Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticles Cooperate to Detect and Treat Tumors

Abstract:
If one nanoparticle is good, two may be better, especially when they are designed to cooperate with each other to diagnose and treat cancer. That finding comes from work led by Michael Sailor, Ph.D., a member of the Center of Nanotechnology for Treatment, Understanding, and Monitoring of Cancer at the University of California, San Diego, and published in the journal Advanced Materials.

Nanoparticles Cooperate to Detect and Treat Tumors

Bethesda, MD | Posted on March 22nd, 2010

Dr. Sailor and his colleagues, including fellow Center member Erkki Ruoslahti, M.D., Ph.D., of the Burnham Institute for Medical Research at the University of California, Santa Barbara, and Sangeeta Bhatia of the Howard Hughes Medical Institute and a member of the MIT-Harvard Center for Cancer Nanotechnology Excellence, have had success developing multifunctional nanoparticles that incorporate several functions - imaging and drug delivery, for example - in one nanoparticle. However, the investigators felt that fitting multiple functions into one nanoparticle was sometimes problematic in terms of getting the right combination of properties needed to fulfill two or more missions inside the body.

For this study, Dr. Sailor and his collaborators decided to create two nanoparticles. One, a polymer-coated gold nanorod, was designed to accumulate in tumors and become warm when irradiated with near infrared light. The second nanoparticle, made of a thermally responsive lipid mixture, was designed to release a drug payload only when encountering cells warmed to 45° C, that is, only where the first nanoparticle had heated tumors.

After injecting the two nanoparticles together into tumor-bearing mice, the investigators illuminated tumors with near infrared light. They then observed that the drug-containing nanoparticles began accumulating and releasing their drug around the tumors. More importantly, the researchers found that the drug killed more cells when the two nanoparticles were used in combination than it did when administered alone or when just the drug-loaded nanoparticle was used. Dr. Sailor's team also observed that subsequent tumor growth was significantly impaired, while the treated mice displayed few adverse side effects from the therapy.

This work, which is detailed in a paper titled, "Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery," was supported by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's Web site.

View abstract: www3.interscience.wiley.com/journal/123191104/abstract?CRETRY=1&SRETRY=0

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Imec Reports Four Percent Growth for 2013 Fiscal Year End —Continues to Accelerate Innovation Through Global Collaborations and Technological Breakthroughs in Nanoelectronics— April 24th, 2014

Multicapacity Microreactor for Catalyst Characterisation April 24th, 2014

Making graphene work for real-world devices: Fundamental research in phonon scattering helps researchers design graphene materials for applications April 24th, 2014

Return on investment for kit and promotion materials April 24th, 2014

Possible Futures

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

The "Tipping Point" February 12th, 2014

Academic/Education

Global leader in solar cell manufacturing eyes New York for major expansion outside of Japan: CNSE and Solar Frontier Explore $700 Million Investment, Job Creation in New York State April 22nd, 2014

University of Waterloo Visits China to Strengthen Bonds With Research Partners April 21st, 2014

Director Wally Pfister joins UC Berkeley neuroengineers to discuss the science behind ‘Transcendence’ April 7th, 2014

First annual science week highlights STEM pipeline and partnerships: UB, SUNY Buffalo State and ECC team up with the City of Buffalo and its schools for April 7-11 events April 3rd, 2014

Nanomedicine

Return on investment for kit and promotion materials April 24th, 2014

University of Tehran Researchers Invent Non-Enzyme Sensor to Detect Blood Sugar April 23rd, 2014

Gold nanoparticles help target, quantify breast cancer gene segments in a living cell April 23rd, 2014

QuantuMDx announce prototype handheld lab for 15 minute malaria diagnosis and drug resistance testing April 23rd, 2014

Announcements

Imec Reports Four Percent Growth for 2013 Fiscal Year End —Continues to Accelerate Innovation Through Global Collaborations and Technological Breakthroughs in Nanoelectronics— April 24th, 2014

Multicapacity Microreactor for Catalyst Characterisation April 24th, 2014

Making graphene work for real-world devices: Fundamental research in phonon scattering helps researchers design graphene materials for applications April 24th, 2014

Return on investment for kit and promotion materials April 24th, 2014

Nanobiotechnology

University of Tehran Researchers Invent Non-Enzyme Sensor to Detect Blood Sugar April 23rd, 2014

Gold nanoparticles help target, quantify breast cancer gene segments in a living cell April 23rd, 2014

Guo Lab Shows Potential of RNA as Heat-resistant Polymer Material for Nanoarchitectures April 23rd, 2014

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE