Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Celator® Pharmaceuticals Presents Data

Abstract:
Celator® Pharmaceuticals Presents Data on Combining CPX-351 With Clofarabine or Azacytidine at the European Hematology Association Congress

Celator® Pharmaceuticals Presents Data

Princeton, NJ | Posted on June 14th, 2010

Celator Pharmaceuticals today announced that new data from a preclinical leukemia study in mice demonstrate that its lead product, CPX-351 (Cytarabine:Daunorubicin) Liposome Injection, alone or in combination with clofarabine or azacytidine can improve treatment outcomes compared to the combination of either agent with the conventional (unencapsulated) cytarabine:daunorubicin regimen. The results were presented at the 15th Congress of the European Hematology Association in Barcelona, Spain, June 10-13, 2010 (Abstract #718(1)).

"As prior research has demonstrated, the challenge of combining cytarabine:daunorubicin with other anti-leukemic agents is that the dosing adjustments necessary to avoid unacceptable toxicities may compromise treatment efficacy," said Lawrence Mayer, PhD, president and head of research at Celator Pharmaceuticals. "The results from this model demonstrate the enhanced efficacy and wider therapeutic window of CPX-351 compared to the conventional cytarabine:daunorubicin regimen."

The study was conducted in a human leukemia xenograft model (CCRF-CEM mice). Tumor-bearing mice were treated with either clofarabine or azacytidine alone or with one of these agents in combination with CPX-351 or a conventional cytarabine:daunorubicin regimen. Maximum tolerated dose assessments were made for clofarabine and azacytidine singly, and in both combinations. The dose of CPX-351 had to be reduced by 50 percent when combined with either agent to avoid mortality or unacceptable weight loss. The dose of conventional cytarabine:daunorubicin had to be reduced by 50 percent when combined with clofarabine and by 75 percent when combined with azacytidine.

Prolongation of median survival relative to treatment with the individual agents, the principle efficacy outcome, was substantially greater for CPX-351 alone and for CPX-351 in combination with either agent. CPX-351 alone resulted in a greater median survival than conventional cytarabine:daunorubicin, single agent clofarabine or single agent azacytidine, or the combination of conventional cytarabine:daunorubicin with either clofarabine or azacytidine. CPX-351 in combination with either clofarabine or azacytidine produced the longest median survival.

"CPX-351 has potent anti-leukemia activity alone and in combination with other drugs in development for the treatment of leukemia," said Scott Jackson, chief executive officer of Celator Pharmaceuticals. "Based on the positive results generated with CPX-351 in patients with acute myeloid leukemia, the Company is evaluating the product's potential for the treatment of other hematologic malignancies."

About CPX-351

CPX-351 (Cytarabine:Daunorubicin) Liposome Injection represents a new approach to developing combinations of drugs in which drug molar ratios with synergistic anti-tumor activity are encapsulated in a drug delivery vehicle in order to maintain the desired ratio following administration. CPX-351 has been granted orphan drug status by the U.S. Food & Drug Administration (FDA) for the treatment of acute myeloid leukemia (AML). Celator is currently conducting two randomized phase 2 studies with CPX-351 for the treatment of AML. The first randomized phase 2 study compares CPX-351 versus the standard "7+3" regimen of cytarabine:daunorubicin in patients 60 years of age up to and including 75 years of age with newly diagnosed AML. Celator recently reported topline data from this study. The primary efficacy endpoint of the study, the rate of patients achieving a complete remission with CPX-351 compared to "7+3," achieved statistical significance. In addition, the Company reported a reduction in the 30-day and 60-day mortality with CPX-351 versus the "7+3" regimen. The primary efficacy endpoint analysis, and additional results from this study, will be submitted to a major medical conference in 2010. The second randomized phase 2 study is comparing CPX-351 versus intensive salvage therapy in patients 18 years of age up to and including 65 years of age with AML in first relapse. Enrollment is expected to be completed in 2010. This study is supported by The Leukemia & Lymphoma Society.

(1) EHA Abstract #718: Fan M, Mayer L, Udechukwu T, et al. Preclinical evaluation of CPX-351 liposome injection in combination with clofarabine and azacytidine. Poster presented June 11, 2010.

####

About Celator
Celator Pharmaceuticals, Inc., with locations in Princeton, NJ, and Vancouver, BC, is a privately held pharmaceutical company developing new and more effective therapies to treat cancer. CombiPlex®, the company's proprietary drug ratio technology platform, represents a novel approach that identifies molar ratios of drugs that will deliver a synergistic benefit, and locks the desired ratio in a nano-scale drug delivery vehicle that maintains the ratio in patients with the goal of improving clinical outcomes. The company pipeline includes two phase 2 products; CPX-351 (a liposomal formulation of cytarabine:daunorubicin) for the treatment of acute myeloid leukemia and CPX-1 (a liposomal formulation of irinotecan:floxuridine) for the treatment of colorectal cancer; a preclinical stage compound, CPX-571 (a liposomal formulation of irinotecan:cisplatin); and multiple research programs, including the hydrophobic docetaxel prodrug nanoparticle (HDPN) formulation being studied by the National Cancer Institute's Nanotechnology Characterization Laboratory. Based on the applications of CombiPlex and the proprietary nanoparticle prodrug delivery platform, Celator is positioned to advance a broad pipeline of cancer therapies involving both previously approved and novel drug agents. For more information, please visit the company's website at www.celatorpharma.com. Information on ongoing trials is available at www.clinicaltrials.gov.

For more information, please click here

Copyright © PrNewswire

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

Possible Futures

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Atomic imperfections move quantum communication network closer to reality June 25th, 2017

Research accelerates quest for quicker, longer-lasting electronics: UC Riverside-led research makes topological insulators magnetic well above room temperatures June 25th, 2017

U.S. Air Force Research Lab Taps IBM to Build Brain-Inspired AI Supercomputing System: Equal to 64 million neurons, new neurosynaptic supercomputing system will power complex AI tasks at unprecedented speed and energy efficiency June 23rd, 2017

Nanomedicine

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Researchers developed nanoparticle based contrast agent for dual modal imaging of cancer June 21st, 2017

Learning with light: New system allows optical “deep learning”: Neural networks could be implemented more quickly using new photonic technology June 12th, 2017

Mussels add muscle to biocompatible fibers: Rice University chemists develop hydrogel strings using compound found in sea creatures June 9th, 2017

Announcements

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

Nanobiotechnology

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Researchers developed nanoparticle based contrast agent for dual modal imaging of cancer June 21st, 2017

Mussels add muscle to biocompatible fibers: Rice University chemists develop hydrogel strings using compound found in sea creatures June 9th, 2017

Making vessels leaky on demand could aid drug delivery:Rice University scientists use magnets and nanoparticles to open, close gaps in blood vessels June 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project