Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > K-State research team using nanoscale particles to battle cancer

Abstract:
Forget surgery. One team of Kansas State University researchers is exploring nanoparticle-induced hyperthermia in the battle against cancer.

K-State research team using nanoscale particles to battle cancer

Manhattan, KS | Posted on June 29th, 2010

Since 2007 the team of Deryl Troyer, professor of anatomy and physiology; Viktor Chikan, assistant professor of chemistry; Stefan Bossmann, professor of chemistry; Olga Koper, adjunct professor of chemistry at K-State and vice president of technology and chief technology officer for NanoScale Corporation; and Franklin Kroh, senior scientist at NanoScale Corporation, has been using iron-iron oxide nanoparticles to overheat or bore holes through cancerous tissue to kill it. The nanoparticles are coupled with a diagnostic dye. When the dye is released from the nanoparticle's electronic sphere, it coats other cancerous tissues within the body, making cancer masses easier for medical professionals to detect.

The team is partnered with NanoScale Corporation, a Manhattan company that develops and commercializes advanced materials, products and applications.

Their research, which was explored in mouse models, is currently being reviewed for pre-clinical trials. If accepted, Bossmann said he's optimistic about what it could mean for people with cancer.

"It means within the next decade there is a chance to have an inexpensive cancer treatment with a higher probability of success than chemotherapy," he said. "We have so many drug systems that are outrageously expensive. The typical cancer patient has a million dollars in costs just from the drugs, and this method can be done for about a tenth of the cost.

"Also, our methods are physical methods; cancer cells cannot develop a resistance against physical methods," Bossmann said. "Cancer cells can develop resistance against chemotherapeutics, but they cannot against just being heated to death or having a hole made in them."

While overheating or boring into cancerous cells may sound extreme, the nanoparticles act with orchestrated precision once ingested by the cancer cells, Bossmann said.

Getting the nanoparticles into the cancerous tissue is a lot like fishing, he said.

"We have our fishing pole with the nanoparticles as a very attractive bait that the cancer wants to gobble up -- like a worm is for a fish," he said.

In this case, the bait is a layer of organic material that attracts the cancer to the nanoparticles. The cancer wants the coating for its metabolism. In addition to serving as bait, the organic layer also serves as a cloaking mechanism from the body's defenses, which would otherwise destroy the foreign objects.

Once inside, the nanoparticles -- made with a metal iron core and layered with iron oxide and an organic coating -- go to work. An alternating magnetic field causes the particles to produce friction heat, which is transferred to the cancer cells' surrounding proteins, lipids and water, creating little hotspots. With enough hotspots the tumor cells are heated to death, preserving the healthy tissue, Bossmann said. If the hotspots are not concentrated, the heat destroys the cell's proteins or lipid structures, dissolving the cell membrane. This creates a hole in the tumor and essentially stresses it to death.

"A little stress can push a tumor over the edge," Bossmann said.

The dye within each nanoparticle's electronic sphere is then severed by enzymes and used to check for cancerous masses within the body.

"In the future, someone might be able to develop a blood test because part of these enzymes escape into the bloodsteam. In five years or so, we may be able to draw a blood sample from the patient to see if the patient has cancer, and from the distribution of cancer-related enzymes, what cancer they most likely have," Bossmann said.

While the team has tested the platform only on melanoma and on pancreatic and breast cancer, Bossmann said their technique can be applied to any type of cancer.

The team filed a patent in 2008.

The group's research has been funded by grants from the National Science Foundation, K-State's Terry C. Johnson Center for Basic Cancer Research and the National Institutes of Health/Small Business Innovation Research.

####

For more information, please click here

Contacts:
Source: Stefan Bossmann, 785-532-6817,

Contact or 785-532-2535

News release prepared by: Greg Tammen, 785-532-2535,

Copyright © Kansas State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Spintronics for future information technologies: Spin currents in topological insulators controlled May 2nd, 2016

Possible Futures

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Academic/Education

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

The Ottawa Hospital Research Institute uses the ZetaView from Particle Metrix to study membrane microparticles as potential biomarkers for underlying diseases April 12th, 2016

FEI Partners with Five Pharmaceutical Companies, the Medical Research Council and the University of Cambridge to form Cryo-EM Research Consortium April 5th, 2016

SUNY Poly, in Collaboration with the George Washington School of Medicine and Health Sciences and Stony Brook University, Demonstrates Pioneering Method to Visualize and Identify Engineered Nanoparticles in Tissue March 25th, 2016

Nanomedicine

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Announcements

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Spintronics for future information technologies: Spin currents in topological insulators controlled May 2nd, 2016

Patents/IP/Tech Transfer/Licensing

System creates on-demand 'nanotube forests,' has potential industry applications April 20th, 2016

Smaller. Cheaper. Better. Iron nitride transformers developed at Sandia could boost energy storage options March 28th, 2016

Correction: Solar fuels: Protective layer for the 'artificial leaf' March 22nd, 2016

New nanoparticle technology to decipher structure and function of membrane proteins March 9th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Brookhaven's Oleg Gang Named a Battelle 'Inventor of the Year': Recognized for work using DNA to guide and regulate the self-assembly of nanoparticles into clusters and arrays with controllable properties April 25th, 2016

Zip software can detect the quantum-classical boundary: Compression of experimental data reveals the presence of quantum correlations April 21st, 2016

Making electronics out of coal: Instead of burning up this complex hydrocarbon, let's make devices from it April 20th, 2016

Nano-magnets produce 3-dimensional images: Wide-view 3-dimensional holographic display composed of nano-magnetic pixels April 20th, 2016

Nanobiotechnology

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic