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|Raghuraman Kannan (left), and Kattesh Katti, faculty members in the department of radiology at the University of Missouri, have discovered gold nanoparticles that could be used to treat a variety of cancers. Credit: University of Missouri|
University of Missouri School of Medicine scientists explain a potentially new early cancer detection and treatment method using nanoparticles created at MU in an article published in the Proceedings of the National Academy of Sciences. The article illustrates how engineered gold nanoparticles tied to a cancer-specific receptor could be targeted to tumor cells to treat prostate, breast or lung cancers in humans.
"When injected into the body, the Gastrin Releasing Peptide (GRP) cancer receptor serves as a signaling device to the gold nanoparticle, which allows for targeted delivery to the tumor site," said Kattesh Katti, PhD, who wrote the article with Raghuraman Kannan, PhD. "Consequently, the radiotherapeutic properties of such nanoparticles also provides valuable imaging and therapeutic tools that can be used for early cancer detection and therapy in various human cancers."
Because GRP receptor mediated imaging and the radiotherapy specifically targets cancer cells, patients could benefit from a more effective treatment with fewer side effects. GRP receptors are abundant in prostate, breast and small lung cancer cells, and the effectiveness of Katti and Kannan's gold nanoparticles has been proved in numerous studies.
"The development of GRP-receptor specific gold nanoparticles and proof of cancer receptor specificity in living subjects, as described by Drs. Katti and Kannan, is a significant and critical step toward the utility of engineered gold nanoparticles in molecular imaging and therapy of various cancers," said Institute of Medicine member Sanjiv Sam Gambhir, MD, PhD, Virginia and D. K. Ludwig Professor, as well as director of the Molecular Imaging Program and Canary Center for Cancer Early Detection at Stanford University.
Katti, Kannan, and others with the MU School of Medicine Department of Radiology have been researching the development of tumor specific gold nanoparticles for more than five years.
"This discovery presents a plethora of realistic opportunities for clinical translation, not only in the development of nanomedicine-based diagnostic technologies for early stage detection but also for therapies for treating tumors in prostate, breast and small cell lung cancer," Kannan said.
Kannan and Katti have developed a library of more than 85 engineered nanoparticles for use in molecular imaging and therapy. With scientists at the MU Research Reactor (MURR), the most powerful university reactor in the world, they have developed cancer specific therapeutic radioactive gold nanoparticles. MURR is one of only a few sites worldwide able to produce cancer targeting gold nanoparticles.
In 2005, Katti received a prostate cancer research grant that distinguished MU as one of only 12 universities to participate in the National Cancer Institute's national nanotechnology platform partnership. The grant supported MU faculty members in radiology, MURR, veterinary medicine, chemistry, physics and other programs to collaborate in establishing MU as a leader in advancing nanomedicine for the early detection and treatment of cancer.
In addition to serving as director of MU's Cancer Nanotechnology Platform, Katti is a Curators' Distinguished Professor in Radiology and Physics and Margaret Proctor Mulligan Distinguished Professor in Medical Research. Kannan is the Michael J. and Sharon R. Bukstein Distinguished Faculty Scholar in Cancer Research.
The article, titled "Bombesin Functionalized Gold Nanoparticles Show In vitro and In vivo Cancer Receptor Specificity,"
is available online at: www.pnas.org/content/early/2010/04/16/1002143107.abstract
The Proceedings of the National Academy of Sciences of the United States of America is one of the world's most-cited multidisciplinary scientific serials. Since its establishment in 1914, it continues to publish cutting-edge research reports, commentaries, reviews, perspectives, colloquium papers, and actions of the academy.
About University of Missouri-Columbia
The University of Missouri was founded in 1839 in Columbia, Mo., as the first public university west of the Mississippi River and the first state university in Thomas Jefferson's Louisiana Purchase territory. MU provides all the benefits of two universities in one — it's a major land-grant institution and Missouri's largest public research university.
Considered one of the nation's top-tier institutions, Mizzou has a reputation of excellence in teaching and research, and is the flagship campus of the four-campus University of Missouri System. It is one of only 34 public universities, and the only public institution in Missouri, to be selected for membership in the Association of American Universities. MU offers more than 286 degree programs — including 40 online degree options — and is designated as comprehensive doctoral with medical/veterinary by the Carnegie Foundation for the Advancement of Teaching.
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