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Home > Press > Imec reports asymmetric nanostructures for early and more accurate prediction of cancer

Abstract:
Researchers at the nanotechnology research centre imec (Leuven, Belgium) have demonstrated biosensors based on novel nanostructure geometries that increase the sensitivity and allow to detect extremely low concentrations of specific disease markers. This paves the way to early diagnostics of for example cancer by detecting low densities of cancer markers in human blood samples.

Imec reports asymmetric nanostructures for early and more accurate prediction of cancer

Tech Connect World, Anaheim, CA | Posted on June 24th, 2010

Functionalized nanoparticles can identify and measure extremely low concentrations of specific molecules. They enable the realization of diagnostic systems with increased sensitivity, specificity and reliability resulting in a better and more cost-efficient healthcare. And, going one step further, functionalized nanoparticles can help treat diseases, by destroying the diseased cells that the nanoparticles bind to.

Imec aims at developing biosensor systems exploiting a phenomenon known as localized surface plasmon resonance in noble metal (e.g. gold and silver) nanostructures. The biosensors are based on optical detection of a change in spectral response of the nanostructures upon binding a disease marker. The detection sensitivity can be increased by changing the morphology and size of the noble metal nanostructures. The biosensor system is cheap and easily extendable to multiparameter biosensing. Imec today presents broken symmetry gold nanostructures that combine nanorings with nanodiscs. Combining different nanostructures in close proximity allows detailed engineering of the plasmon resonance of the nanostructures. More specifically, imec targeted an optimization of both the width of the resonance peak and the resonance shift upon binding of the disease marker. With respect to these parameters, the new geometries clearly outperform the traditional nanospheres. Therefore, they are better suited for practical use in sensitive biosensor systems.

"With our bio-nano research, we aim at playing an important role in developing powerful healthcare diagnostics and therapy. We work on innovative instruments to support the research into diseases and we look into portable technologies that can diagnose diseases at an early stage. We want to help the pharmaceutical and diagnostic industry with instruments to develop diagnostic tests and therapies more efficiently" said Prof. Liesbet Lagae, program manager HUMAN++ on biomolecular interfacing technology.

Some of these results were achieved in collaboration with the Catholic University of Leuven (Leuven, Belgium), Imperial College (London, UK) and Rice University (Houston, Texas).

####

About imec
Imec performs world-leading research in nano-electronics. Imec leverages its scientific knowledge with the innovative power of its global partnerships in ICT, healthcare and energy. Imec delivers industry-relevant technology solutions. In a unique high-tech environment, its international top talent is committed to providing the building blocks for a better life in a sustainable society.

Imec is headquartered in Leuven, Belgium, and has offices in Belgium, the Netherlands, Taiwan, US, China and Japan. Its staff of more than 1,750 people includes over 550 industrial residents and guest researchers. In 2009, imec's revenue (P&L) was 275 million euro.

Further information on imec can be found at www.imec.be

Imec is a registered trademark for the activities of IMEC International (a legal entity set up under Belgian law as a "stichting van openbaar nut”), imec Belgium (imec vzw supported by the Flemish Government), imec the Netherlands (Stichting imec Nederland, part of Holst Centre which is supported by the Dutch Government) and imec Taiwan (imec Taiwan Co.).

For more information, please click here

Contacts:
Katrien Marent, Director of External Communications, T: +32 16 28 18 80, Mobile: +32 474 30 28 66,

Barbara Kalkis, Maestro Marketing & PR, T: +1 408 996 9975,

Copyright © imec

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