Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Swansea researchers to study safety of nanoparticles

Optical microscopy image of nanoparticles (CdTe quantum dots) attached to the outer side of cell membranes. The image is taken 1 hour after introduction of the nanoparticles to the cellular environment. The attachment and subsequent internalisation of the nanoparticles is driven by a natural cellular process known as Endocytosis, this will deliver the particles into small internal vesicles (the endosomes) which are visible in the image as bright white spots within the cell.
Optical microscopy image of nanoparticles (CdTe quantum dots) attached to the outer side of cell membranes. The image is taken 1 hour after introduction of the nanoparticles to the cellular environment. The attachment and subsequent internalisation of the nanoparticles is driven by a natural cellular process known as Endocytosis, this will deliver the particles into small internal vesicles (the endosomes) which are visible in the image as bright white spots within the cell.

Abstract:
Researchers at Swansea University's Centre for NanoHealth have been awarded £1 million by the Research Councils' Nanoscience through Engineering to Application cross-council programme, led by the Engineering and Physical Science Research Council (EPSRC), to analyse the levels at which nanoparticles can be deemed safe within cells.

Swansea researchers to study safety of nanoparticles

Wales UK | Posted on September 2nd, 2009

The funding, awarded as part of a £1.4 million research grant to Swansea University and collaborators at the Institute of Materials Research at the University of Leeds (EPSRC), will enable Swansea University to develop techniques to accurately measure the nanoparticle dose delivered to biological cells, track the dose dilution as cells reproduce and provide vital information for researchers studying any potential toxic responses.

The four year project will also ensure closer collaboration between researchers at Swansea University's School of Engineering and School of Medicine, both of which have undertaken significant research into nanotechnology, nanometrology and nanotoxicology over the last 15 years.

Professor Huw Summers, lead researcher and Chair in Nanotechnology for Health at Swansea University said: "Current practice in the assessment of toxic dose uses bulk solution measures such as milliliters per gram to determine correct dosages rather than the fundamental measure of particle number. As the size of nanoparticles can vary significantly, some being as small as a protein molecule, determining optimal dosages for use in healthcare and beauty products such as sunscreens or cell-based diagnostics will be crucial.

"Our research which uses light emitting nanoparticles as optical markers within living cells that give an individual signal relating to cell generation will also provide vital information for our colleagues in nanotoxicology about how the dose evolves as cells divide and nanoparticles are passed onto future cell generations."

In recent years the application of nanotechnology to medicine has sparked the imagination of life scientists, engineers, clinicians and industry around the world.

These nanoscale technologies, for example, will enable researchers and scientists to apply engineering methodologies to successfully build and repair tissues such as cartilage and skin using advanced cell culture techniques, act as an early warning system for cancer or diabetes and make products like sunscreen or antiperspirants more effective.

Professor Summers explains: "We've been using nanoparticles for tracking lineage, proliferation and inheritance in populations of biological cells for a number of years. Using fluorescent nanocrystals known as quantum dots, we now have established protocols for introducing nanoparticles into cells and quantifying their interactions within the biological environment through optics-based experiments and detailed computational simulations.

"This enables us to not only predict and control the way cells and structures behave, but test these before they are introduced, reintroduced or implanted in the body to give better results in future healthcare applications."

The project research team will comprise 11 researchers, six academic investigators, three postdoctoral researchers and two PhD students.

In addition to optical tracking of nanoparticles in cells, measurement and computer simulation of the nanoparticle dose evolution, biological assessment of particle uptake and toxicology assays on skin, lung and immune system cells; Swansea University will also be working with the Institute of Materials Research at the University of Leeds which will be providing high resolution electron microscopy to image nanoparticles in cells and provide chemical analysis.

The project is closely linked to the Centre for NanoHealth initiative at Swansea University which stems from a number of joint research programmes between the School of Engineering and the School of Medicine and is expected to position Swansea University as the front-runner in nanotoxicology research in the UK.

The Centre for NanoHealth is the first state-of-the-art NanoHealth facility of its kind in Europe, bringing together the expertise of clinicians, life scientists, engineers and industry to develop cutting-edge technologies and devices for the benefit of patients everywhere.

The Centre for NanoHealth has been made possible after securing more than £10 million from the European Regional Development Fund through the Welsh Assembly Government.

####

About Swansea University
Founded in 1920, Swansea is a vibrant, research-led university at the forefront of academic and scientific discovery. Set in parkland overlooking Swansea Bay on the edge of the breathtaking Gower Peninsula, the University's location is captivating.

For more information, please click here

Contacts:
Press Office:
TEL: +44 (0) 1792 29 50 50
FAX: +44 (0)1792 29 50 48

Copyright © Swansea University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Preparing for Nano

Durnham University's DEEPEN project comes to a close September 26th, 2012

Technical Seminar at ANFoS 2012 August 22nd, 2012

Nanotechnology shows we can innovate without economic growth April 12th, 2012

Thailand to host NanoThailand 2012 December 18th, 2011

Govt.-Legislation/Regulation/Funding/Policy

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

'Electronic skin' could improve early breast cancer detection October 29th, 2014

Possible Futures

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

Nanocoatings Market By Product Is Expected To Reach USD 8.17 Billion By 2020: Grand View Research, Inc. October 15th, 2014

Perpetuus Carbon Group Receives Independent Verification of its Production Capacity for Graphenes at 140 Tonnes per Annum: Perpetuus Becomes the First Manufacturer in the Sector to Allow Third Party Audit October 7th, 2014

Nanomedicine

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Production of Biocompatible Polymers in Iran October 30th, 2014

Amorphous Coordination Polymer Particles as alternative to classical nanoplatforms for nanomedicine October 30th, 2014

'Electronic skin' could improve early breast cancer detection October 29th, 2014

Announcements

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Personal Care

Sunblock poses potential hazard to sea life August 20th, 2014

AQUANOVA receives Technology Leadership Award 2014 FROST & SULLIVAN honors NovaSOL® Technology again August 12th, 2014

Nanotechnology used in sunscreens: a Mexican achievement May 14th, 2014

Production of Nanocapsule from Sea-Buckthorn Extract in Iran May 3rd, 2014

Safety-Nanoparticles/Risk management

Nanosafety research – there’s room for improvement October 29th, 2014

Plastic nanoparticles also harm freshwater organisms October 18th, 2014

Human health, wealth require expanded marine science, experts say: In Rome, European experts publish a 'common vision' of priorities for marine research and action through 2020 October 9th, 2014

Coating Nanotubes with Aluminum Oxide Lowers Risk of Lung Injury October 6th, 2014

Quantum Dots/Rods

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

QD Vision Wins Prestigious Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency October 16th, 2014

Ultrafast remote switching of light emission October 2nd, 2014

Platinum meets its match in quantum dots from coal: Rice University's cheap hybrid outperforms rare metal as fuel-cell catalyst October 1st, 2014

Nanobiotechnology

Tiny carbon nanotube pores make big impact October 29th, 2014

Molecular beacons shine light on how cells 'crawl' October 27th, 2014

Breakthrough in molecular electronics paves the way for DNA-based computer circuits in the future: DNA-based programmable circuits could be more sophisticated, cheaper and simpler to make October 27th, 2014

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE