Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanotechnology Helps Illuminate Activation Process of T-Cells

Abstract:
Scientists took a major step forward in understanding how T-cells are activated in the course of an immune response by combining nanotechnology and cell biology. T-cells are the all important trigger that starts the human body's response to infection.

Nanotechnology Helps Illuminate Activation Process of T-Cells

Alberta, Canada | Posted on May 3rd, 2010

Christopher Cairo and his team at the University of Alberta are studying how one critical trigger for the body's T-cell response is switched on. Cairo looked at the molecule known as CD45 and its function in T-cells. The activation of CD45 is part of a chain of events that allows the body to produce T cells that target an infection and, just as importantly, shut down overactive T cells that could lead to damage.

Cairo and his team are using nanotechnology to study how individual molecules interact in live cells. The method allows them to view the movement of these molecules at nanometer scale, so they can "see" the molecular interaction. To see the movement of a protein, researchers labeled the molecules with nanoparticles and then observed the particles using a microscope. This study is the first to analyze CD45 this way, but the most important advance is their observation of how CD45 interacts with other molecules in the cell to carry out its function.

The team found that CD45 is tethered to the cell cytoskeleton, a meshwork of proteins that gives the cell its shape and structure. They also observed how particular proteins hold CD45 onto the cytoskeleton.

"It's one thing to observe molecular binding in a test tube," said Cairo. "It's quite another to see how the process happens in a live cell." Cairo said a better understanding of the immune regulator CD45 could eventually lead researchers to a point where they can use it as a way to control T cells.

"You could imagine that if you knew when CD45 was turned on or how each molecular partner helps it work, you might be able to take advantage of that and design an inhibitor," said Cairo. "Of course, that's a long way off; at this point, we're trying to understand the molecular mechanisms involved."

The study was a multidisciplinary effort. In addition to the Cairo group at the U of A, teams led by mathematician Dan Coombs (University of British Columbia), biochemist Jon Morrow (Yale University Medical School) and biophysicist David Golan (Harvard Medical School) all contributed to the study.

####

For more information, please click here

Copyright © FARS

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Elusive Quantum Transformations Found Near Absolute Zero: Brookhaven Lab and Stony Brook University researchers measured the quantum fluctuations behind a novel magnetic material's ultra-cold ferromagnetic phase transition September 15th, 2014

Nanomedicine

Treatment of Cell Infection by Nanotechnology September 15th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

Iranian Scientists Discover Nanotechnology Method to Remove Limitations in Tumor Surgery September 11th, 2014

Iranian Nanotechnology Scientists Produce Polymeric Scaffolds for Tissue Engineering September 11th, 2014

Announcements

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Nanobiotechnology

NanoStruck has a High Recovery Rate on Mine Tailings: retrieval of up to 96% of Gold, 88% of Silver and 86% of Palladium September 12th, 2014

Boosting armor for nuclear-waste eating microbes September 12th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE