Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Cancer Therapy Using Unique Imaging, Delivery System Focus of NSF CAREER Award

Marissa Nichole Rylander, Virginia Tech assistant professor jointly appointed in the Department of Mechanical Engineering and Virginia Tech – Wake Forest University School of Biomedical Engineering and Sciences (SBES), works in her laboratory.
Marissa Nichole Rylander, Virginia Tech assistant professor jointly appointed in the Department of Mechanical Engineering and Virginia Tech – Wake Forest University School of Biomedical Engineering and Sciences (SBES), works in her laboratory.

Abstract:
Preliminary research on cancer treatments using nanotechnology and laser therapy has led to a National Science Foundation (NSF) Faculty Early Career Development (CAREER) award for Marissa Nichole Rylander, Virginia Tech assistant professor jointly appointed in the Department of Mechanical Engineering and Virginia Tech - Wake Forest University School of Biomedical Engineering and Sciences (SBES).

Cancer Therapy Using Unique Imaging, Delivery System Focus of NSF CAREER Award

Blacksburg, VA | Posted on March 29th, 2010

The CAREER grant will allow Rylander to develop and utilize a novel sensing system she co-invented called the "holey scaffold." Her design will characterize the three-dimensional and time dependent motion of a nanoparticle used in a treatment process. It will also illustrate the dynamic, light-activated thermal and chemical response of the tumor to the nanoparticle-mediated laser therapy for varying nanoparticle properties and laser parameters within both in vitro and in vivo tumor systems.

The "holey scaffold" is the first system capable of minimally invasive and non-destructive light sensitive, molecular sensing and control of biological and transport processes within living organisms. Rylander said the "holey scaffold can be visualized as a miniature microscope used in conjunction with a living system. The holey scaffold is built from tissue scaffolding and is embedded with a network of hollow microchannels. Typically made from biodegradable synthetics or biological materials such as collagen, the scaffold promotes tissue growth.

Some microchannels can be used to perform controlled delivery of biological agents (e.g. nutrients, growth factors, tumor cells, nanoparticles, therapeutic agents). Other microchannels can be used to introduce micron size fibers for non-destructive, in situ, and real-time imaging of biological processes or therapeutic light delivery.

Rylander, who joined the Virginia Tech faculty in 2006, earned her doctorate in biomedical engineering from the University of Texas at Austin (UT) in 2005 where she remained as a post doctoral fellow jointly appointed in the biomedical engineering department and Institute for Computational Engineering and Sciences.

Her CAREER award, in part, is a continuation of work at UT on characterization of injury and heat shock protein (HSP) expression in prostate cancer cells and tumors in response to elevated temperatures associated with water bath and laser heating. Knowledge of the HSP expression distribution in tumors allows the identification of tumor regions with a high likelihood of survival and recurrence. Therefore, therapeutic procedures can be modified to optimize HSP expression to enhance treatment outcome.

Based on these experimental measurements she developed novel computational treatment planning models to predict the temperature, HSP expression, and injury at the cellular and tissue level in response to laser therapy. Rylander's goal with her $400,000 CAREER award is to ultimately develop more effective and selective laser cancer therapies by incorporating novel nanoparticles to enhance laser based thermal and chemical treatments.

With her holey scaffold design, she will be able to measure dynamic nanoparticle mass transport, temperature, cell viability, HSP expression, and reactive oxygen species (ROS) production in real-time within an in vitro tumor in a bioreactor or an in vivo tumor within a mouse. She will use a variety of nanoparticles including carbon nanotubes, novel embodiments of carbon nanotubes and fullerenes, and carbon nanohorns in combination with laser irradiation.

By analyzing the tumor's response to varying nanoparticle types, delivery methods, and laser parameters, Rylander expects to be able to create a multi-component, treatment planning computational model for nanoparticle-medicated laser therapy that can be used by clinicians to determine appropriate nanoparticle properties and laser parameters to achieve selective and effective cancer treatment.

