Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > A new study shows that silver nanoparticles mitigate the cell damage caused by ethanol

The top left image shows the actin cytoskeleton of the control astrocytes; on the right, cells exposed to ethanol, showing alterations to both the cell morphology and the actin cytoskeleton. The bottom images show the effects of applying silver nanoparticles; on the right, the ethanol causes no alteration of the actin cytoskeleton
The top left image shows the actin cytoskeleton of the control astrocytes; on the right, cells exposed to ethanol, showing alterations to both the cell morphology and the actin cytoskeleton. The bottom images show the effects of applying silver nanoparticles; on the right, the ethanol causes no alteration of the actin cytoskeleton

Abstract:
The cover story of the most recent edition of the Journal of the American Chemical Society (JACS) describes how nanoparticles formed by very small numbers of silver atoms can protect against the cell damage caused by ethanol. The study was led by researchers from the University of Barcelona and conducted in conjunction with the Magnetism and Nanotechnology laboratory of the University of Santiago de Compostela.

A new study shows that silver nanoparticles mitigate the cell damage caused by ethanol

Barcelona, Spain | Posted on May 26th, 2010

"The results of the study show that these clusters of small numbers of silver atoms catalyze ethanol oxidation at similar concentrations to those found in the blood of alcoholics and at values of membrane potential and pH that are compatible with those exhibited by mammalian cells", explains Gustavo Egea, a professor with the Department of Cell Biology, Immunology and Neurosciences of the Faculty of Medicine at the UB and an affiliated researcher for the Institute of Nanosciences and Nanotechnology (IN2UB) and the August Pi i Sunyer Miomedical Research Institute (IDIBAPS).

Researchers applied the silver nanoparticles to astrocytes exposed to ethanol. These types of cells accompany neurons and are widely used as models for studying the physiopathological mechanisms of alcohol in foetal alcohol syndrome, a disease that develops in some unborn babies when the mother consumes excessive levels of alcohol and which leads to a range of severe neurological disorders.

Alcohol has particularly harmful effects on nerve cells, and in the specific case of astrocytes it induces programmed cell-death and an alteration of the actin cytoskeleton. Following application of the silver nanoparticles to ethanol-exposed cells, the actin cytoskeleton shows marked improvements and cell-death does not occur. "So, the harmful effect of ethanol on astrocytes is mitigated by the silver nanoparticles, which act as a cytoprotective agent", explains Javier Selva, a lecturer with the Department of Cell Biology, Immunology and Neuroscience and first author of the paper.

The study combines analysis of the electrocatalytic properties of silver nanoparticles with examination of their potential biological applications. "This is a promising field in electrochemistry applied to cell biology, which harnesses the different properties of nanoparticles formed by very small numbers of atoms, referred to generically as atomic clusters", explains Gustavo Egea.

The authors have also found that the nanoparticles prevent alterations induced by other primary alcohols such as methanol and butanol, although not those induced by other toxins such as hydrogen peroxide.




Further information:

Silver sub-nanoclusters electrocatalyze ethanol oxidation and provide protection against ethanol toxicity in cultured mammalian cells. Javier Selva, Susana E. Martínez, David Buceta, María Rodríguez-Vázquez, M. Carmen Blanco, M. Arturo López-Quintela and Gustavo Egea. Journal of the American Chemical Society. DOI: 10.1021/ja907988s - pubs.acs.org/doi/abs/10.1021/ja907988s

####

For more information, please click here

Copyright © University of Barcelona

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

Possible Futures

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

Academic/Education

SUNY Polytechnic Institute Announces Total of 172 Teams Selected to Compete in Solar in Your Community Challenge: Teams from 40 states, plus Washington, DC, 2 Territories, and 4 American Indian Reservations, Will Deploy Solar in Underserved Communities April 20th, 2017

Rice crew revved for Nanocar Race: Nanocar creator James Tour and team take on international competition with single-molecule marvel April 20th, 2017

The Catholic University of Rome uses the JPK NanoWizard® AFM & CellHesion® systems to understand how cells sense and respond to mechanical stimuli April 5th, 2017

AIM Photonics Welcomes Coventor as Newest Member: US-Backed Initiative Taps Process Modeling Specialist to Enable Manufacturing of High-Yield, High-Performance Integrated Photonic Designs March 16th, 2017

Nanomedicine

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Nanotubes that build themselves April 14th, 2017

Announcements

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

Nanobiotechnology

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Nanotubes that build themselves April 14th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project