Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Research team uses nanotechnology to deliver targeted cancer treatment

On Target: Lavasanifar (left) and fellow researcher Samar Hamdy are developing complex nanoparticles that range from 100 to 500 nanometres in size.  Photo by Pete Yee
On Target: Lavasanifar (left) and fellow researcher Samar Hamdy are developing complex nanoparticles that range from 100 to 500 nanometres in size. Photo by Pete Yee

Abstract:
A team of researchers at the University of Alberta are using tiny technology for a big purpose — the improvement of cancer treatment.

By Jonathan Taves, Deputy News Editor

Research team uses nanotechnology to deliver targeted cancer treatment

Alberta | Posted on March 9th, 2010

The group, led by Afsaneh Lavasanifar, an associate professor in the Faculty of Pharmacy, is working on a nanoparticle that boost the human body's immune system in its fight against tumours.

"Usually, the immune system of the body should recognize them and basically destroy the cancer cells. But in some cases, because of separate mutations that happen in cancer cells, they make themselves resistant to the effect of the immune cells," Lavasanifar explained.

The developers have created a nanoparticle that is bound with antigens, which are biological molecules that are taken in by cells that help immunity.

"We also load other materials that are called adjuvants and they are supposed to boost the immune response. Then together they are being captured, because their size is optimum for uptake by immune cells," Lavasanifar said. "One of the most important of these cells are dendritic cells. Dendritic cells can engulf antigens, and then they basically order other cells of the immune system what to do."

Lavasanifar added that this treatment can also boost the effectiveness of chemotherapy.

"Another goal we have in my research group is to target chemotherapy drugs towards the cancer cells. The long-term objective of our research group is to combine the two, chemo and immunotherapy, to get better response from both of them. We believe that combing the two approaches will lead to the eradication of the cancer [cells] and the removal of the tumour," she said.

This targeted approach can have many benefits.

"These materials are supposed to lower the dose of chemotherapy that is received by the patients. Overall, they may be cost effective because you need a smaller dose of the drug. And then you don't need to deal with the side effects of the drugs," Lavasanifar said, citing the toll standard chemotherapy procedures can have on the body.

She explained how changing the types of antigens can allow different types of cancer to be treated. One of the group's research focuses hits especially close to home, as the professor of pharmacy who started work on this project, John Samuel, succumbed to cancer at the age of 53 in 2007.

"We are trying to target the cancers that are hard to treat right now. One of those types of cancers is pancreatic cancer, for example. Another one is head and neck cancer — unfortunately, that is the type of cancer that Dr. Samuel actually passed away from," Lavasanifar noted. "He asked me to take over his staff and research program."

Aiming at different types of cells requires modification of the size and surface properties of the nanoparticles.

"If we want to target a tumour, than we have to look at a different size. We have to go below 100 nanometres," Lavasanifar explained. "By doing that, we make these nanoparticles not be recognized by the immune cells so they are not being taken up very rapidly. Then they have a chance to accumulate in the tumour."

However, Lavasanifar noted that clinical trials of the technology haven't been as promising as hoped, and obstacles remain ahead.

"People think that one of the challenges is the immune tolerance that the body develops during cancer's progression. So one of the challenges is to break the tolerance of the body against this cancer vaccine. That is one area we're doing research on," she said.

Another obstacle is the cost of such intricate treatment, but Lavasanifar is optimistic that will decrease.

"As we move along, maybe we'll find better ways to optimize these products," she said. "It's quite costly compared to what is already there, but if they are more effective for a disease like cancer, that's what we have to do."

####

About University of Alberta
The University of Alberta’s vision since its inception more than 100 years ago has been to be one of the world’s great universities for the public good. In the words of our first president, Henry Marshall Tory, the U of A is an institution directed toward the “uplifting of the whole people” in Alberta, across Canada, and around the world. This vision endures in the university’s current vision document, Dare to Discover, and our academic plan, Dare to Deliver.

For more information, please click here

Copyright © University of Alberta

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Maximum Precision in 3D Printing: New complete solution makes additive manufacturing standard for microfabrication February 26th, 2015

Possible Futures

European roadmap for graphene science and technology published February 25th, 2015

Quantum research past, present and future for discussion at AAAS February 16th, 2015

World’s first compact rotary 3D printer-cum-scanner unveiled at AAAS by NTU Singapore start-up: With production funded by crowdsourcing, the first unit will be delivered to the United States in March February 16th, 2015

Nanotechnology Electric Vehicle (EV) Market Analysis Report 2015: According to Radiant Insights, Inc February 13th, 2015

Academic/Education

NanoTecNexus Launches New App for Learning About Nanotechnology—STEM Education Project Spearheaded by Interns February 26th, 2015

SUNY Poly CNSE Researchers and Corporate Partners to Present Forty Papers at Globally Recognized Lithography Conference: SUNY Poly CNSE Research Group Awarded Both ‘Best Research Paper’ and ‘Best Research Poster’ at SPIE Advanced Lithography 2015 forum February 25th, 2015

KIT Increases Commitment in Asia: DAAD Funds Two New Projects: Strategic Partnerships with Chinese Universities and Communi-cation Technologies Network February 22nd, 2015

Minus K Technology Announces Its 2015 Vibration Isolator Educational Giveaway to U.S. Colleges and Universities February 18th, 2015

Nanomedicine

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

Cutting-edge technology optimizes cancer therapy with nanomedicine drug combinations: UCLA bioengineers develop platform that offers personalized approach to treatment February 24th, 2015

Optical nanoantennas set the stage for a NEMS lab-on-a-chip revolution February 24th, 2015

Announcements

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

Nanobiotechnology

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Bacteria network for food: Bacteria connect to each other and exchange nutrients February 23rd, 2015

Building tailor-made DNA nanotubes step by step: New, block-by-block assembly method could pave way for applications in opto-electronics, drug delivery February 23rd, 2015

Better batteries inspired by lowly snail shells: Biological molecules can latch onto nanoscale components and lock them into position to make high performing Li-ion battery electrodes, according to new research presented at the 59th annual meeting of the Biophysical Society February 12th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE