Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > IMECís unique micronail chip makes electronics and bio cells communicate

Cortical neurons engulf microscopic nail structures on the surface of IMECís micronail chip (3-day in vitro culture)
Cortical neurons engulf microscopic nail structures on the surface of IMECís micronail chip (3-day in vitro culture)

Abstract:
IMEC presents a unique microchip with microscopic nail structures that enable close communication between the electronics and biological cells. The new chip is a mass-producible, easy-to-use tool in electrophysiology research, for example for fundamental research on the functioning and dysfunctioning of the brain. Each micronail structure serves as a close contact-point for one cell, and contains an electrode that can very accurately record and trigger in real-time the electrical activity of an individual electrogenic cell in a network.

IMECís unique micronail chip makes electronics and bio cells communicate

Leuven, Belgium | Posted on November 12th, 2009

Electrogenic cells such as cardiomyocytes (heart cells) or neurons (brain cells) rely on electrical signals to communicate with one another. Knowledge of the electrical activity of these cells is essential to gain insights in the communication process of these cells, to unravel the cause of brain disorders such as Alzheimer's or Parkinson's disease, or validate the effect of drugs on cardiac cells in the struggle against cardiac diseases, etc. IMEC's new micronail chip is the ideal instrument to study the communication mechanisms between cells. The electrodes in IMEC's micronail chip are downsized to the size of cells and even smaller. They consist of tiny nail structures made of a metal stem covered with an oxide layer, and a conductive (e.g. gold or titaniumnitride) tip. When cells are applied on the chip surface, their cell membrane strongly engulfs the nail structures, thereby realizing an intimate contact with the electrode. This very close contact improves the signal-to-interference ratio enabling precise recording of electrical signals and electrical stimulation of single cells.

"We tackled several challenges to realize this micronail chip such as keeping the cells alive on the chip surface; combining the wet cell solution with the electronics underneath without destroying the electronics; guiding the cell growth so that the cell body is just on top of one individual electrode; and last but not least: bring the cells as close as possible to the chip surface. Know, we have a unique instrument to record and interpret the signals of the neurons. We can also stimulate neurons and follow up the consequences to unravel the functioning of our brain," said Wolfgang Eberle, Group manager Bioelectronic systems.

Kris Verstreken, Director Bio-Nanoelectronics added, "Little is known about the functioning of our brain. Where do emotions origin? How do we build up memories? Or what is the cause of brain diseases such as Parkinson's disease or Alzheimer's disease? Many processes in our brain are unknown. Neurons are very plastic cells, continuously forming new connections and breaking up or rebuilding new ones. But how do they do that? And which are the consequences for learning and development? On the long term, we can use the knowledge that we build up with in vitro experiments on our micronail chip to diagnose diseases, or even develop therapies, by stimulating cells, or building new communication bridges between cells after a brain infarct."

IMEC is a registered trademark for the activities of IMEC International (a legal entity set up under Belgian law as a "stichting van openbaar nut"), IMEC in Belgium (IMEC vzw supported by the Flemish Government), stichting IMEC Nederland (IMEC-NL) and IMEC Taiwan Co. (IMEC-TW).

####

About IMEC
IMEC performs world-leading research in nanotechnology. IMEC leverages its scientific knowledge with the innovative power of its industrial partnerships in ICT, healthcare and energy. IMEC delivers industry-relevant technology solutions. In a unique high-tech environment, its international top talent is committed to providing the building blocks for a better life in a sustainable society.
IMEC is headquartered in Leuven, Belgium, and has offices in Belgium, the Netherlands, Taiwan, US, China and Japan. Its staff of more than 1,650 people include over 550 industrial residents and guest researchers. In 2008, IMEC's revenue (P&L) was 270 million euro.

For more information, please click here

Contacts:
Katrien Marent
Director of External Communications
Mobile: +32 474 30 28 66,

Barbara Kalkis
Maestro Marketing & PR
T: +1 408 996 9975

Copyright © IMEC

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Possible Futures

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Nanomedicine

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

The intermediates in a chemical reaction photographed 'red-handed' Researchers at the UPV/EHU-University of the Basque Country have for the first time succeeded in imaging all the steps in a complex organic reaction and have resolved the mechanisms that explain it May 4th, 2016

Nuclear pores captured on film: Using an ultra fast-scanning atomic force microscope, researchers from the University of Basel have filmed 'living' nuclear pore complexes at work for the first time May 3rd, 2016

Nanoelectronics

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

With simple process, UW-Madison engineers fabricate fastest flexible silicon transistor April 21st, 2016

All powered up: UCI chemists create battery technology with off-the-charts charging capacity April 21st, 2016

Announcements

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

Tools

Oxford Instruments Asylum Research and McGill University Announce the McGill AFM Summer School and Workshop, May 12-13, 2016 May 4th, 2016

The intermediates in a chemical reaction photographed 'red-handed' Researchers at the UPV/EHU-University of the Basque Country have for the first time succeeded in imaging all the steps in a complex organic reaction and have resolved the mechanisms that explain it May 4th, 2016

New tool allows scientists to visualize 'nanoscale' processes May 4th, 2016

FEI Launches Apreo Ė Industry-Leading Versatile, High-Performance SEM: The Apreo SEM provides high-resolution surface information with excellent contrast, and the flexibility to accommodate a large range of samples, applications and conditions May 4th, 2016

Nanobiotechnology

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

The intermediates in a chemical reaction photographed 'red-handed' Researchers at the UPV/EHU-University of the Basque Country have for the first time succeeded in imaging all the steps in a complex organic reaction and have resolved the mechanisms that explain it May 4th, 2016

Nuclear pores captured on film: Using an ultra fast-scanning atomic force microscope, researchers from the University of Basel have filmed 'living' nuclear pore complexes at work for the first time May 3rd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic