Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Treat Acne with Coconut Oil and Nano-Bombs

Ph.D. student Dissaya “Nu” Pornpattananangkul is developing a smart system of drug delivery.
Ph.D. student Dissaya “Nu” Pornpattananangkul is developing a smart system of drug delivery.

Abstract:
natural product found in both coconut oil and human breast milk - lauric acid -- shines as a possible new acne treatment thanks to a bioengineering graduate student from the UC San Diego Jacobs School of Engineering. The student developed a "smart delivery system" - published in the journal ACS Nano in March- capable of delivering lauric-acid-filled nano-scale bombs directly to skin-dwelling bacteria (Propionibacterium acnes) that cause common acne.

Treat Acne with Coconut Oil and Nano-Bombs

San Diego, CA | Posted on April 16th, 2010

On Thursday April 15, bioengineering graduate student Dissaya "Nu" Pornpattananangkul will present her most recent work on this experimental acne-drug-delivery system at Research Expo, the annual research conference of the UC San Diego Jacobs School of Engineering.

Common acne, also known as "acne vulgaris," afflicts more than 85 percent of teenagers and over 40 million people in the United States; and current treatments have undesirable side effects including redness and burning. Lauric-acid-based treatments could avoid these side effects, the UC San Diego researchers say.

"It's a good feeling to know that I have a chance to develop a drug that could help people with acne," said Pornpattananangkul, who performs this research in the Nanomaterials and Nanomedicine Laboratory of UC San Diego NanoEngineering professor Liangfang Zhang from the Jacobs School of Engineering.

The new smart delivery system includes gold nanoparticles attached to surfaces of lauric-acid-filled nano-bombs. The gold nanoparticles keep the nano-bombs (liposomes) from fusing together. The gold nanoparticles also help the liposomes locate acne-causing bacteria based on the skin microenvironment, including pH.

Once the nano-bombs reach the bacterial membranes, the acidic microenvironment causes the gold nanoparticles to drop off. This frees the liposomes carrying lauric acid payloads to fuse with bacterial membranes and kill the Propionibacterium acnes bacteria.

"Precisely controlled nano-scale delivery of drugs that are applied topically to the skin could significantly improve the treatment of skin bacterial infections. By delivering drugs directly to the bacteria of interest, we hope to boost antimicrobial efficacy and minimize off-target adverse effects," said Zhang. "All building blocks of the nano-bombs are either natural products or have been approved for clinical use, which means these nano-bombs are likely to be tested on humans in the near future."

Zhang noted that nano-scale topical drug delivery systems face a different set of challenges than systems that use nanotechnology to deliver drugs systematically to people.

Pornpattananangkul and UC San Diego chemical engineering undergraduate Darren Yang confirmed, in 2009 in the journal Biomaterials, the antimicrobial activity of nano-scale packets of lauric acid against Propionibacterium acnes.

Pornpattananangkul, who is originally from Thailand, said that it's just a coincidence that her research involves a natural product produced by coconuts - a staple of Thai cuisine.

Related video cse-ece-ucsd.blogspot.com/2010/04/acne-coconut-oil-and-nanobombthe-movie.html

####

About UCSD Jacobs School of Engineering
From a new solar concentrator design to balancing robots, experimental acne drugs, and wireless heart and brain sensors, UC San Diego graduate engineering students are developing next generation technologies and therapies to address the environmental, health and computing needs of society. These students will present their cutting edge projects at the 29th Annual Jacobs School of Engineering Research Expo on April 15. The theme of this year’s Expo is “Renewables and America’s Energy Future.” Register for Research Expo 2010 here.

For more information, please click here

Contacts:
Daniel Kane
Jacobs School of Engineering
Phone: 858-534-3262

Copyright © UCSD Jacobs School of Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Dressing a metal in various colors: DGIST research developed a technology to coat metal with several nanometers of semiconducting materials January 17th, 2017

Nanoparticle exposure can awaken dormant viruses in the lungs January 17th, 2017

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

Videos/Movies

Manchester scientists tie the tightest knot ever achieved January 13th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Researchers design one of the strongest, lightest materials known: Porous, 3-D forms of graphene developed at MIT can be 10 times as strong as steel but much lighter January 7th, 2017

The researchers created a tiny laser using nanoparticles January 5th, 2017

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Arrowhead Provides Response to New Minority Shareholder Announcement January 7th, 2017

Announcements

Dressing a metal in various colors: DGIST research developed a technology to coat metal with several nanometers of semiconducting materials January 17th, 2017

Nanoparticle exposure can awaken dormant viruses in the lungs January 17th, 2017

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

Personal Care/Cosmetics

Programmable materials find strength in molecular repetition May 23rd, 2016

Common nanoparticle has subtle effects on oxidative stress genes May 11th, 2016

NRL reveals novel uniform coating process of p-ALD April 21st, 2016

New ORNL method could unleash solar power potential March 16th, 2016

Nanobiotechnology

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project