Her CAREER award will also allow her to create a course on nanotherapeutics for undergraduates and graduate students. It will explore the basics of nanoparticles, the experimental measurement of nanoparticle interactions with biological tissues, photothermal, and photochemical mechanisms of nanotherapy. The course will also address the computer modeling of cellular and tissue responses to nanoparticles.

This CAREER project will also establish a multi-tier education and outreach plan that will integrate research elements and discoveries into multidisciplinary educational and research experiences for high school students and teachers from underprivileged schools in West Virginia and undergraduates and graduate students at Virginia Tech.

"It is my long-term career goal to be able to develop effective and selective cancer therapies based on nanotechnology that can be readily implemented as a viable treatment option for millions of cancer patients," Rylander said.

####

About Virginia Tech
Through a combination of its three missions of learning, discovery, and engagement, Virginia Tech continually strives to accomplish the charge of its motto: Ut Prosim (That I May Serve).

For more information, please click here

Contacts:
Phone news office: 540-231-8508
Phone main: 540-231-6000
Fax news office: 540-231-4040

Copyright © Virginia Tech

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Dolomite to launch Meros TCU-100 temperature controller at Lab-on-a-Chip & Microarray World Congress September 15th, 2014

Fonon at Cutting-Edge of 3D Military Printing: Live-Combat Scenarios Could See a Decisive Advantage with 3D Printing September 15th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Possible Futures

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Academic/Education

Malvern technology delivers Malvern reliability in multi-disciplinary lab at Queen Mary University London September 9th, 2014

State University of New York Trustees Unanimously Approve SUNY Polytechnic Institute (SUNY Poly) as New Name for Merged SUNY CNSE / SUNYIT September 9th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

RMIT delivers $30m boost to micro and nano-tech August 26th, 2014

Nanotubes/Buckyballs

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Berkeley Lab Licenses Boron Nitride Nanotube Technology: New material has unique mechanical and electronic properties September 13th, 2014

Global Energy Systems Signs Master Sales Agreement with China Aviation Supplies Group September 4th, 2014

Breakthrough for Carbon Nanotube Solar Cells: Polychiral carbon nanotube mixture absorbs more sunlight September 3rd, 2014

Nanomedicine

Treatment of Cell Infection by Nanotechnology September 15th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

Iranian Scientists Discover Nanotechnology Method to Remove Limitations in Tumor Surgery September 11th, 2014

Iranian Nanotechnology Scientists Produce Polymeric Scaffolds for Tissue Engineering September 11th, 2014

Announcements

Dolomite to launch Meros TCU-100 temperature controller at Lab-on-a-Chip & Microarray World Congress September 15th, 2014

Fonon at Cutting-Edge of 3D Military Printing: Live-Combat Scenarios Could See a Decisive Advantage with 3D Printing September 15th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

Simple, Cost-Effective Method Proposed for Synthesizing Zinc Oxide Nanopigments September 15th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Elusive Quantum Transformations Found Near Absolute Zero: Brookhaven Lab and Stony Brook University researchers measured the quantum fluctuations behind a novel magnetic material's ultra-cold ferromagnetic phase transition September 15th, 2014

Rice rolls 'neat' nanotube fibers: Rice University researchers' acid-free approach leads to strong conductive carbon threads September 15th, 2014

First Colloid and Polymer Science Lecture awarded to Orlin D. Velev: Chemical engineer honored for outstanding research in colloid science September 12th, 2014

Advanced Light Source Sets Microscopy Record| Berkeley Lab Researchers Achieve Highest Resolution Ever with X-ray Microscopy September 11th, 2014

Nanobiotechnology

NanoStruck has a High Recovery Rate on Mine Tailings: retrieval of up to 96% of Gold, 88% of Silver and 86% of Palladium September 12th, 2014

Boosting armor for nuclear-waste eating microbes September 12th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE