Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Treat Acne with Coconut Oil and Nano-Bombs

Ph.D. student Dissaya “Nu” Pornpattananangkul is developing a smart system of drug delivery.
Ph.D. student Dissaya “Nu” Pornpattananangkul is developing a smart system of drug delivery.

Abstract:
natural product found in both coconut oil and human breast milk - lauric acid -- shines as a possible new acne treatment thanks to a bioengineering graduate student from the UC San Diego Jacobs School of Engineering. The student developed a "smart delivery system" - published in the journal ACS Nano in March- capable of delivering lauric-acid-filled nano-scale bombs directly to skin-dwelling bacteria (Propionibacterium acnes) that cause common acne.

Treat Acne with Coconut Oil and Nano-Bombs

San Diego, CA | Posted on April 16th, 2010

On Thursday April 15, bioengineering graduate student Dissaya "Nu" Pornpattananangkul will present her most recent work on this experimental acne-drug-delivery system at Research Expo, the annual research conference of the UC San Diego Jacobs School of Engineering.

Common acne, also known as "acne vulgaris," afflicts more than 85 percent of teenagers and over 40 million people in the United States; and current treatments have undesirable side effects including redness and burning. Lauric-acid-based treatments could avoid these side effects, the UC San Diego researchers say.

"It's a good feeling to know that I have a chance to develop a drug that could help people with acne," said Pornpattananangkul, who performs this research in the Nanomaterials and Nanomedicine Laboratory of UC San Diego NanoEngineering professor Liangfang Zhang from the Jacobs School of Engineering.

The new smart delivery system includes gold nanoparticles attached to surfaces of lauric-acid-filled nano-bombs. The gold nanoparticles keep the nano-bombs (liposomes) from fusing together. The gold nanoparticles also help the liposomes locate acne-causing bacteria based on the skin microenvironment, including pH.

Once the nano-bombs reach the bacterial membranes, the acidic microenvironment causes the gold nanoparticles to drop off. This frees the liposomes carrying lauric acid payloads to fuse with bacterial membranes and kill the Propionibacterium acnes bacteria.

"Precisely controlled nano-scale delivery of drugs that are applied topically to the skin could significantly improve the treatment of skin bacterial infections. By delivering drugs directly to the bacteria of interest, we hope to boost antimicrobial efficacy and minimize off-target adverse effects," said Zhang. "All building blocks of the nano-bombs are either natural products or have been approved for clinical use, which means these nano-bombs are likely to be tested on humans in the near future."

Zhang noted that nano-scale topical drug delivery systems face a different set of challenges than systems that use nanotechnology to deliver drugs systematically to people.

Pornpattananangkul and UC San Diego chemical engineering undergraduate Darren Yang confirmed, in 2009 in the journal Biomaterials, the antimicrobial activity of nano-scale packets of lauric acid against Propionibacterium acnes.

Pornpattananangkul, who is originally from Thailand, said that it's just a coincidence that her research involves a natural product produced by coconuts - a staple of Thai cuisine.

Related video cse-ece-ucsd.blogspot.com/2010/04/acne-coconut-oil-and-nanobombthe-movie.html

####

About UCSD Jacobs School of Engineering
From a new solar concentrator design to balancing robots, experimental acne drugs, and wireless heart and brain sensors, UC San Diego graduate engineering students are developing next generation technologies and therapies to address the environmental, health and computing needs of society. These students will present their cutting edge projects at the 29th Annual Jacobs School of Engineering Research Expo on April 15. The theme of this year’s Expo is “Renewables and America’s Energy Future.” Register for Research Expo 2010 here.

For more information, please click here

Contacts:
Daniel Kane
Jacobs School of Engineering
Phone: 858-534-3262

Copyright © UCSD Jacobs School of Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New method allows for greater variation in band gap tunability: The method can change a material's electronic band gap by up to 200 percent January 31st, 2015

Evidence mounts for quantum criticality theory: Findings bolster theory that quantum fluctuations drive strange electronic phenomena January 30th, 2015

Everything You Need To Know About Nanopesticides January 30th, 2015

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Videos/Movies

Los Alamos Develops New Technique for Growing High-Efficiency Perovskite Solar Cells: Researchers’ crystal-production insights resolve manufacturing difficulty January 29th, 2015

'Bulletproof' battery: Kevlar membrane for safer, thinner lithium rechargeables January 28th, 2015

Stomach acid-powered micromotors get their first test in a living animal January 27th, 2015

OCSiAl supports NanoART Imagery Contest January 23rd, 2015

Academic/Education

Rice's Naomi Halas to direct Smalley Institute: Optics pioneer will lead Rice's multidisciplinary science institute January 15th, 2015

SUNY Board Appoints Dr. Alain Kaloyeros as Founding President of SUNY Polytechnic Institute January 13th, 2015

CNSE's Smart System Technology & Commercialization Center Successfully Recertifies as ISO 9001:2008 January 12th, 2015

SUNY Poly Now Accepting Applications to the Colleges of Nanoscale Science and Engineering for Fall 2015: Full Scholarships Available to Incoming CNSE Students January 7th, 2015

Nanomedicine

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Made-in-Singapore rapid test kit detects dengue antibodies from saliva: IBN's MedTech innovation simplifies diagnosis of infectious diseases January 29th, 2015

Iranian Researchers Planning to Produce Edible Insulin January 28th, 2015

Nanoparticles that deliver oligonucleotide drugs into cells described in Nucleic Acid Therapeutics January 28th, 2015

Announcements

New method allows for greater variation in band gap tunability: The method can change a material's electronic band gap by up to 200 percent January 31st, 2015

Evidence mounts for quantum criticality theory: Findings bolster theory that quantum fluctuations drive strange electronic phenomena January 30th, 2015

Everything You Need To Know About Nanopesticides January 30th, 2015

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Personal Care

Sunblock poses potential hazard to sea life August 20th, 2014

AQUANOVA receives Technology Leadership Award 2014 FROST & SULLIVAN honors NovaSOL® Technology again August 12th, 2014

Nanotechnology used in sunscreens: a Mexican achievement May 14th, 2014

Production of Nanocapsule from Sea-Buckthorn Extract in Iran May 3rd, 2014

Nanobiotechnology

DNA nanoswitches reveal how life's molecules connect: An accessible new way to study molecular interactions could lower cost and time associated with discovering new drugs January 30th, 2015

Spider electro-combs its sticky nano-filaments January 28th, 2015

Nanoshuttle wear and tear: It's the mileage, not the age January 26th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE