Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers

Abstract:
Nanoparticle-core polymer holds promise as an absorbable, weight-bearing replacement for traditional graft materials

Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers

Worcester, MA | Posted on April 6th, 2010

Orthopedic surgeons are often hamstrung by less-than-ideal grafting material when performing surgeries for complex bone injuries resulting from trauma, aging or cancer. Conventional synthetic bone grafts are typically made of stiff polymers or brittle ceramics, and cannot readily conform to the complex and irregular shapes that often result from injury; in addition, they often require metallic fixation devices that require open surgeries to insert and remove. Ideally, a scaffolding graft would conform to complex shapes of an injury site, provide weight-bearing support, require less invasive surgical delivery, and ultimately disappear when no longer needed.

Using a nanoparticle core, Jie Song, PhD, assistant professor of orthopedics & physical rehabilitation and cell biology at the University of Massachusetts Medical School, and postdoctoral fellow Jianwen Xu, have fashioned a new type of tissue and bone scaffolding polymer that addresses a number of these long-standing limitations. Research published in the online Early Edition of Proceedings of the National Academy of Sciences, describes the development of a class of heat-activated smart materials that combine tissue-like properties and strength that are clinically safe to deploy and able to integrate with surrounding tissue.

The key feature of the new polymer is its heat-activated malleability and shape memory. Using CT scans and MRI images of the injury site, Song envisions physicians creating a polymer mold of the scaffolding needed to stabilize a skeletal injury site, in the lab, prior to surgery. Heat activated at a safe 50°C, the smart polymer could then be reshaped to a more compressed form suitable for insertion in the body through a small, minimally invasive incision. Once at the injury site, the idea is to then thermally re-activate the polymer to cause it to revert to its original, pre-molded shape in seconds, according to Song.

In addition to providing mechanical stabilization to the skeletal structure, because the biodegradable material is similar to those used in dissolvable sutures, it can be safely reabsorbed by the body as it breaks down over time. Therefore, there is no need for a second surgery to remove the implant. Additionally, as the scaffolding degrades, the polymer provides a porous structure that promotes tissue growth and integration. At the same time, the polymer has the ability to deliver therapeutics to accelerate new bone growth and integration.

"Strong and resorbable smart implants could have paradigm-changing impact on a number of surgical interventions that currently rely on the use of more invasive and less effective metallic cages, fixators and stents," said Song. "From spinal fusion to alleviate chronic lower back pain, vertebroplasty for treating vertebral fractures to angioplasty for widening narrowed or obstructed blood vessels, there are tremendous clinical applications for smart polymers."

Song and colleagues are testing the safety and efficacy of the material in animal models, which they hope will pave the way for future clinical trials.

####

About University of Massachusetts Medical School
The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $240 million in research funding annually, 80 percent of which comes from federal funding sources. The mission of the Medical School is to advance the health and well-being of the people of the commonwealth and the world through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care.

For more information, please click here

Contacts:
Jim Fessenden

508-856-2000

Copyright © Eurekalert

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New Biological Nano-Fertilizers Presented in Iran as Appropriate Replacements for Chemical Fertilizers April 18th, 2015

Iranian Foodstuff, Agricultural Industries Welcome Nanotechnology Packaging Bags April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Possible Futures

A glass fiber that brings light to a standstill: By coupling photons to atoms, light in a glass fiber can be slowed down to the speed of an express train; for a short while it can even be brought to a complete stop April 9th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanocomposites Market Growth, Industry Outlook To 2020 by Grand View Research, Inc. March 21st, 2015

Academic/Education

JPK reports on the use of the NanoWizardŽ 3 AFM system at the Hebrew University of Jerusalem April 14th, 2015

UK National Graphene Institute Selects Bruker as Official Partner: World-Leading Graphene Research Facility Purchases Multiple Bruker AFMs April 7th, 2015

SUNY Poly CNSE and Title Sponsor SEFCU Name Capital Region Teams Advancing to the Final Round of the 2015 New York Business Plan Competition March 30th, 2015

LAMDAMAP 2015 hosted by the University March 26th, 2015

Nanomedicine

Optical resonance-based biosensors designed for medical applications April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Novel nanoparticles could save soldiers' lives after explosions April 15th, 2015

Nanoparticles at specific temperature stimulate antitumor response: Dartmouth researchers identify precise heat to boost immune system against cancer tumors April 14th, 2015

Announcements

New Biological Nano-Fertilizers Presented in Iran as Appropriate Replacements for Chemical Fertilizers April 18th, 2015

Iranian Foodstuff, Agricultural Industries Welcome Nanotechnology Packaging Bags April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Nanobiotechnology

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Study shows novel pattern of electrical charge movement through DNA April 14th, 2015

UAB researchers develop a harmless artificial virus for gene therapy April 8th, 2015

Pavel Levkin Is Granted Heinz Maier-Leibnitz Prize April 8th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE