Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > NanoVir, LLC Receives $3M Preclinical Development NIAID Grant

Abstract:
The National Institute of Allergy and Infectious Diseases (NIAID), an institute within the National Institutes of Health (NIH), has awarded a nearly $3 million small Business Technology Transfer Research (STTR) grant to NanoVir, LLC to support synthesis and pre-clinical development of lead antiviral compounds for treatment of human papillomavirus 16 (HPV16).

NanoVir, LLC Receives $3M Preclinical Development NIAID Grant

Kalamazoo, MI | Posted on May 5th, 2010

The grant to NanoVir, which spans three years, will support work at several collaborating institutions including NanoVir, the University of Missouri-St. Louis and Stanford Research Institute-International.

HPV16 is by far the major cause of cervical dysplasia and cancer. Currently, no effective treatment for the virus is available or anticipated. Centers for Disease Control and the World Health Organization typically refer to "follow up" observation and surgical intervention as the only options available for women infected by HPV16. Their reports rarely even suggest that antivirals might soon provide hope for treatment.

The STTR grant from the NIAID will support preclinical development of antiviral compounds, discovered and designed by NanoVir scientists, which possess excellent potency for treatment of HPV16 in human cell culture. These compounds, which target the HPV origin of replication (ori), a DNA regulatory region within the HPV genome, were designed, synthesized and tested with the support of a previous NIAID-AT-STTR Phase 1 grant awarded to NanoVir by the NIAID. They hold considerable potential as antiviral agents that have the potential to add an important tool to complement the HPV vaccines and allow both HPV+ and HPV- patients to be treated.

"This Phase 2 award will allow us to initiate the chemical scale-up and safety studies required by the Food and Drug Administration before clinical trials can be initiated. We're honored to have been awarded this grant, especially at a time when the peer-review and competition for such awards is so stringent," said Chris Fisher, co-founder and Director of Biology of NanoVir. "This is a significant validation of our approach and I believe that, as long as we hit our milestones, we will soon be in a position to enter clinical trials in HPV-positive women."

NanoVir, LLC is a Michigan-based company whose headquarters are located at the Southwest Michigan Innovation Center in Kalamazoo, Michigan. NanoVir is working on prevention of cervical cancer by developing antiviral agents for HPV, the cause of the vast majority of cervical cancer. The company is funded by the National Institutes of Health, under the National Institute of Allergy and Infectious Diseases.

####

About NanoVir
NanoVir, LLC is a drug discovery company dedicated to finding treatments for HPV, a primary cause of both abnormal pap smears and cervical cancer. NanoVir focuses on studying DNA-targeted therapies aimed to treat high-risk HPV infection before it can progress to cancer. NanoVir’s Kalamazoo site at the Southwest Michigan Innovation Center of Western Michigan University conducts cell-biology and virology studies, while its colleagues at the University of Missouri-St. Louis site carry out the related chemistry. The firm is currently concentrating on a topical treatment that could eliminate HPV infections.

About the Southwest Michigan Innovation Center
The Southwest Michigan Innovation Center is a 58,000-square-foot incubator/accelerator that provides wet-lab space, access to venture funding and comprehensive business support services to emerging companies in the life science industry. The Innovation Center is a state-of-the-art facility designed and staffed with high-tech scientific companies in mind. For more information, visit www.kazoosmic.com.

For more information, please click here

Contacts:
Send general inquires to:

Dr. Chris Fisher
NanoVir
4717 Campus Dr.
Kalamazoo, MI 49008
269.372.3261 office
269.372.3397 fax

Copyright © NanoVir

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Australian startup creates world’s first 100% cotton hydrophobic T-Shirts November 26th, 2014

The mysterious 'action at a distance' between liquid containers November 26th, 2014

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

Lawrence Livermore researchers develop efficient method to produce nanoporous metals November 25th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Lawrence Livermore researchers develop efficient method to produce nanoporous metals November 25th, 2014

Renishaw receives Queen's Award for spectroscopy developments November 25th, 2014

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Nanomedicine

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Announcements

Australian startup creates world’s first 100% cotton hydrophobic T-Shirts November 26th, 2014

The mysterious 'action at a distance' between liquid containers November 26th, 2014

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Renishaw receives Queen's Award for spectroscopy developments November 25th, 2014

A*STAR SIMTech wins international award for breaking new ground in actuators: SIMTech invention can be used in an array of industries, and is critical for next generation ultra-precision systems November 24th, 2014

SUNY Poly Student Awarded Fellowship with the U.S. Department of Energy's Postgraduate Research Program: Ph.D. Candidate Accepts Postmaster's Appointment To Conduct Research At Albany NanoTech Complex November 13th, 2014

MEMS Industry Group's 10th Annual Executive Conference Showcases Rapid Innovation in MEMS/Sensors: Emphasizes Spirit of Collaboration, Supporting First Open-Source Algorithm Community, New Standardization Efforts November 10th, 2014

Nanobiotechnology

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Implementation of DNA Chains in Designing Nanospin Pieces November 9th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE