Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nano-motors facilitate communication between brain cells

Dr Kittler's research is published in the 14 January issue of Neuron journal
Dr Kittler's research is published in the 14 January issue of Neuron journal

Abstract:
MRC-funded scientists led by Dr Josef Kittler (UCL Neuroscience) have identified how nano-sized motors in nerve cells help to regulate the balance of communication in the brain.

Nano-motors facilitate communication between brain cells

UK | Posted on January 22nd, 2010

The findings may also help to explain why communication between nerve cells is disrupted in Huntington's disease, leading to altered electrical behaviour of nerve cells in this disease.

Nerve cells send signals to each other by releasing chemicals at specialized junctions between the cells called synapses. One key neurotransmitter, called GABA, acts on special proteins (GABA receptors) to generate inhibition, which stops the brain from becoming too excitable. In a paper published this week in the journal Neuron, Dr Kittler reveals how a protein named HAP1, working together with molecular motor proteins, helps to guide the GABA receptors to the synapses.

Alison Twelvetrees (UCL Neuroscience) first author on the study, said: "This work advances our understanding of how the GABA receptor proteins are delivered to synapses to control the level of inhibition in the brain. We show that the receptors are transported to synapses by small nanometer-sized motors, on intracellular protein tracks called microtubules".

In the inherited neurological disorder Huntington's disease, a mutation in the gene for the protein huntingtin leads to the production of a mutant huntingtin protein. This can disrupt several aspects of normal nerve cell function, including the function of the synapses. This altered function of synapses is likely to be an important contributor to the progression of the disorder.

Lead author Dr Josef Kittler said: "Our work shows how the transport of the GABA receptors to synapses is disrupted by the protein that is mutated in Huntington's disease, and adds another piece to the complex puzzle of how synaptic communication in the brain gets disrupted in this disorder".

The research is a good example of how understanding the way that tiny, but crucial, cell components such as synapses function contributes to understanding problems that affect whole body systems.

For more information about Dr Kittler's research, please visit his webpage:

www.ucl.ac.uk/npp/jk.html

####

About University College London
UCL was founded in 1826 as a radically different university, opening up English higher education for the first time to people of all beliefs and social backgrounds. That radical tradition remains alive today. Our research strategy commits us to addressing UCL's 'Grand Challenges', by working together right across the university in order to tackle the problems that face us today - in global health, sustainable cities, intercultural understanding, and human wellbeing. We believe in undertaking fundamental research and in applying it.

For more information, please click here

Copyright © University College London

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Govt.-Legislation/Regulation/Funding/Policy

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Possible Futures

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanocomposites Market Growth, Industry Outlook To 2020 by Grand View Research, Inc. March 21st, 2015

Nanotechnology Drug Delivery Market in the US 2012-2016 : Latest Report Available by Radiant Insights, Inc March 16th, 2015

Molecular Machines

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

New remote control for molecular motors: It is now theoretically possible to remotely control the direction in which magnetic molecules spin, which opens the door to designing applications based on molecular motors March 16th, 2015

Monitoring the real-time deformation of carbon nanocoils under axial loading February 18th, 2015

Nanomedicine

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Graphene reduces wear of alumina ceramic March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Announcements

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Nanobiotechnology

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Dolomite’s microfluidics technology ideal for B cell encapsulation March 24th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

TGAC's take on the first portable DNA sequencing 'laboratory': First remote laboratory allows researchers to conduct real-time anaylsis March 19th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE