Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > IMEC’s unique micronail chip makes electronics and bio cells communicate

Cortical neurons engulf microscopic nail structures on the surface of IMEC’s micronail chip (3-day in vitro culture)
Cortical neurons engulf microscopic nail structures on the surface of IMEC’s micronail chip (3-day in vitro culture)

Abstract:
IMEC presents a unique microchip with microscopic nail structures that enable close communication between the electronics and biological cells. The new chip is a mass-producible, easy-to-use tool in electrophysiology research, for example for fundamental research on the functioning and dysfunctioning of the brain. Each micronail structure serves as a close contact-point for one cell, and contains an electrode that can very accurately record and trigger in real-time the electrical activity of an individual electrogenic cell in a network.

IMEC’s unique micronail chip makes electronics and bio cells communicate

Leuven, Belgium | Posted on November 12th, 2009

Electrogenic cells such as cardiomyocytes (heart cells) or neurons (brain cells) rely on electrical signals to communicate with one another. Knowledge of the electrical activity of these cells is essential to gain insights in the communication process of these cells, to unravel the cause of brain disorders such as Alzheimer's or Parkinson's disease, or validate the effect of drugs on cardiac cells in the struggle against cardiac diseases, etc. IMEC's new micronail chip is the ideal instrument to study the communication mechanisms between cells. The electrodes in IMEC's micronail chip are downsized to the size of cells and even smaller. They consist of tiny nail structures made of a metal stem covered with an oxide layer, and a conductive (e.g. gold or titaniumnitride) tip. When cells are applied on the chip surface, their cell membrane strongly engulfs the nail structures, thereby realizing an intimate contact with the electrode. This very close contact improves the signal-to-interference ratio enabling precise recording of electrical signals and electrical stimulation of single cells.

"We tackled several challenges to realize this micronail chip such as keeping the cells alive on the chip surface; combining the wet cell solution with the electronics underneath without destroying the electronics; guiding the cell growth so that the cell body is just on top of one individual electrode; and last but not least: bring the cells as close as possible to the chip surface. Know, we have a unique instrument to record and interpret the signals of the neurons. We can also stimulate neurons and follow up the consequences to unravel the functioning of our brain," said Wolfgang Eberle, Group manager Bioelectronic systems.

Kris Verstreken, Director Bio-Nanoelectronics added, "Little is known about the functioning of our brain. Where do emotions origin? How do we build up memories? Or what is the cause of brain diseases such as Parkinson's disease or Alzheimer's disease? Many processes in our brain are unknown. Neurons are very plastic cells, continuously forming new connections and breaking up or rebuilding new ones. But how do they do that? And which are the consequences for learning and development? On the long term, we can use the knowledge that we build up with in vitro experiments on our micronail chip to diagnose diseases, or even develop therapies, by stimulating cells, or building new communication bridges between cells after a brain infarct."

IMEC is a registered trademark for the activities of IMEC International (a legal entity set up under Belgian law as a "stichting van openbaar nut"), IMEC in Belgium (IMEC vzw supported by the Flemish Government), stichting IMEC Nederland (IMEC-NL) and IMEC Taiwan Co. (IMEC-TW).

####

About IMEC
IMEC performs world-leading research in nanotechnology. IMEC leverages its scientific knowledge with the innovative power of its industrial partnerships in ICT, healthcare and energy. IMEC delivers industry-relevant technology solutions. In a unique high-tech environment, its international top talent is committed to providing the building blocks for a better life in a sustainable society.
IMEC is headquartered in Leuven, Belgium, and has offices in Belgium, the Netherlands, Taiwan, US, China and Japan. Its staff of more than 1,650 people include over 550 industrial residents and guest researchers. In 2008, IMEC's revenue (P&L) was 270 million euro.

For more information, please click here

Contacts:
Katrien Marent
Director of External Communications
Mobile: +32 474 30 28 66,

Barbara Kalkis
Maestro Marketing & PR
T: +1 408 996 9975

Copyright © IMEC

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

SEMATECH to Showcase Innovation and Advances in Manufacturing at SEMICON Japan 2014: SEMATECH experts will share the latest techniques, emerging trends and best practices in advanced manufacturing strategies and methodologies November 26th, 2014

Australian startup creates world’s first 100% cotton hydrophobic T-Shirts November 26th, 2014

The mysterious 'action at a distance' between liquid containers November 26th, 2014

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

Possible Futures

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Researchers discern the shapes of high-order Brownian motions November 17th, 2014

VDMA Electronics Production Equipment: Growth track for 2014 and 2015 confirmed: Business climate survey shows robust industry sector November 14th, 2014

Open Materials Development Will Be Key for HP's Success in 3D Printing: HP can make a big splash in 3D printing, but it needs to shore up technology claims and avoid the temptation of the razor/razor blade business model in order to flourish November 11th, 2014

Nanomedicine

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Nanoelectronics

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

Leti Will Present 17 Papers at 2014 IEDM; the Highest-ever Total Includes Four Invited Papers: Institute also Will Present its Latest Results in Key Technologies and Its Roadmap for Silicon Nano-technologies at Workshop November 13th, 2014

Breakthrough in molecular electronics paves the way for DNA-based computer circuits in the future: DNA-based programmable circuits could be more sophisticated, cheaper and simpler to make October 27th, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Announcements

SEMATECH to Showcase Innovation and Advances in Manufacturing at SEMICON Japan 2014: SEMATECH experts will share the latest techniques, emerging trends and best practices in advanced manufacturing strategies and methodologies November 26th, 2014

Australian startup creates world’s first 100% cotton hydrophobic T-Shirts November 26th, 2014

The mysterious 'action at a distance' between liquid containers November 26th, 2014

'Giant' charge density disturbances discovered in nanomaterials: Juelich researchers amplify Friedel oscillations in thin metallic films November 26th, 2014

Tools

Renishaw receives Queen's Award for spectroscopy developments November 25th, 2014

JPK reports on the use of AFM and the CellHesion module to study plant cells at the University of Queensland November 25th, 2014

A*STAR SIMTech wins international award for breaking new ground in actuators: SIMTech invention can be used in an array of industries, and is critical for next generation ultra-precision systems November 24th, 2014

Professional AFM Images with a Three Step Click SmartScan by Park Systems Revolutionizes Atomic Force Microscopy by Automatizing the Imaging Process November 24th, 2014

Nanobiotechnology

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Implementation of DNA Chains in Designing Nanospin Pieces November 9th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE