Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Potential for New Nanoparticle-Based Cancer Detection

Abstract:
Recent studies support the idea that the standard methods of screening men for prostate cancer leave much to be desired, particularly in terms of their inability to have much effect on prostate cancer survival. Now, a team of investigators at the University of Missouri School of Medicine have created a targeted gold nanoparticle that appears to offer a more sensitive and accurate method for detecting early stage prostate cancer. These nanoparticles may also be useful for detecting lung and breast cancers, too.

Potential for New Nanoparticle-Based Cancer Detection

Bethesda, MD | Posted on May 22nd, 2010

The investigators, led by Raghuraman Kannan and Kattesh Katti, published the results of their studies in the Proceedings of the National Academy of Sciences. Dr. Katti is the principal investigator of a National Cancer Institute Cancer Nanotechnology Platform Partnership.

Drs. Kannan and Katti and their colleagues created their potential imaging agent by coating gold nanoparticles with bombesin, also known as Gastrin Release Peptide (GRP), a naturally occurring molecule that binds to a specific receptor that is abundant on prostate, breast, and small cell lung cancer cells. To do so, they had to develop new synthetic methods for linking this peptide, as well as other related peptides, to the gold nanoparticles.

With the nanoparticles in hand, the research team used them to image prostate tumors growing in mice. These experiments demonstrated that the nanoparticles were very specific at binding to prostate tumors and that this binding enabled the tumors to be spotted easily using computed tomography x-ray imaging. Moreover, tumors took up approximately 10 times more of the targeted nanoparticles than bombesin linked directly to the radioactive element technetium, a construct now in clinical trials as an imaging agent. These experiments also showed that injecting the nanoparticles into the peritoneal cavity produced better results than when the nanoparticles were injected directly into the blood stream, in large part because fewer nanoparticles became trapped in the liver and spleen.

This work, which is detailed in a paper titled, "Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity," was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Regulation of two-dimensional nanomaterials: New driving force for lithium-ion batteries July 26th, 2017

Liquid electrolyte contacts for advanced characterization of resistive switching memories July 26th, 2017

Phenom-World Launches Phenom Pro and ProX Generation 5 SEMs at Microscopy & Microanalysis Conference USA: The excellent performance in a wide range of applications offers a serious alternative to floor model SEMs July 26th, 2017

Graduate Students from Across the Country Attend Hands-on NanoCamp: Prominent scientists Warren Oliver, Ph.D., and George Pharr, Ph.D., presented a weeklong NanoCamp for hand-picked graduate students across the United States July 26th, 2017

Possible Futures

Regulation of two-dimensional nanomaterials: New driving force for lithium-ion batteries July 26th, 2017

Liquid electrolyte contacts for advanced characterization of resistive switching memories July 26th, 2017

Graduate Students from Across the Country Attend Hands-on NanoCamp: Prominent scientists Warren Oliver, Ph.D., and George Pharr, Ph.D., presented a weeklong NanoCamp for hand-picked graduate students across the United States July 26th, 2017

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Academic/Education

Graduate Students from Across the Country Attend Hands-on NanoCamp: Prominent scientists Warren Oliver, Ph.D., and George Pharr, Ph.D., presented a weeklong NanoCamp for hand-picked graduate students across the United States July 26th, 2017

The Physics Department of Imperial College, London, uses the Quorum Q150T to deposit metals and ITO to make plasmonic sensors and electric contact pads July 13th, 2017

Oxford Instruments congratulates Lancaster University for inaugurating the IsoLab, built for studying quantum systems June 20th, 2017

The 2017 Winners for Generation Nano June 8th, 2017

Nanomedicine

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Announcements

Regulation of two-dimensional nanomaterials: New driving force for lithium-ion batteries July 26th, 2017

Liquid electrolyte contacts for advanced characterization of resistive switching memories July 26th, 2017

Phenom-World Launches Phenom Pro and ProX Generation 5 SEMs at Microscopy & Microanalysis Conference USA: The excellent performance in a wide range of applications offers a serious alternative to floor model SEMs July 26th, 2017

Graduate Students from Across the Country Attend Hands-on NanoCamp: Prominent scientists Warren Oliver, Ph.D., and George Pharr, Ph.D., presented a weeklong NanoCamp for hand-picked graduate students across the United States July 26th, 2017

Nanobiotechnology

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Researchers revolutionize vital conservation tool with use of gold nanotechnology and lasers: Cryopreservation study results have sweeping implications for wildlife conservation and human health July 15th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project