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Home > News > Surface chemistry helps direct stem cell fate

May 2nd, 2010

Surface chemistry helps direct stem cell fate

Abstract:
UK scientists have developed a method to control the behaviour and fate of stem cells using chemically-defined nanopatterned surfaces. This could aid development of tissues and organs for transplants.

The team, led by John Hunt and Judith Curran at the University of Liverpool, use a technique known as dip pen nanolithography to precisely and homogenously pattern a planar gold surface with nanodots coated with simple functional groups, such as carboxyl, amino, methyl, and hydroxyl groups. Mesenchymal stem cells were then cultured on these surfaces to determine the effects of surface functionality and spatial arrangement of the nanodots on the behaviour of the stem cells.

Source:
www.rsc.org

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