Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanotechnology Helps Illuminate Activation Process of T-Cells

Abstract:
Scientists took a major step forward in understanding how T-cells are activated in the course of an immune response by combining nanotechnology and cell biology. T-cells are the all important trigger that starts the human body's response to infection.

Nanotechnology Helps Illuminate Activation Process of T-Cells

Alberta, Canada | Posted on May 3rd, 2010

Christopher Cairo and his team at the University of Alberta are studying how one critical trigger for the body's T-cell response is switched on. Cairo looked at the molecule known as CD45 and its function in T-cells. The activation of CD45 is part of a chain of events that allows the body to produce T cells that target an infection and, just as importantly, shut down overactive T cells that could lead to damage.

Cairo and his team are using nanotechnology to study how individual molecules interact in live cells. The method allows them to view the movement of these molecules at nanometer scale, so they can "see" the molecular interaction. To see the movement of a protein, researchers labeled the molecules with nanoparticles and then observed the particles using a microscope. This study is the first to analyze CD45 this way, but the most important advance is their observation of how CD45 interacts with other molecules in the cell to carry out its function.

The team found that CD45 is tethered to the cell cytoskeleton, a meshwork of proteins that gives the cell its shape and structure. They also observed how particular proteins hold CD45 onto the cytoskeleton.

"It's one thing to observe molecular binding in a test tube," said Cairo. "It's quite another to see how the process happens in a live cell." Cairo said a better understanding of the immune regulator CD45 could eventually lead researchers to a point where they can use it as a way to control T cells.

"You could imagine that if you knew when CD45 was turned on or how each molecular partner helps it work, you might be able to take advantage of that and design an inhibitor," said Cairo. "Of course, that's a long way off; at this point, we're trying to understand the molecular mechanisms involved."

The study was a multidisciplinary effort. In addition to the Cairo group at the U of A, teams led by mathematician Dan Coombs (University of British Columbia), biochemist Jon Morrow (Yale University Medical School) and biophysicist David Golan (Harvard Medical School) all contributed to the study.

####

For more information, please click here

Copyright © FARS

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Conversion of Greenhouse Gases to Syngas in Presence of Nanocatalysts in Iran May 22nd, 2015

New Antibacterial Wound Dressing in Iran Can Display Replacement Time May 22nd, 2015

Haydale Named Lead Sponsor for Cambridge Graphene Festival May 22nd, 2015

Simulations predict flat liquid May 21st, 2015

Nanomedicine

New Antibacterial Wound Dressing in Iran Can Display Replacement Time May 22nd, 2015

Researchers develop new way to manufacture nanofibers May 21st, 2015

Effective Nano-Micelles Designed in Iran to Treat Cancer May 20th, 2015

Nature inspires first artificial molecular pump: Simple design mimics pumping mechanism of life-sustaining proteins found in living cells May 19th, 2015

Announcements

Conversion of Greenhouse Gases to Syngas in Presence of Nanocatalysts in Iran May 22nd, 2015

New Antibacterial Wound Dressing in Iran Can Display Replacement Time May 22nd, 2015

Haydale Named Lead Sponsor for Cambridge Graphene Festival May 22nd, 2015

INSIDDE: Uncovering the real history of art using a graphene scanner May 21st, 2015

Nanobiotechnology

Supercomputer unlocks secrets of plant cells to pave the way for more resilient crops: IBM partners with University of Melbourne and UQ May 21st, 2015

Researchers develop new way to manufacture nanofibers May 21st, 2015

Nature inspires first artificial molecular pump: Simple design mimics pumping mechanism of life-sustaining proteins found in living cells May 19th, 2015

Studying dynamics of ion channels May 18th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project