes escape into the bloodsteam. In five years or so, we may be able to draw a blood sample from the patient to see if the patient has cancer, and from the distribution of cancer-related enzymes, what cancer they most likely have," Bossmann said.

While the team has tested the platform only on melanoma and on pancreatic and breast cancer, Bossmann said their technique can be applied to any type of cancer.

The team filed a patent in 2008.

The group's research has been funded by grants from the National Science Foundation, K-State's Terry C. Johnson Center for Basic Cancer Research and the National Institutes of Health/Small Business Innovation Research.

####

For more information, please click here

Contacts:
Source: Stefan Bossmann, 785-532-6817,

Contact or 785-532-2535

News release prepared by: Greg Tammen, 785-532-2535,

Copyright © Kansas State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Possible Futures

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Academic/Education

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Moving at the Speed of Light: University of Arizona selected for high-impact, industrial demonstration of new integrated photonic cryogenic datalink for focal plane arrays: Program is major milestone for AIM Photonics August 10th, 2017

Graduate Students from Across the Country Attend Hands-on NanoCamp: Prominent scientists Warren Oliver, Ph.D., and George Pharr, Ph.D., presented a weeklong NanoCamp for hand-picked graduate students across the United States July 26th, 2017

The Physics Department of Imperial College, London, uses the Quorum Q150T to deposit metals and ITO to make plasmonic sensors and electric contact pads July 13th, 2017

Nanomedicine

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Tokai University research: Nanomaterial wrap for improved tissue imaging August 21st, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Announcements

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Patents/IP/Tech Transfer/Licensing

Argonne National Laboratory’s Continuous ALD Technology Licensed Exclusively to Forge Nano July 7th, 2017

Aculon Expands NanoProof® Product Line for Electronics Waterproofing Technology: With growing market opportunities Aculon Launches NanoProof® 8 with Push Through Connectivity™ and NanoProof® DAB a syringe application May 30th, 2017

NREL’s Advanced Atomic Layer Deposition Enables Lithium-Ion Battery Technology: May 10th, 2017

Forge Nano 2017: 1st Quarter Media Update April 20th, 2017

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

2-faced 2-D material is a first at Rice: Rice University materials scientists create flat sandwich of sulfur, molybdenum and selenium August 14th, 2017

Nanobiotechnology

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Tokai University research: Nanomaterial wrap for improved tissue imaging August 21st, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project