Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanotechnology treatment for burns reduces infection, inflammation

Abstract:
Oil-and-water-based nanoemulsion could be more effective than commonly used lotions

Nanotechnology treatment for burns reduces infection, inflammation

Ann Arbor, MI | Posted on September 15th, 2009

Treating second-degree burns with a nanoemulsion lotion sharply curbs bacterial growth and reduces inflammation that otherwise can jeopardize recovery, University of Michigan scientists have shown in initial laboratory studies.

U-M burn surgeon Mark R. Hemmila, M.D., reports today at the Interscience Conference for Antimicrobial Agents and Chemotherapy on results achieved with a nanoemulsion developed at U-M and licensed by U-M to Ann Arbor-based NanoBio Corporation.

The nanoemulsion shows promise in overcoming the limitations of current creams used in burn treatment, which aren't able to penetrate skin to kill sub-surface bacteria and don't have a strong effect on inflammation, says Hemmila, associate professor of surgery at the U-M Medical School.

In a collaborative effort between the U-M Department of Surgery and NanoBio Corporation, Hemmila led experiments at the U-M Medical School in which a nanoemulsion lotion was able to reduce bacterial growth one-thousand-fold compared to control animals receiving no treatment or a placebo. The nanoemulsion showed a similar reduction when compared to a topical antimicrobial agent commonly used in people with burns.

The nanoemulsion is made of soybean oil, alcohol, water and detergents emulsified into droplets less than 400 nanometers in diameter. It has proved effective at killing a variety of bacteria, fungi and viruses in previous research.

The scientists used the nanoemulsion to treat partial thickness burns, better known as second degree burns, over 20 percent of the body, to test its effectiveness in the type of injuries doctors commonly see in people brought to tertiary hospital trauma and burn centers. Such burn victims typically require aggressive treatment in intensive care both to rein in infection and to try to prevent vital fluids from leaking from blood vessels into the damaged skin, a dangerous situation caused in part by excessive inflammation within the body.

The nanoemulsion appears to reduce the action of two inflammatory agents or cytokines that play a role in cell signaling during this critical post-burn period. Slowing this action may prevent initial burn damage from becoming worse, and thus reduce the severity of the burn and extent of skin grafting needed, says Hemmila.

The findings add one more possible use to a growing list of promising applications for the patented nanoemulsion technology developed by James R. Baker Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences at U-M. Baker, a member of the research team, is the Ruth Dow Doan Professor of Nanotechnology and allergy division chief at the U-M Medical School. He is founder and CEO of NanoBio Corporation.

Uses for nanoemulsions include treatments for cold sores, now in phase 3 clinical trials, and for toenail fungus and cystic fibrosis infections, as well as vaccines against influenza and bioterrorism agents.

Before the burn treatment can be tested in people, further laboratory studies are needed to examine the nanoemulsion's effects on the overall healing process.

Patents/Disclosures: The patented nanoemulsion technology is licensed by U-M to NanoBio Corporation. Baker holds an equity interest in the company.

Others involved in the research: Stewart C. Wang, M.D., Ph.D., director of the U-M Burn Center and professor, U-M Department of Surgery; Aladdein Mattar, M.D., U-M Department of Surgery; Michael A. Taddonio, B.S., U-M Department of Surgery; Joyce A. Sutcliffe, Ph.D., NanoBio Corporation.

Funding: National Institutes of Health, American Association for the Surgery of Trauma, American College of Surgeons, and U-M Department of Surgery.

####

About University of Michigan
Excellence in medical education, patient care and research: That's what defines the University of Michigan Health System.

For more information, please click here

Contacts:
Media contact:
Anne Rueter

Phone: 734-764-2220

Copyright © University of Michigan

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Quantum networks: Back and forth are not equal distances! July 28th, 2015

Smart hydrogel coating creates 'stick-slip' control of capillary action July 27th, 2015

Industrial Nanotech, Inc. Provides Update on PCAOB Audited Financials July 27th, 2015

Global Corrosion Resistant Nano Coatings Market To 2015: Acute Market Reports July 27th, 2015

Possible Futures

Smaller, faster, cheaper: A new type of modulator for the future of data transmission July 27th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Global Corrosion Resistant Nano Coatings Market To 2015: Acute Market Reports July 27th, 2015

Global Zinc oxide nanopowders Industry 2015: Acute Market Reports July 25th, 2015

Nanomedicine

Stretching the limits on conducting wires July 25th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nanopaper as an optical sensing platform July 23rd, 2015

Albany College of Pharmacy and Health Sciences to Host One Week Symposium on Nanomedicine July 23rd, 2015

Announcements

Quantum networks: Back and forth are not equal distances! July 28th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Industrial Nanotech, Inc. Provides Update on PCAOB Audited Financials July 27th, 2015

Global Corrosion Resistant Nano Coatings Market To 2015: Acute Market Reports July 27th, 2015

Patents/IP/Tech Transfer/Licensing

Quantum networks: Back and forth are not equal distances! July 28th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Smarter window materials can control light and energy July 22nd, 2015

Magnetic nanoparticles could be key to effective immunotherapy: New method moves promising strategy closer to clinical use July 15th, 2015

Personal Care

Make mine a decaf: Breakthrough in knowledge of how nanoparticles grow: University of Leicester and CNRS researchers observe how nanoparticles grow when exposed to helium July 23rd, 2015

Environmentally friendly lignin nanoparticle 'greens' silver nanobullet to battle bacteria July 13th, 2015

Mesoporous Particles for the Development of Drug Delivery System Safe to Human Bodies June 9th, 2015

Nanoparticles in consumer products can significantly alter normal gut microbiome May 4th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project