Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers

Abstract:
Nanoparticle-core polymer holds promise as an absorbable, weight-bearing replacement for traditional graft materials

Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers

Worcester, MA | Posted on April 6th, 2010

Orthopedic surgeons are often hamstrung by less-than-ideal grafting material when performing surgeries for complex bone injuries resulting from trauma, aging or cancer. Conventional synthetic bone grafts are typically made of stiff polymers or brittle ceramics, and cannot readily conform to the complex and irregular shapes that often result from injury; in addition, they often require metallic fixation devices that require open surgeries to insert and remove. Ideally, a scaffolding graft would conform to complex shapes of an injury site, provide weight-bearing support, require less invasive surgical delivery, and ultimately disappear when no longer needed.

Using a nanoparticle core, Jie Song, PhD, assistant professor of orthopedics & physical rehabilitation and cell biology at the University of Massachusetts Medical School, and postdoctoral fellow Jianwen Xu, have fashioned a new type of tissue and bone scaffolding polymer that addresses a number of these long-standing limitations. Research published in the online Early Edition of Proceedings of the National Academy of Sciences, describes the development of a class of heat-activated smart materials that combine tissue-like properties and strength that are clinically safe to deploy and able to integrate with surrounding tissue.

The key feature of the new polymer is its heat-activated malleability and shape memory. Using CT scans and MRI images of the injury site, Song envisions physicians creating a polymer mold of the scaffolding needed to stabilize a skeletal injury site, in the lab, prior to surgery. Heat activated at a safe 50°C, the smart polymer could then be reshaped to a more compressed form suitable for insertion in the body through a small, minimally invasive incision. Once at the injury site, the idea is to then thermally re-activate the polymer to cause it to revert to its original, pre-molded shape in seconds, according to Song.

In addition to providing mechanical stabilization to the skeletal structure, because the biodegradable material is similar to those used in dissolvable sutures, it can be safely reabsorbed by the body as it breaks down over time. Therefore, there is no need for a second surgery to remove the implant. Additionally, as the scaffolding degrades, the polymer provides a porous structure that promotes tissue growth and integration. At the same time, the polymer has the ability to deliver therapeutics to accelerate new bone growth and integration.

"Strong and resorbable smart implants could have paradigm-changing impact on a number of surgical interventions that currently rely on the use of more invasive and less effective metallic cages, fixators and stents," said Song. "From spinal fusion to alleviate chronic lower back pain, vertebroplasty for treating vertebral fractures to angioplasty for widening narrowed or obstructed blood vessels, there are tremendous clinical applications for smart polymers."

Song and colleagues are testing the safety and efficacy of the material in animal models, which they hope will pave the way for future clinical trials.

####

About University of Massachusetts Medical School
The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $240 million in research funding annually, 80 percent of which comes from federal funding sources. The mission of the Medical School is to advance the health and well-being of the people of the commonwealth and the world through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care.

For more information, please click here

Contacts:
Jim Fessenden

508-856-2000

Copyright © Eurekalert

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

Possible Futures

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

Academic/Education

The Institute of Applied Physics at the University of Tsukuba near Tokyo in Japan uses Deben's ARM2 detector to better understand catalytic reaction mechanisms June 27th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

SUNY Poly Professor Eric Lifshin Selected for ‘Fellow of the Microanalysis Society’ Position for Significant Contributions to Microanalysis June 13th, 2018

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Nanomedicine

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Announcements

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Tuning into quantum: Scientists unlock signal frequency control of precision atom qubits July 16th, 2018

Nanobiotechnology

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Arrowhead Presents New Clinical Data on ARO-AAT at Alpha-1 National Education Conference July 1st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project